Computational design of novel functions in helical proteins by deviating from ideal geometries

Project description

New computational approaches promise to revolutionise protein design

Protein engineering has made spectacular progress, allowing researchers to design proteins with novel properties and behaviours, and for new purposes. However, attempts at learning how to introduce functions into genetically encodable proteins designed from scratch (de novo design) have lagged behind. The EU-funded HelixMold project plans to develop new computational approaches to address this challenge. The project's activities will allow the functionalisation of de novo designed proteins with high thermostability, extraordinary resistance to harsh chemical environments and high tolerance to organic solvents. Overall, the project's advances aim to revolutionise how proteins are generated for use in biotechnology and biomedicine.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › mathematics › pure mathematics › geometry

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

Topic(s)

• ERC-2018-STG - ERC Starting Grant

Call for proposal

ERC-2018-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

TECHNISCHE UNIVERSITAET GRAZ

Address

Rechbauerstrasse 12
8010 Graz
Austria

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 499 414

Beneficiaries (1)

TECHNISCHE UNIVERSITAET GRAZ

Austria

EU contribution

€ 1 499 414

Address

Rechbauerstrasse 12
8010 Graz

Activity type

Higher or Secondary Education Establishments