Extracellular vesicles from a natural source for tailor-made nanomaterials

Risultati finali

Website and Logo

Ves4Us Logo and Website with intranet section

Optimal culture conditions

Optimised cultivation conditions are determined

Gender Action Plan

The Gender Action Plan will promote equality within the framework of the project

Quality Management system

A quality plan, compatible to UNI EN ISO 9001:2015 and OECD GLP standards, for the management of procedures

Dissemination and Communication Plan
Training plan

A training plan will describe detailed actions to improve the interdisciplinary methodology and the scientific cross-fertilisation amongst the partners by training staff and students of each participant institution for targeted collaborative experimentation

Cellular response to natural source-derived EVs

The cellular response to EVs will be in depth described

Functionalization strategy report

Description of the state of the art strategy/ies to be applied for micoalgal EV functionalization

First report on outreach activities

Report on outreach activities

Second report on outreach activities

Report on outreach activities

Characterization and purification of functionalized EVs

Microfluidic technology for the characterization and purification of engineered EVs

SOPs for microalgal EVs

SOPs for EVs isolation, storage and transport

Preclinical studies in rodents

The potential shorttermlongterm systemic toxicity and in vivo stability of microalgaederived EVs will be assessed in rodents

Characteristics of MiPs

MiPs will be characterised and then tested for selectively capturing EVs from the microalgae cultivation media

BubbleMumble game

The science app game BubbleMumble on microalgal EV

Data Management Plan

DMP will be based on the 7-point structure as described in the grant agreement

Pubblicazioni

Budding and Fission of Membrane Vesicles: A Mini Review

Autori: Samo Penič, Luka Mesarec, Miha Fošnarič, Lucyna Mrówczyńska, Henry Hägerstrand, Veronika Kralj-Iglič, Aleš Iglič
Pubblicato in: Frontiers in Physics, Numero 8, 2020, ISSN 2296-424X
Editore: Frontiers in Physics
DOI: 10.3389/fphy.2020.00342

Enrichment of plasma in platelets and extracellular vesicles by the counterflow to erythrocyte settling

Autori: Božič, Darja, Vozel, Domen, Hočevar, Matej, Jeran, Marko, Jan, Zala, Pajnič, Manca, Pađen, Ljubiša, Iglič, Aleš, Battelino, Saba, Kralj-Iglič, Veronika
Pubblicato in: Platelets, 2021, ISSN 0953-7104
Editore: Taylor & Francis
DOI: 10.1080/09537104.2021.1961716

Correlation between adhesion strength and phase behaviour in solid-supported lipid membranes

Autori: N. Bibissidis, K. Betlem, G. Cordoyiannis, F. Prista-von Bonhorst, J. Goole, J. Raval, M. Daniel, W. Góźdź, A. Iglič, P. Losada-Pérez
Pubblicato in: Journal of Molecular Liquids, Numero 320, 2020, Pagina/e 114492, ISSN 0167-7322
Editore: Elsevier BV
DOI: 10.1016/j.molliq.2020.114492

Antibacterial Activity and Amphidinol Profiling of the Marine Dinoflagellate Amphidinium carterae (Subclade III)

Autori: Maria Elena Barone, Elliot Murphy, Rachel Parkes, Gerard T. A. Fleming, Floriana Campanile, Olivier P. Thomas, Nicolas Touzet
Pubblicato in: International Journal of Molecular Sciences, Numero 22/22, 2021, Pagina/e 12196, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222212196

Isolation of extracellular vesicles from microalgae: towards the production of sustainable and natural nanocarriers of bioactive compounds

