Extracellular vesicles from a natural source for tailor-made nanomaterials

Resultado final

Website and Logo

Ves4Us Logo and Website with intranet section

Optimal culture conditions

Optimised cultivation conditions are determined

Gender Action Plan

The Gender Action Plan will promote equality within the framework of the project

Quality Management system

A quality plan, compatible to UNI EN ISO 9001:2015 and OECD GLP standards, for the management of procedures

Dissemination and Communication Plan
Training plan

A training plan will describe detailed actions to improve the interdisciplinary methodology and the scientific cross-fertilisation amongst the partners by training staff and students of each participant institution for targeted collaborative experimentation

Cellular response to natural source-derived EVs

The cellular response to EVs will be in depth described

Functionalization strategy report

Description of the state of the art strategy/ies to be applied for micoalgal EV functionalization

First report on outreach activities

Report on outreach activities

Second report on outreach activities

Report on outreach activities

Characterization and purification of functionalized EVs

Microfluidic technology for the characterization and purification of engineered EVs

SOPs for microalgal EVs

SOPs for EVs isolation, storage and transport

Preclinical studies in rodents

The potential shorttermlongterm systemic toxicity and in vivo stability of microalgaederived EVs will be assessed in rodents

Characteristics of MiPs

MiPs will be characterised and then tested for selectively capturing EVs from the microalgae cultivation media

BubbleMumble game

The science app game BubbleMumble on microalgal EV

Data Management Plan

DMP will be based on the 7-point structure as described in the grant agreement

Publicaciones

Budding and Fission of Membrane Vesicles: A Mini Review

Autores: Samo Penič, Luka Mesarec, Miha Fošnarič, Lucyna Mrówczyńska, Henry Hägerstrand, Veronika Kralj-Iglič, Aleš Iglič
Publicado en: Frontiers in Physics, Edición 8, 2020, ISSN 2296-424X
Editor: Frontiers in Physics
DOI: 10.3389/fphy.2020.00342

Enrichment of plasma in platelets and extracellular vesicles by the counterflow to erythrocyte settling

Autores: Božič, Darja, Vozel, Domen, Hočevar, Matej, Jeran, Marko, Jan, Zala, Pajnič, Manca, Pađen, Ljubiša, Iglič, Aleš, Battelino, Saba, Kralj-Iglič, Veronika
Publicado en: Platelets, 2021, ISSN 0953-7104
Editor: Taylor & Francis
DOI: 10.1080/09537104.2021.1961716

Correlation between adhesion strength and phase behaviour in solid-supported lipid membranes

Autores: N. Bibissidis, K. Betlem, G. Cordoyiannis, F. Prista-von Bonhorst, J. Goole, J. Raval, M. Daniel, W. Góźdź, A. Iglič, P. Losada-Pérez
Publicado en: Journal of Molecular Liquids, Edición 320, 2020, Página(s) 114492, ISSN 0167-7322
Editor: Elsevier BV
DOI: 10.1016/j.molliq.2020.114492

Antibacterial Activity and Amphidinol Profiling of the Marine Dinoflagellate Amphidinium carterae (Subclade III)

Autores: Maria Elena Barone, Elliot Murphy, Rachel Parkes, Gerard T. A. Fleming, Floriana Campanile, Olivier P. Thomas, Nicolas Touzet
Publicado en: International Journal of Molecular Sciences, Edición 22/22, 2021, Página(s) 12196, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222212196

Isolation of extracellular vesicles from microalgae: towards the production of sustainable and natural nanocarriers of bioactive compounds

