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Computational design of novel functions in helical proteins by deviating from ideal geometries

Project description

New computational approaches promise to revolutionise protein design

Protein engineering has made spectacular progress, allowing researchers to design proteins with novel properties and behaviours, and for new purposes. However, attempts at learning how to introduce functions into genetically encodable proteins designed from scratch (de novo design) have lagged behind. The EU-funded HelixMold project plans to develop new computational approaches to address this challenge. The project's activities will allow the functionalisation of de novo designed proteins with high thermostability, extraordinary resistance to harsh chemical environments and high tolerance to organic solvents. Overall, the project's advances aim to revolutionise how proteins are generated for use in biotechnology and biomedicine.

Call for proposal

ERC-2018-STG
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Host institution

TECHNISCHE UNIVERSITAET GRAZ
Address
Rechbauerstrasse 12
8010 Graz
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 499 414

Beneficiaries (1)

TECHNISCHE UNIVERSITAET GRAZ
Austria
EU contribution
€ 1 499 414
Address
Rechbauerstrasse 12
8010 Graz
Activity type
Higher or Secondary Education Establishments