Autori: Sabrina Picciotto, Maria E. Barone, David Fierli, Anita Aranyos, Giorgia Adamo, Darja Božič, Daniele P. Romancino, Christopher Stanly, Rachel Parkes, Svenja Morsbach, Samuele Raccosta, Carolina Paganini, Antonella Cusimano, Vincenzo Martorana, Rosina Noto, Rita Carrotta, Fabio Librizzi, Umberto Capasso Palmiero, Pamela Santonicola, Ales Iglič, Meiyu Gai, Laura Corcuera, Annamaria Kisslinger, El
Pubblicato in: Biomaterials Science, Numero 9/8, 2021, Pagina/e 2917-2930, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/d0bm01696a

Autologous Platelet- and Extracellular Vesicle-Rich Plasma Is an Effective Treatment Modality for Chronic Postoperative Temporal Bone Cavity Inflammation: Randomized Controlled Clinical Trial

Autori: Domen Vozel, Darja Božič, Marko Jeran, Zala Jan,Manca Pajnič, Ljubiša Pađen,Nejc Steiner, Veronika Kralj-Iglič, and Saba Battelino
Pubblicato in: Front Bioeng Biotechnoly, 2021, ISSN 2296-4185
Editore: Frontiers Media S.A.
DOI: 10.3389/fbioe.2021.677541

A failure mode and effect analysis (FMEA)-based approach for risk assessment of scientific processes in non-regulated research laboratories

Autori: A. Mascia, A. M. Cirafici, A. Bongiovanni, G. Colotti, G. Lacerra, M. Di Carlo, F. A. Digilio, G. L. Liguori, A. Lanati, A. Kisslinger
Pubblicato in: Accreditation and Quality Assurance, 2020, ISSN 0949-1775
Editore: Springer Verlag
DOI: 10.1007/s00769-020-01441-9

Comparative Response of Marine Microalgae to H2O2-Induced Oxidative Stress

Autori: Maria Elena Barone, Rachel Parkes, Helen Herbert, Adam McDonnell, Thomas Conlon, Anita Aranyos, David Fierli, Gerard T. A. Fleming, Nicolas Touzet
Pubblicato in: Applied Biochemistry and Biotechnology, Numero 193/12, 2021, Pagina/e 4052-4067, ISSN 0273-2289
Editore: Humana Press, Inc.
DOI: 10.1007/s12010-021-03690-x

Sialylation of host proteins as targetable risk factor for COVID‐19 susceptibility and spreading: A hypothesis

Autori: Antonella Bongiovanni, Antonella Cusimano, Ida Annunziata, Alessandra d’Azzo
Pubblicato in: FASEB BioAdvances, Numero 3/3, 2021, Pagina/e 192-197, ISSN 2573-9832
Editore: PublishMed
DOI: 10.1096/fba.2020-00073

Light Scattering as an Easy Tool to Measure Vesicles Weight Concentration

Autori: Giulia Di Prima, Fabio Librizzi, Rita Carrotta
Pubblicato in: Membranes, Numero 10/9, 2020, Pagina/e 222, ISSN 2077-0375
Editore: Molecular Diversity Preservation International
DOI: 10.3390/membranes10090222

Subcellular Localization of uc.8+ as a Prognostic Biomarker in Bladder Cancer Tissue

Autori: Sara Terreri, Sara Mancinelli, Matteo Ferro, Maria Concetta Vitale, Sisto Perdonà, Luigi Castaldo, Vincenzo Gigantino, Vincenzo Mercadante, Rossella De Cecio, Gabriella Aquino, Marco Montella, Claudia Angelini, Eugenio Del Prete, Marianna Aprile, Angelo Ciaramella, Giovanna L. Liguori, Valerio Costa, George A. Calin, Evelina La Civita, Daniela Terracciano, Ferdinando Febbraio, and Amelia Cimmino
Pubblicato in: Cancers, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13040681

Curvature Potential Unveiled Topological Defect Attractors

Autori: Mesarec, Luka, Iglič, Aleš, Kralj-Iglič, Veronika, Góźdź, Wojciech, Virga, Epifanio G., Kralj, Samo
Pubblicato in: Crystals, 2021, ISSN 2073-4352
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cryst11050539