Autores: Sabrina Picciotto, Maria E. Barone, David Fierli, Anita Aranyos, Giorgia Adamo, Darja Božič, Daniele P. Romancino, Christopher Stanly, Rachel Parkes, Svenja Morsbach, Samuele Raccosta, Carolina Paganini, Antonella Cusimano, Vincenzo Martorana, Rosina Noto, Rita Carrotta, Fabio Librizzi, Umberto Capasso Palmiero, Pamela Santonicola, Ales Iglič, Meiyu Gai, Laura Corcuera, Annamaria Kisslinger, El
Publicado en: Biomaterials Science, Edición 9/8, 2021, Página(s) 2917-2930, ISSN 2047-4830
Editor: Royal Society of Chemistry
DOI: 10.1039/d0bm01696a

Autologous Platelet- and Extracellular Vesicle-Rich Plasma Is an Effective Treatment Modality for Chronic Postoperative Temporal Bone Cavity Inflammation: Randomized Controlled Clinical Trial

Autores: Domen Vozel, Darja Božič, Marko Jeran, Zala Jan,Manca Pajnič, Ljubiša Pađen,Nejc Steiner, Veronika Kralj-Iglič, and Saba Battelino
Publicado en: Front Bioeng Biotechnoly, 2021, ISSN 2296-4185
Editor: Frontiers Media S.A.
DOI: 10.3389/fbioe.2021.677541

A failure mode and effect analysis (FMEA)-based approach for risk assessment of scientific processes in non-regulated research laboratories

Autores: A. Mascia, A. M. Cirafici, A. Bongiovanni, G. Colotti, G. Lacerra, M. Di Carlo, F. A. Digilio, G. L. Liguori, A. Lanati, A. Kisslinger
Publicado en: Accreditation and Quality Assurance, 2020, ISSN 0949-1775
Editor: Springer Verlag
DOI: 10.1007/s00769-020-01441-9

Comparative Response of Marine Microalgae to H2O2-Induced Oxidative Stress

Autores: Maria Elena Barone, Rachel Parkes, Helen Herbert, Adam McDonnell, Thomas Conlon, Anita Aranyos, David Fierli, Gerard T. A. Fleming, Nicolas Touzet
Publicado en: Applied Biochemistry and Biotechnology, Edición 193/12, 2021, Página(s) 4052-4067, ISSN 0273-2289
Editor: Humana Press, Inc.
DOI: 10.1007/s12010-021-03690-x

Sialylation of host proteins as targetable risk factor for COVID‐19 susceptibility and spreading: A hypothesis

Autores: Antonella Bongiovanni, Antonella Cusimano, Ida Annunziata, Alessandra d’Azzo
Publicado en: FASEB BioAdvances, Edición 3/3, 2021, Página(s) 192-197, ISSN 2573-9832
Editor: PublishMed
DOI: 10.1096/fba.2020-00073

Light Scattering as an Easy Tool to Measure Vesicles Weight Concentration

Autores: Giulia Di Prima, Fabio Librizzi, Rita Carrotta
Publicado en: Membranes, Edición 10/9, 2020, Página(s) 222, ISSN 2077-0375
Editor: Molecular Diversity Preservation International
DOI: 10.3390/membranes10090222

Subcellular Localization of uc.8+ as a Prognostic Biomarker in Bladder Cancer Tissue

Autores: Sara Terreri, Sara Mancinelli, Matteo Ferro, Maria Concetta Vitale, Sisto Perdonà, Luigi Castaldo, Vincenzo Gigantino, Vincenzo Mercadante, Rossella De Cecio, Gabriella Aquino, Marco Montella, Claudia Angelini, Eugenio Del Prete, Marianna Aprile, Angelo Ciaramella, Giovanna L. Liguori, Valerio Costa, George A. Calin, Evelina La Civita, Daniela Terracciano, Ferdinando Febbraio, and Amelia Cimmino
Publicado en: Cancers, 2021, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13040681

Curvature Potential Unveiled Topological Defect Attractors

Autores: Mesarec, Luka, Iglič, Aleš, Kralj-Iglič, Veronika, Góźdź, Wojciech, Virga, Epifanio G., Kralj, Samo
Publicado en: Crystals, 2021, ISSN 2073-4352
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cryst11050539

