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Early Detection of cancer onset based on sensing field cancerization at the organ level

Resultado final

Multiannual Dissemination Strategy

A Multiannual Dissemination Strategy targeting different audiences will be created.

Clinical validation on Lynch syndrome (a) and Barrett esophagus (b).

The endoscope developed in D63 will be used for ScatteringRaman endoscopy on healthy and diseased tissue in patinets with LS and esophageal cancer

Exploitation Report including Case study

An Exploitation Report listing the exploitation of the SENSITIVE results

Project Web presence (Website and Social Media)

A functional website with a private area and social media accounts will be created in-house by partners EXELIXIS

Data Management Plan

"A deliverable ""Data Management Plan"" has been scheduled for m6 because the consortium will take part in the Open Research Data Pilot."


Biomedical Applications of Tissue Clearing and Three-Dimensional Imaging in Health and Disease

Autores: Maria Victoria Gómez-Gaviro, Daniel Sanderson, Jorge Ripoll, Manuel Desco
Publicado en: iScience, Issue 23/8, 2020, Page(s) 101432, ISSN 2589-0042
Editor: online
DOI: 10.1016/j.isci.2020.101432

Standardization and implementation of fluorescence molecular endoscopy in the clinic

Autores: Andrea J. Sterkenburg, Wouter T. R. Hooghiemstra, Iris Schmidt, Vasilis Ntziachristos, Wouter B. Nagengast, Dimitris Gorpas
Publicado en: Journal of Biomedical Optics, Issue 10833668, 2022, ISSN 1083-3668
Editor: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.27.7.074704

TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection

Autores: Apostolos Klinakis, Theodoros Rampias
Publicado en: EBioMedicine, Issue 58, 2020, Page(s) 102905, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102905

Intraoperative imaging in pathology-assisted surgery

Autores: Floris J. Voskuil, Jasper Vonk, Bert van der Vegt, Schelto Kruijff, Vasilis Ntziachristos, Pieter J. van der Zaag, Max J. H. Witjes, Gooitzen M. van Dam
Publicado en: Nature Biomedical Engineering, 2021, ISSN 2157-846X
Editor: Springer Nature Group
DOI: 10.1038/s41551-021-00808-8

Generation of Non-Small Cell Lung Cancer Patient-Derived Xenografts to Study Intratumor Heterogeneity

Autores: Zoi Kanaki, Alexandra Voutsina, Athina Markou, Ioannis S. Pateras, Konstantinos Potaris, Margaritis Avgeris, Periklis Makrythanasis, Emmanouil I. Athanasiadis, Ioannis Vamvakaris, Eleni Patsea, Konstantinos Vachlas, Evi Lianidou, Vassilis Georgoulias, Athanasios Kotsakis, Apostolos Klinakis
Publicado en: Cancers, Issue 13/10, 2021, Page(s) 2446, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13102446

Notch controls urothelial integrity in the mouse bladder

Autores: Varvara Paraskevopoulou, Vangelis Bonis, Vasilis S. Dionellis, Nikolaos Paschalidis, Pelagia Melissa, Evangelia Chavdoula, Eleni Vasilaki, Ioannis S. Pateras, Apostolos Klinakis
Publicado en: JCI Insight, Issue 5/3, 2020, ISSN 2379-3708
Editor: online
DOI: 10.1172/jci.insight.133232

Applications of Light-Sheet Microscopy in Microdevices

Autores: Albert-Smet, Ignacio; Marcos-Vidal, Asier; Vaquero, Juan José; Desco, Manuel; Muñoz-Barrutia, Arrate; Ripoll, Jorge
Publicado en: Frontiers in Neuroanatomy, Issue 1, 2019, ISSN 1662-5129
Editor: Frontiers Research Foundation
DOI: 10.3389/fnana.2019.00001

Qualitative disorder measurements from backscattering spectra through an optical fiber

Autores: R. Fernández, A. Marcos-Vidal, S. Gallego, A. Beléndez, M. Desco, J. Ripoll
Publicado en: Biomedical Optics Express, Issue 11/10, 2020, Page(s) 6038, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/boe.396013

The effect of S427F mutation on RXRα activity depends on its dimeric partner

Autores: Ioannis Galdadas, Vangelis Bonis, Paraskevi Vgenopoulou, Panos Kakoulidis, Georgia Stergiou, Zoe Cournia, Apostolos Klinakis
Publicado en: Chemical Science, Issue 20416520, 2021, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d1sc04465f

Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography

Autores: Wuwei Ren, Jingjing Jiang, Aldo Di Costanzo Mata, Alexander Kalyanov, Jorge Ripoll, Scott Lindner, Edoardo Charbon, Chao Zhang, Markus Rudin, Martin Wolf
Publicado en: Optics Express, Issue 28/7, 2020, Page(s) 9860, ISSN 1094-4087
Editor: Optical Society of America
DOI: 10.1364/oe.385392

Validation of Novel Molecular Imaging Targets Identified by Functional Genomic mRNA Profiling to Detect Dysplasia in Barrett’s Esophagus

Autores: Xiaojuan Zhao; Ruben Y. Gabriëls; Wouter T. R. Hooghiemstra; Marjory Koller; Gert Jan Meersma; Manon Buist-Homan; Lydia Visser; Dominic J. Robinson; Anna Tenditnaya; Dimitris Gorpas; Vasilis Ntziachristos; Arend Karrenbeld; Gursah Kats-Ugurlu; Rudolf S. N. Fehrmann; Wouter B. Nagengast
Publicado en: Cancers, Issue 20726694, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14102462

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