Nanoalgosomes: Introducing extracellular vesicles produced by microalgae

Autori: Giorgia Adamo, David Fierli, Daniele P. Romancino, Sabrina Picciotto, Maria E. Barone, Anita Aranyos, Darja Božič, Svenja Morsbach, Samuele Raccosta, Christopher Stanly, Carolina Paganini, Meiyu Gai, Antonella Cusimano, Vincenzo Martorana, Rosina Noto, Rita Carrotta, Fabio Librizzi, Loredana Randazzo, Rachel Parkes, Umberto Capasso Palmiero, Estella Rao, Angela Paterna, Pamela Santonicola, Ales
Pubblicato in: Journal of Extracellular Vesicles, Numero 10/6, 2021, ISSN 2001-3078
Editore: ISEV
DOI: 10.1002/jev2.12081

The Transcription Regulator Patz1 Is Essential for Neural Stem Cell Maintenance and Proliferation

Autori: Sara Mancinelli, Michela Vitiello, Maria Donnini, Francesca Mantile, Giuseppe Palma, Antonio Luciano, Claudio Arra, Laura Cerchia, Giovanna Lucia Liguori and Monica Fedele
Pubblicato in: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Editore: Original Research
DOI: 10.3389/fcell.2021.657149

On the Role of Curved Membrane Nanodomains and Passive and Active Skeleton Forces in the Determination of Cell Shape and Membrane Budding

Autori: Luka Mesarec, Mitja Drab, Samo Penič, Veronika Kralj-Iglič, Aleš Iglič
Pubblicato in: International Journal of Molecular Sciences, Numero 22/5, 2021, Pagina/e 2348, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052348

Concentration of extracellular vesicles isolated from blood relative to the clinical pathological status of dogs with mast cell tumours

Autori: Metka Šimundić, Tanja Švara, Roman Štukelj, Judita L Krek, Mitja Gombač, Veronika Kralj-Iglič, Nataša Tozon
Pubblicato in: MEDLINE, 2021, ISSN 1476-5829
Editore: Blackwell Publishing Inc.
DOI: 10.1111/vco.12489

Isolation of Extracellular Vesicles From Microalgae: A Renewable and Scalable Bioprocess

Autori: Angela Paterna, Estella Rao, Giorgia Adamo, Samuele Raccosta, Sabrina Picciotto, Daniele Romancino, Rosina Noto, Nicolas Touzet, Antonella Bongiovanni and Mauro Manno
Pubblicato in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2022.836747

Species-specific responses in pigments and fatty acids of five freshwater chlorophytes exposed to varying cultivation conditions

Autori: Rachel Parkes, Maria Elena Barone, Anita Aranyos, David Fierli, Henry Koehler, Eoin Gillespie, Nicolas Touzet
Pubblicato in: Process Biochemistry, Numero 112, 2022, Pagina/e 35-44, ISSN 1359-5113
Editore: Elsevier Applied Science
DOI: 10.1016/j.procbio.2021.11.018

Green kiwifruit extracts protect motor neurons from death in a spinal muscular atrophy model in Caenorhabditis elegans

Autori: Nadia Mazzarella, Ivana Giangrieco, Serena Visone, Pamela Santonicola, Jannis Achenbach, Giuseppina Zampi, Maurizio Tamburrini, Elia Di Schiavi, Maria Antonietta Ciardiello
Pubblicato in: Food Science & Nutrition, Numero 7/7, 2019, Pagina/e 2327-2335, ISSN 2048-7177
Editore: Wiley
DOI: 10.1002/fsn3.1078

Viscosity of Plasma as a Key Factor in Assessment of Extracellular Vesicles by Light Scattering

Autori: Božič, Sitar, Junkar, Štukelj, Pajnič, Žagar, Kralj-Iglič, Kogej
Pubblicato in: Cells, Numero 8/9, 2019, Pagina/e 1046, ISSN 2073-4409
Editore: Department of Chemistry and Biochemistry, University of Ljubljana
DOI: 10.3390/cells8091046