Nanoalgosomes: Introducing extracellular vesicles produced by microalgae

Autores: Giorgia Adamo, David Fierli, Daniele P. Romancino, Sabrina Picciotto, Maria E. Barone, Anita Aranyos, Darja Božič, Svenja Morsbach, Samuele Raccosta, Christopher Stanly, Carolina Paganini, Meiyu Gai, Antonella Cusimano, Vincenzo Martorana, Rosina Noto, Rita Carrotta, Fabio Librizzi, Loredana Randazzo, Rachel Parkes, Umberto Capasso Palmiero, Estella Rao, Angela Paterna, Pamela Santonicola, Ales
Publicado en: Journal of Extracellular Vesicles, Edición 10/6, 2021, ISSN 2001-3078
Editor: ISEV
DOI: 10.1002/jev2.12081

The Transcription Regulator Patz1 Is Essential for Neural Stem Cell Maintenance and Proliferation

Autores: Sara Mancinelli, Michela Vitiello, Maria Donnini, Francesca Mantile, Giuseppe Palma, Antonio Luciano, Claudio Arra, Laura Cerchia, Giovanna Lucia Liguori and Monica Fedele
Publicado en: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Editor: Original Research
DOI: 10.3389/fcell.2021.657149

On the Role of Curved Membrane Nanodomains and Passive and Active Skeleton Forces in the Determination of Cell Shape and Membrane Budding

Autores: Luka Mesarec, Mitja Drab, Samo Penič, Veronika Kralj-Iglič, Aleš Iglič
Publicado en: International Journal of Molecular Sciences, Edición 22/5, 2021, Página(s) 2348, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052348

Concentration of extracellular vesicles isolated from blood relative to the clinical pathological status of dogs with mast cell tumours

Autores: Metka Šimundić, Tanja Švara, Roman Štukelj, Judita L Krek, Mitja Gombač, Veronika Kralj-Iglič, Nataša Tozon
Publicado en: MEDLINE, 2021, ISSN 1476-5829
Editor: Blackwell Publishing Inc.
DOI: 10.1111/vco.12489

Isolation of Extracellular Vesicles From Microalgae: A Renewable and Scalable Bioprocess

Autores: Angela Paterna, Estella Rao, Giorgia Adamo, Samuele Raccosta, Sabrina Picciotto, Daniele Romancino, Rosina Noto, Nicolas Touzet, Antonella Bongiovanni and Mauro Manno
Publicado en: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2022.836747

Species-specific responses in pigments and fatty acids of five freshwater chlorophytes exposed to varying cultivation conditions

Autores: Rachel Parkes, Maria Elena Barone, Anita Aranyos, David Fierli, Henry Koehler, Eoin Gillespie, Nicolas Touzet
Publicado en: Process Biochemistry, Edición 112, 2022, Página(s) 35-44, ISSN 1359-5113
Editor: Elsevier Applied Science
DOI: 10.1016/j.procbio.2021.11.018

Green kiwifruit extracts protect motor neurons from death in a spinal muscular atrophy model in Caenorhabditis elegans

Autores: Nadia Mazzarella, Ivana Giangrieco, Serena Visone, Pamela Santonicola, Jannis Achenbach, Giuseppina Zampi, Maurizio Tamburrini, Elia Di Schiavi, Maria Antonietta Ciardiello
Publicado en: Food Science & Nutrition, Edición 7/7, 2019, Página(s) 2327-2335, ISSN 2048-7177
Editor: Wiley
DOI: 10.1002/fsn3.1078

Viscosity of Plasma as a Key Factor in Assessment of Extracellular Vesicles by Light Scattering

Autores: Božič, Sitar, Junkar, Štukelj, Pajnič, Žagar, Kralj-Iglič, Kogej
Publicado en: Cells, Edición 8/9, 2019, Página(s) 1046, ISSN 2073-4409
Editor: Department of Chemistry and Biochemistry, University of Ljubljana
DOI: 10.3390/cells8091046

