Early Detection of cancer onset based on sensing field cancerization at the organ level

Informations projet

SENSITIVE

N° de convention de subvention: 801347

DOI 10.3030/801347

Projet clôturé

Date de signature de la CE 3 Mai 2018

Date de début 1 Novembre 2018

Date de fin 31 Octobre 2022

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total € 2 965 326,25

Contribution de l’UE € 2 965 326,25

Coordonné par

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece

Livrables

Documents, reports (3)

Multiannual Dissemination Strategy

A Multiannual Dissemination Strategy targeting different audiences will be created.

Clinical validation on Lynch syndrome (a) and Barrett esophagus (b).

The endoscope developed in D63 will be used for ScatteringRaman endoscopy on healthy and diseased tissue in patinets with LS and esophageal cancer

Exploitation Report including Case study

An Exploitation Report listing the exploitation of the SENSITIVE results

Websites, patent fillings, videos etc. (1)

Project Web presence (Website and Social Media)

A functional website with a private area and social media accounts will be created in-house by partners EXELIXIS

Open Research Data Pilot (1)

Data Management Plan

"A deliverable ""Data Management Plan"" has been scheduled for m6 because the consortium will take part in the Open Research Data Pilot."

Publications

Peer reviewed articles (10)

Biomedical Applications of Tissue Clearing and Three-Dimensional Imaging in Health and Disease

Auteurs: Maria Victoria Gómez-Gaviro, Daniel Sanderson, Jorge Ripoll, Manuel Desco
Publié dans: iScience, Numéro 23/8, 2020, Page(s) 101432, ISSN 2589-0042
Éditeur: online
DOI: 10.1016/j.isci.2020.101432

Standardization and implementation of fluorescence molecular endoscopy in the clinic

Auteurs: Andrea J. Sterkenburg, Wouter T. R. Hooghiemstra, Iris Schmidt, Vasilis Ntziachristos, Wouter B. Nagengast, Dimitris Gorpas
Publié dans: Journal of Biomedical Optics, Numéro 10833668, 2022, ISSN 1083-3668
Éditeur: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.27.7.074704

TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection

Auteurs: Apostolos Klinakis, Theodoros Rampias
Publié dans: EBioMedicine, Numéro 58, 2020, Page(s) 102905, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102905

Generation of Non-Small Cell Lung Cancer Patient-Derived Xenografts to Study Intratumor Heterogeneity

Auteurs: Zoi Kanaki, Alexandra Voutsina, Athina Markou, Ioannis S. Pateras, Konstantinos Potaris, Margaritis Avgeris, Periklis Makrythanasis, Emmanouil I. Athanasiadis, Ioannis Vamvakaris, Eleni Patsea, Konstantinos Vachlas, Evi Lianidou, Vassilis Georgoulias, Athanasios Kotsakis, Apostolos Klinakis
Publié dans: Cancers, Numéro 13/10, 2021, Page(s) 2446, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13102446

Notch controls urothelial integrity in the mouse bladder

Auteurs: Varvara Paraskevopoulou, Vangelis Bonis, Vasilis S. Dionellis, Nikolaos Paschalidis, Pelagia Melissa, Evangelia Chavdoula, Eleni Vasilaki, Ioannis S. Pateras, Apostolos Klinakis
Publié dans: JCI Insight, Numéro 5/3, 2020, ISSN 2379-3708
Éditeur: online
DOI: 10.1172/jci.insight.133232

Applications of Light-Sheet Microscopy in Microdevices

Auteurs: Albert-Smet, Ignacio; Marcos-Vidal, Asier; Vaquero, Juan José; Desco, Manuel; Muñoz-Barrutia, Arrate; Ripoll, Jorge
Publié dans: Frontiers in Neuroanatomy, Numéro 1, 2019, ISSN 1662-5129
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnana.2019.00001

Qualitative disorder measurements from backscattering spectra through an optical fiber

Auteurs: R. Fernández, A. Marcos-Vidal, S. Gallego, A. Beléndez, M. Desco, J. Ripoll
Publié dans: Biomedical Optics Express, Numéro 11/10, 2020, Page(s) 6038, ISSN 2156-7085
Éditeur: The Optical Society
DOI: 10.1364/boe.396013

The effect of S427F mutation on RXRα activity depends on its dimeric partner

Auteurs: Ioannis Galdadas, Vangelis Bonis, Paraskevi Vgenopoulou, Panos Kakoulidis, Georgia Stergiou, Zoe Cournia, Apostolos Klinakis
Publié dans: Chemical Science, Numéro 20416520, 2021, ISSN 2041-6520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1sc04465f

Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography

Auteurs: Wuwei Ren, Jingjing Jiang, Aldo Di Costanzo Mata, Alexander Kalyanov, Jorge Ripoll, Scott Lindner, Edoardo Charbon, Chao Zhang, Markus Rudin, Martin Wolf
Publié dans: Optics Express, Numéro 28/7, 2020, Page(s) 9860, ISSN 1094-4087
Éditeur: Optical Society of America
DOI: 10.1364/oe.385392

Validation of Novel Molecular Imaging Targets Identified by Functional Genomic mRNA Profiling to Detect Dysplasia in Barrett’s Esophagus

Auteurs: Xiaojuan Zhao; Ruben Y. Gabriëls; Wouter T. R. Hooghiemstra; Marjory Koller; Gert Jan Meersma; Manon Buist-Homan; Lydia Visser; Dominic J. Robinson; Anna Tenditnaya; Dimitris Gorpas; Vasilis Ntziachristos; Arend Karrenbeld; Gursah Kats-Ugurlu; Rudolf S. N. Fehrmann; Wouter B. Nagengast
Publié dans: Cancers, Numéro 20726694, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14102462