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Autori: Clotilde Théry, Kenneth W Witwer, Elena Aikawa, Maria Jose Alcaraz, Johnathon D Anderson, Ramaroson Andriantsitohaina, Anna Antoniou, Tanina Arab, Fabienne Archer, Georgia K Atkin-Smith, D Craig Ayre, Jean-Marie Bach, Daniel Bachurski, Hossein Baharvand, Leonora Balaj, Shawn Baldacchino, Natalie N Bauer, Amy A Baxter, Mary Bebawy, Carla Beckham, Apolonija Bedina Zavec, Abderrahim Benmoussa, Anna
Pubblicato in: Journal of Extracellular Vesicles, Numero 7/1, 2018, Pagina/e 1535750, ISSN 2001-3078
Editore: UK Limited
DOI: 10.1080/20013078.2018.1535750

Scalable Production and Isolation of Extracellular Vesicles: Available Sources and Lessons from Current Industrial Bioprocesses

Autori: Carolina Paganini, Umberto Capasso Palmiero, Gabriella Pocsfalvi, Nicolas Touzet, Antonella Bongiovanni, Paolo Arosio
Pubblicato in: Biotechnology Journal, 2019, Pagina/e 1800528, ISSN 1860-6768
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800528

Inception Mechanisms of Tunneling Nanotubes

Autori: Mitja Drab, David Stopar, Veronika Kralj-Iglič, Aleš Iglič
Pubblicato in: Cells, Numero 8/6, 2019, Pagina/e 626, ISSN 2073-4409
Editore: Univerza v Ljubljani
DOI: 10.3390/cells8060626

Membrane Transporters in Citrus clementina Fruit Juice-Derived Nanovesicles

Autori: Christopher Stanly, Maneea Moubarak, Immacolata Fiume, Lilla Turiák, Gabriella Pocsfalvi
Pubblicato in: International Journal of Molecular Sciences, Numero 20/24, 2019, Pagina/e 6205, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20246205

A bio-orthogonal functionalization strategy for site-specific coupling of antibodies on vesicle surfaces after self-assembly

Autori: Meiyu Gai, Johanna Simon, Ingo Lieberwirth, Volker Mailänder, Svenja Morsbach, Katharina Landfester
Pubblicato in: Polymer Chemistry, 2020, ISSN 1759-9954
Editore: Royal Society of Chemistry
DOI: 10.1039/c9py01136f

Vaccination with (1–11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice

Autori: Francesca Mantile, Angelo Capasso, Nadia Villacampa, Maria Donnini, Giovanna L. Liguori, Gabriela Constantin, Piergiuseppe De Berardinis, Michael T. Heneka, Antonella Prisco
Pubblicato in: Aging Clinical and Experimental Research, 2019, ISSN 1720-8319
Editore: Springer International Publishing
DOI: 10.1007/s40520-019-01414-0

Normal red blood cells’ shape stabilized by membrane’s in-plane ordering

Autori: L. Mesarec, W. Góźdź, A. Iglič, V. Kralj-Iglič, E. G. Virga, S. Kralj
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-56128-0

Role of PA2G4P4 pseudogene in bladder cancer tumorigenesis

Autori: Laura Pisapia, Sara Terreri, Pasquale Barba, Marianna Mastroianni, Maria Donnini, Vincenzo Mercadante, Alessandro Palmieri, Paolo Verze, Vincenzo Mirone, Vincenzo Altieri, Gianluigi Califano, Giovanna Lucia Liguori, Maria Strazzullo, Amelia Cimmino, Giovanna Del Pozzo
Pubblicato in: Biology, Numero 9/4, 2020, Pagina/e 66, ISSN 2079-7737
Editore: Biology
DOI: 10.3390/biology9040066

Minimizing isotropic and deviatoric membrane energy – An unifying formation mechanism of different cellular membrane nanovesicle types