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Autores: Clotilde Théry, Kenneth W Witwer, Elena Aikawa, Maria Jose Alcaraz, Johnathon D Anderson, Ramaroson Andriantsitohaina, Anna Antoniou, Tanina Arab, Fabienne Archer, Georgia K Atkin-Smith, D Craig Ayre, Jean-Marie Bach, Daniel Bachurski, Hossein Baharvand, Leonora Balaj, Shawn Baldacchino, Natalie N Bauer, Amy A Baxter, Mary Bebawy, Carla Beckham, Apolonija Bedina Zavec, Abderrahim Benmoussa, Anna
Publicado en: Journal of Extracellular Vesicles, Edición 7/1, 2018, Página(s) 1535750, ISSN 2001-3078
Editor: UK Limited
DOI: 10.1080/20013078.2018.1535750

Scalable Production and Isolation of Extracellular Vesicles: Available Sources and Lessons from Current Industrial Bioprocesses

Autores: Carolina Paganini, Umberto Capasso Palmiero, Gabriella Pocsfalvi, Nicolas Touzet, Antonella Bongiovanni, Paolo Arosio
Publicado en: Biotechnology Journal, 2019, Página(s) 1800528, ISSN 1860-6768
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800528

Inception Mechanisms of Tunneling Nanotubes

Autores: Mitja Drab, David Stopar, Veronika Kralj-Iglič, Aleš Iglič
Publicado en: Cells, Edición 8/6, 2019, Página(s) 626, ISSN 2073-4409
Editor: Univerza v Ljubljani
DOI: 10.3390/cells8060626

Membrane Transporters in Citrus clementina Fruit Juice-Derived Nanovesicles

Autores: Christopher Stanly, Maneea Moubarak, Immacolata Fiume, Lilla Turiák, Gabriella Pocsfalvi
Publicado en: International Journal of Molecular Sciences, Edición 20/24, 2019, Página(s) 6205, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20246205

A bio-orthogonal functionalization strategy for site-specific coupling of antibodies on vesicle surfaces after self-assembly

Autores: Meiyu Gai, Johanna Simon, Ingo Lieberwirth, Volker Mailänder, Svenja Morsbach, Katharina Landfester
Publicado en: Polymer Chemistry, 2020, ISSN 1759-9954
Editor: Royal Society of Chemistry
DOI: 10.1039/c9py01136f

Vaccination with (1–11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice

Autores: Francesca Mantile, Angelo Capasso, Nadia Villacampa, Maria Donnini, Giovanna L. Liguori, Gabriela Constantin, Piergiuseppe De Berardinis, Michael T. Heneka, Antonella Prisco
Publicado en: Aging Clinical and Experimental Research, 2019, ISSN 1720-8319
Editor: Springer International Publishing
DOI: 10.1007/s40520-019-01414-0

Normal red blood cells’ shape stabilized by membrane’s in-plane ordering

Autores: L. Mesarec, W. Góźdź, A. Iglič, V. Kralj-Iglič, E. G. Virga, S. Kralj
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-56128-0

Role of PA2G4P4 pseudogene in bladder cancer tumorigenesis

Autores: Laura Pisapia, Sara Terreri, Pasquale Barba, Marianna Mastroianni, Maria Donnini, Vincenzo Mercadante, Alessandro Palmieri, Paolo Verze, Vincenzo Mirone, Vincenzo Altieri, Gianluigi Califano, Giovanna Lucia Liguori, Maria Strazzullo, Amelia Cimmino, Giovanna Del Pozzo
Publicado en: Biology, Edición 9/4, 2020, Página(s) 66, ISSN 2079-7737
Editor: Biology
DOI: 10.3390/biology9040066

Minimizing isotropic and deviatoric membrane energy – An unifying formation mechanism of different cellular membrane nanovesicle types

