Computational design of novel functions in helical proteins by deviating from ideal geometries

Project Information

HelixMold

Grant agreement ID: 802217

DOI

10.3030/802217

Project closed

EC signature date 17 December 2018

Start date 1 April 2019

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 414,00

EU contribution

€ 1 499 414,00

Coordinated by

TECHNISCHE UNIVERSITAET GRAZ
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Accelerating Biocatalysis Discovery with Machine Learning: A Paradigm Shift in Enzyme Engineering, Discovery, and Design

Author(s): Braun Markus, Gruber Christian C, Krassnigg Andreas, Kummer Arkadij, Lutz Stefan, Oberdorfer Gustav, Siirola Elina, Snajdrova Radka
Published in: ACS Catalysis, Issue 13, 2023, Page(s) 14454-14469, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.3c03417

Affinity Maturated Transferrin Receptor Apical Domain Blocks Machupo Virus Glycoprotein Binding

Author(s): Dick J. Sjöström, Birgit Grill, Elena Ambrosetti, Anuthariq Alikkam Veetil, Camilla Mohlin, Ana I. Teixeira, Gustav Oberdofer, Sinisa Bjelic
Published in: Journal of Molecular Biology, Issue 15th October 2023, 2023, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2023.168262

Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes

Author(s): Horst Lechner, Gustav Oberdorfer
Published in: ChemBioChem, 2022, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100599

Computational backbone design enables soluble engineering of transferrin receptor apical domain

Author(s): Dick J. Sjöström, Sarah A. Berger, Gustav Oberdorfer, Sinisa Bjelic
Published in: Proteins: Structure, Function, and Bioinformatics, Issue 88/12, 2020, Page(s) 1569-1577, ISSN 0887-3585
Publisher: Wiley-Liss Inc
DOI: 10.1002/prot.25974

Enzyme Machinery for Bacterial Glucoside Metabolism through a Conserved Non‐hydrolytic Pathway

Author(s): Klara Kastner, Johannes Bitter, Martin Pfeiffer, Christoph Grininger, Gustav Oberdorfer, Tea Pavkov‐Keller, Hansjörg Weber, Bernd Nidetzky
Published in: Angewandte Chemie International Edition, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202410681

A local platform for user-friendly FAIR data management and reproducible analytics

Author(s): Florian Wieser, Sarah Stryeck, Konrad Lang, Christoph Hahn, Gerhard G. Thallinger, Julia Feichtinger, Philipp Hack, Manfred Stepponat, Nirav Merchant, Stefanie Lindstaedt, Gustav Oberdorfer
Published in: Journal of Biotechnology, Issue 341, 2021, Page(s) 43-50, ISSN 0168-1656
Publisher: Elsevier BV
DOI: 10.1016/j.jbiotec.2021.08.004

Engineering of Transmembrane Alkane Monooxygenases to Improve a Key Reaction Step in the Synthesis of Polymer Precursor Tulipalin A

Author(s): Andrea Nigl, Veronica Delsoglio, Lucija Sovic, Marina Grgić, Lenny Malihan‐Yap, Kamela Myrtollari, Jelena Spasic, Margit Winkler, Gustav Oberdorfer, Andreas Taden, Iva Anić, Robert Kourist
Published in: Angewandte Chemie International Edition, 2025, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202503464

<scp>ESM</scp>‐scan—A tool to guide amino acid substitutions

Author(s): Massimo G. Totaro, Uršula Vide, Regina Zausinger, Andreas Winkler, Gustav Oberdorfer
Published in: Protein Science, Issue 33, 2024, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.5221

Sterol interactions influence the function of Wsc sensors

Author(s): Lukas Bernauer, Paula Berzak, Leonie Lehmayer, Julia Messenlehne, Gustav Oberdorfer, Günther Zellnig, Heimo Wolinski, Christoph Augustin, Melanie Baeck, Anita Emmerstorfer-Augustin
Published in: Journal of Lipid Research, Issue 2nd November 2023, 2023, ISSN 0022-2275
Publisher: Lipid Research, Inc.
DOI: 10.1016/j.jlr.2023.100466

Other (2)

Computational design of a thermostable de novo biocatalyst for whole cell biotransformations

Author(s): Wael Elaily, David Stoll, Morakot Chakatok, Matteo Aleotti, Birgit Grill, Horst Lechner, Melanie Hall, Gustav Oberdorfer
Published in: bioRxiv, Issue bioRxiv 2024.10.07.617055, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.07.617055

Computational design of highly active de novo enzymes

Author(s): Markus Braun, Adrian Tripp, Morakot Chakatok, Sigrid Kaltenbrunner, Massimo G. Totaro, David Stoll, Aleksandar Bijelic, Wael Elaily, Shlomo Yakir Yakir Hoch, Matteo Aleotti, Melanie Hall, Gustav Oberdorfer
Published in: bioRxiv, Issue bioRxiv 2024.08.02.606416, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.08.02.606416