Project description
Innovative imaging to detect cancer-prone regions in tissues and organs
Tumours of the gastrointestinal tract account for over 20% of new cancer cases and many are fatal. Prevention and early diagnosis are critical to clinical outcome, but the majority of cases remain asymptomatic until advanced stages, and biomarkers for early detection are not always available. Early cancer stages are accompanied by tissue changes that cannot be easily detected by current scanning technologies. It means that a whole tissue region can be prone to cancer or that a tissue segment larger than the tumour is affected. The EU-funded SENSITIVE project aims to develop imaging methodologies for the detection of tumour-prone regions and early detection or assessment of tumour margins during treatment.
Objective
Cancer is a major cause of death worldwide. Gastrointestinal (GI) tract tumors are among the most common and deadliest
ones. Despite progress in imaging and treatment, the social impact of these diseases is enormous. All parties in the health
sector agree that prevention and/or early diagnosis is the most effective means to deal with cancer. Currently, cancer is
identified most often when symptomatic or large enough to be visualized in body scans or when histological alterations are
already present. What is lacking is an imaging method that could detect tissue changes that facilitate or predict tumor
development at an early stage. These alterations, collectively referred to as “field cancerization” is an exciting field of study
in cancer biology with profound ramifications in clinical practice. Molecular mechanisms underlying field cancerization are
being studied and the advances in molecular biology facilitate these studies. Never in the past however, have these changes
been sensed/measured by an imaging modality at the organ level. We thus propose the development of a multimodal
microscopy platform that will allow sensing of Raman and scattering properties at the organ level, in order to identify
molecular and structural fingerprints of early stage disease in the GI tract. Successful implementation will allow the
development of an endoscope especially designed for this purpose that will be used to detect early stage cancer in humans.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences software
- medical and health sciences clinical medicine surgery
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine oncology
- natural sciences physical sciences optics spectroscopy
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.2.1. - FET Open
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
RIA - Research and Innovation action
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-FETOPEN-2016-2017
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
115 27 ATHINA
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.