Autores: Veronika Kralj-Iglič, Gabriella Pocsfalvi, Luka Mesarec, Vid Šuštar, Henry Hägerstrand, Aleš Iglič
Publicado en: PLOS ONE, Edición 15/12, 2020, Página(s) e0244796, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0244796

Quality Management Tools on the Stage: Old but New Allies for Rigor and Standardization of Extracellular Vesicle Studies

Autores: Giovanna L. Liguori, Annamaria Kisslinger
Publicado en: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Editor: Original Research
DOI: 10.3389/fbioe.2022.826252

Design of Transfections (DoT): implementation of Design of Experiments for cell transfection fine-tuning.

Autores: Sara Mancinelli; Andrea Turcato; Annamaria Kisslinger; Antonella Bongiovanni; Valeria Zazzu; Antonella Lanati; Giovanna L. Liguori
Publicado en: Biotechnology and Bioengineering, Edición 1, 2021, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27918

Decrease in Cellular Nanovesicles Concentration in Blood of Athletes More Than 15 Hours After Marathon

Autores: Zala Jan, Mitja Drab, Damjana Drobne, Apolonija Bedina Zavec, Mojca Benčina, Barbara Drasler, Matej Hočevar, Judita Lea Krek, Ljubiša Pađen, Manca Pajnič, Neža Repar, Boštjan Šimunič, Roman Štukelj, Veronika Kralj-Iglič
Publicado en: International Journal of Nanomedicine, Edición Volume 16, 2021, Página(s) 443-456, ISSN 1178-2013
Editor: Laboratory of Clinical Biophysics
DOI: 10.2147/ijn.s282200

Mechanical and Electrical Interaction of Biological Membranes with Nanoparticles and Nanostructured Surfaces

Autores: Jeel Raval, Ekaterina Gongadze, Metka Benčina, ,Ita Junkar, Niharika Rawat, Luka Mesarec,Veronika Kralj-Iglič,Wojciech Góźdź and Aleš Iglič
Publicado en: Membranes, 2021, ISSN 2077-0375
Editor: Molecular Diversity Preservation International
DOI: 10.3390/membranes11070533

The effect of lipid phase on liposome stability upon exposure to the mechanical stress

Autores: Joanna Doskocz, Paulina Dałek, Aleksander Foryś, Barbara Trzebicka, Magdalena Przybyło, Luka Mesarec, Aleš Iglič, Marek Langner
Publicado en: Biochimica et Biophysica Acta (BBA) - Biomembranes, Edición 1862/9, 2020, Página(s) 183361, ISSN 0005-2736
Editor: Elsevier BV
DOI: 10.1016/j.bbamem.2020.183361

Rapid Characterization and Quantification of Extracellular Vesicles by Fluorescence‐Based Microfluidic Diffusion Sizing

Autores: Carolina Paganini, Britta Hettich, Marie R.G. Kopp, Adam Eördögh, Umberto Capasso Palmiero, Giorgia Adamo, Nicolas Touzet, Mauro Manno, Antonella Bongiovanni, Pablo Rivera‐Fuentes, Jean‐Christophe Leroux, Paolo Arosio
Publicado en: Advanced Healthcare Materials, 2021, Página(s) 2100021, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202100021

Derechos de propiedad intelectual

EXTRACELLULAR VESICLES FROM MICROALGAE

Número de solicitud/publicación: 20 20086622
Fecha: 2020-12-17
Solicitante(s): INSTITUTE OF TECHNOLOGY SLIGO - ITS

METHOD FOR TREATMENT OF TOOLS AND TOOLS USED FOR ISOLATION OF MICROVESICLES, NANOVESICLES OR EXSOMES

Número de solicitud/publicación: 20 15069420
Fecha: 2015-08-25

EXTRACELLULAR VESICLES FROM MICROALGAE

Número de solicitud/publicación: 20 20086622
Fecha: 2020-12-17

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Resultado final

Publicaciones

Derechos de propiedad intelectual

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