Autori: Veronika Kralj-Iglič, Gabriella Pocsfalvi, Luka Mesarec, Vid Šuštar, Henry Hägerstrand, Aleš Iglič
Pubblicato in: PLOS ONE, Numero 15/12, 2020, Pagina/e e0244796, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0244796

Quality Management Tools on the Stage: Old but New Allies for Rigor and Standardization of Extracellular Vesicle Studies

Autori: Giovanna L. Liguori, Annamaria Kisslinger
Pubblicato in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Editore: Original Research
DOI: 10.3389/fbioe.2022.826252

Design of Transfections (DoT): implementation of Design of Experiments for cell transfection fine-tuning.

Autori: Sara Mancinelli; Andrea Turcato; Annamaria Kisslinger; Antonella Bongiovanni; Valeria Zazzu; Antonella Lanati; Giovanna L. Liguori
Pubblicato in: Biotechnology and Bioengineering, Numero 1, 2021, ISSN 0006-3592
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27918

Decrease in Cellular Nanovesicles Concentration in Blood of Athletes More Than 15 Hours After Marathon

Autori: Zala Jan, Mitja Drab, Damjana Drobne, Apolonija Bedina Zavec, Mojca Benčina, Barbara Drasler, Matej Hočevar, Judita Lea Krek, Ljubiša Pađen, Manca Pajnič, Neža Repar, Boštjan Šimunič, Roman Štukelj, Veronika Kralj-Iglič
Pubblicato in: International Journal of Nanomedicine, Numero Volume 16, 2021, Pagina/e 443-456, ISSN 1178-2013
Editore: Laboratory of Clinical Biophysics
DOI: 10.2147/ijn.s282200

Mechanical and Electrical Interaction of Biological Membranes with Nanoparticles and Nanostructured Surfaces

Autori: Jeel Raval, Ekaterina Gongadze, Metka Benčina, ,Ita Junkar, Niharika Rawat, Luka Mesarec,Veronika Kralj-Iglič,Wojciech Góźdź and Aleš Iglič
Pubblicato in: Membranes, 2021, ISSN 2077-0375
Editore: Molecular Diversity Preservation International
DOI: 10.3390/membranes11070533

The effect of lipid phase on liposome stability upon exposure to the mechanical stress

Autori: Joanna Doskocz, Paulina Dałek, Aleksander Foryś, Barbara Trzebicka, Magdalena Przybyło, Luka Mesarec, Aleš Iglič, Marek Langner
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Numero 1862/9, 2020, Pagina/e 183361, ISSN 0005-2736
Editore: Elsevier BV
DOI: 10.1016/j.bbamem.2020.183361

Rapid Characterization and Quantification of Extracellular Vesicles by Fluorescence‐Based Microfluidic Diffusion Sizing

Autori: Carolina Paganini, Britta Hettich, Marie R.G. Kopp, Adam Eördögh, Umberto Capasso Palmiero, Giorgia Adamo, Nicolas Touzet, Mauro Manno, Antonella Bongiovanni, Pablo Rivera‐Fuentes, Jean‐Christophe Leroux, Paolo Arosio
Pubblicato in: Advanced Healthcare Materials, 2021, Pagina/e 2100021, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202100021

Diritti di proprietà intellettuale

EXTRACELLULAR VESICLES FROM MICROALGAE

Numero candidatura/pubblicazione: 20 20086622
Data: 2020-12-17
Candidato/i: INSTITUTE OF TECHNOLOGY SLIGO - ITS

METHOD FOR TREATMENT OF TOOLS AND TOOLS USED FOR ISOLATION OF MICROVESICLES, NANOVESICLES OR EXSOMES

Numero candidatura/pubblicazione: 20 15069420
Data: 2015-08-25

EXTRACELLULAR VESICLES FROM MICROALGAE

Numero candidatura/pubblicazione: 20 20086622
Data: 2020-12-17

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