Neural drivers of functional disconnectivity in brain disorders

Project Information

DisConn

Grant agreement ID: 802371

DOI

10.3030/802371

Project closed

EC signature date 8 November 2018

Start date 1 February 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 125,00

EU contribution

€ 1 498 125,00

Coordinated by

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex

Author(s): Federico Rocchi, Carola Canella, Shahryar Noei, Daniel Gutierrez-Barragan, Ludovico Coletta, Alberto Galbusera, Stefano Vassanelli, Massimo Pasqualetti, Giuliano Iurilli, Stefano Panzeri, Alessandro Gozzi
Published in: Nature Communications, Issue 13(1), 2022, Page(s) 1056, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2020.08.05.237958

Microglia complement signaling promotes neuronal elimination and normal brain functional connectivity

Author(s): Senthilkumar Deivasigamani, Mariya T Miteva, Silvia Natale, Daniel Gutierrez-Barragan, Bernadette Basilico, Silvia Di Angelantonio, Laetitia Weinhard, Dmitry Molotkov, Sukrita Deb, Constantin Pape, Giulia Bolasco, Alberto Galbusera, Hiroki Asari, Alessandro Gozzi, Davide Ragozzino, Cornelius T Gross
Published in: Cerebral Cortex, 2023, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhad313

Evidence for increased parallel information transmission in human brain networks compared to macaques and male mice

Author(s): Alessandra Griffa, Mathieu Mach, Julien Dedelley, Daniel Gutierrez-Barragan, Alessandro Gozzi, Gilles Allali, Joanes Grandjean, Dimitri Van De Ville, Enrico Amico
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43971-z

A consensus protocol for functional connectivity analysis in the rat brain

Author(s): Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barrière, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Célestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka
Published in: Nature Neuroscience, Issue 26, 2025, Page(s) 673-681, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-023-01286-8

Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization

Author(s): Francesca Mandino, Domenic H. Cerri, Clement M. Garin, Milou Straathof, Geralda A. F. van Tilborg, M. Mallar Chakravarty, Marc Dhenain, Rick M. Dijkhuizen, Alessandro Gozzi, Andreas Hess, Shella D. Keilholz, Jason P. Lerch, Yen-Yu Ian Shih, Joanes Grandjean
Published in: Frontiers in Neuroinformatics, Issue 13, 2020, ISSN 1662-5196
Publisher: Frontiers Research Foundation
DOI: 10.3389/fninf.2019.00078

Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism

Author(s): Bo-yong Park, Seok-Jun Hong, Sofie L. Valk, Casey Paquola, Oualid Benkarim, Richard A. I. Bethlehem, Adriana Di Martino, Michael P. Milham, Alessandro Gozzi, B. T. Thomas Yeo, Jonathan Smallwood, Boris C. Bernhardt
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21732-0

Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network

Author(s): Jennifer D.Whitesell, AdamLiska, Ludovico Coletta, Karla E.Hirokawa, Phillip Bohn, Ali Williford, Peter A. Groblewski, Nile Graddis, Leonard Kuan, Joseph E.Knox, Anh Ho, Wayne Wakeman, Philip R. Nicovich, Thuc Nghi Nguyen, Cindy TJ van Velthoven, Emma Garren, Olivia Fong, Maitham Naeemi, Alex M.Henry, Nick Dee, Kimberly A. Smith, Boaz Levi, David Feng, Lydia Ng, Bosiljka Tasic, Hongkui Zeng, Stefa
Published in: Neuron, Issue 109 (3), 2020, Page(s) 545-559, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.11.011

Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

Author(s): Stavros Trakoshis, Pablo Martínez-Cañada, Federico Rocchi, Carola Canella, Wonsang You, Bhismadev Chakrabarti, Amber NV Ruigrok, Edward T Bullmore, John Suckling, Marija Markicevic, Valerio Zerbi, Simon Baron-Cohen, Alessandro Gozzi, Meng-Chuan Lai, Stefano Panzeri, Michael V Lombardo
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.55684

Macroscale coupling between structural and effective connectivity in the mouse brain

Author(s): Danilo Benozzo, Giorgia Baron, Ludovico Coletta, Alessandro Chiuso, Alessandro Gozzi, Alessandra Bertoldo
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-51613-7

Evolutionarily conserved fMRI network dynamics in the mouse, macaque, and human brain

Author(s): Daniel Gutierrez-Barragan, Julian S. B. Ramirez, Stefano Panzeri, Ting Xu, Alessandro Gozzi
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52721-8

Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure

Author(s): Urte Neniskyte, Ugne Kuliesiute, Auguste Vadisiute, Kristina Jevdokimenko, Ludovico Coletta, Senthilkumar Deivasigamani, Daina Pamedytyte, Neringa Daugelaviciene, Daiva Dabkeviciene, Emerald Perlas, Aditya Bali, Bernadette Basilico, Alessandro Gozzi, Davide Ragozzino, Cornelius T Gross
Published in: The EMBO Journal, Issue 42, 2023, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2022111790

CDKL5 sculpts functional callosal connectivity to promote cognitive flexibility

Author(s): Patricia Nora Awad, Valerio Zerbi, Erin M. Johnson-Venkatesh, Francesca Damiani, Marco Pagani, Marija Markicevic, Sarah Nickles, Alessandro Gozzi, Hisashi Umemori, Michela Fagiolini
Published in: Molecular Psychiatry, Issue 29, 2024, Page(s) 1698-1709, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-01962-y

Sex-biasing influence of autism-associated <i>Ube3a</i> gene overdosage at connectomic, behavioral, and transcriptomic levels

Author(s): Caterina Montani, Luigi Balasco, Marco Pagani, Filomena Grazia Alvino, Noemi Barsotti, A. Elizabeth de Guzman, Alberto Galbusera, Alessia de Felice, Thomas K. Nickl-Jockschat, Sara Migliarini, Simona Casarosa, Pierre Lau, Lorenzo Mattioni, Massimo Pasqualetti, Giovanni Provenzano, Yuri Bozzi, Michael V. Lombardo, Alessandro Gozzi
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: Science Pubslishing
DOI: 10.1126/sciadv.adg1421

Network structure of the mouse brain connectome with voxel resolution

Author(s): Ludovico Coletta, Marco Pagani, Jennifer D. Whitesell, Julie A. Harris, Boris Bernhardt, Alessandro Gozzi
Published in: Science Advances, Issue 6/51, 2020, Page(s) eabb7187, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abb7187

Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes.

Author(s): Valerio Zerbi; Marco Pagani; Marija Markicevic; Michela Matteoli; Davide Pozzi; Michela Fagiolini; Yuri Bozzi; Alberto Galbusera; Maria Luisa Scattoni; Giovanni Provenzano; Abhishek Banerjee; Abhishek Banerjee; Fritjof Helmchen; M A Basson; J. Ellegood; Jason P. Lerch; Jason P. Lerch; Markus Rudin; Alessandro Gozzi; Nicole Wenderoth
Published in: Molecular Psychiatry, Issue 1, 2022, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-021-01245-4

Dysfunctional d-aspartate metabolism in BTBR mouse model of idiopathic autism

Author(s): Tommaso Nuzzo, Masae Sekine, Daniela Punzo, Mattia Miroballo, Masumi Katane, Yasuaki Saitoh, Alberto Galbusera, Massimo Pasqualetti, Francesco Errico, Alessandro Gozzi, Jean-Pierre Mothet, Hiroshi Homma, Alessandro Usiello
Published in: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Issue 1868/12, 2020, Page(s) 140531, ISSN 1570-9639
Publisher: Elsevier BV
DOI: 10.1016/j.bbapap.2020.140531

Somatosensory processing deficits and altered cortico-hippocampal connectivity in Shank3b-/- mice

Author(s): Luigi Balasco; Marco Pagani; Luca Pangrazzi; Evgenia Schlosman; Lorenzo Mattioni; Alberto Galbusera; Giovanni Provenzano; Alessandro Gozzi; Yuri Bozzi
Published in: Cerebral Cortex, Issue 1, 2022, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhab399

Infraslow State Fluctuations Govern Spontaneous fMRI Network Dynamics

Author(s): Daniel Gutierrez-Barragan, M. Albert Basson, Stefano Panzeri, Alessandro Gozzi
Published in: Current Biology, Issue 29/14, 2019, Page(s) 2295-2306.e5, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2019.06.017

Mapping and comparing fMRI connectivity networks across species

Author(s): Marco Pagani, Daniel Gutierrez‐Barragan, A. Elizabeth de Guzman, Ting Xu, Alessandro Gozzi
Published in: Communications Biology, Issue 6, 2023, ISSN 2399-3642
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-023-05629-w

mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity

Author(s): Pagani M, Barsotti N, Bertero A, Trakoshis S, Ulysse L, Locarno A, Miseviciute I, De Felice A, Canella C, Supekar K, Galbusera A, Menon V, Tonini R, Deco G, Lombardo MV, Pasqualetti M, Gozzi A
Published in: Nature Communications, Issue 12, 2021, Page(s) 6804, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26131-z

Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis

Author(s): Joanes Grandjean, Carola Canella, Cynthia Anckaerts, Gülebru Ayrancı, Salma Bougacha, Thomas Bienert, David Buehlmann, Ludovico Coletta, Daniel Gallino, Natalia Gass, Clément M. Garin, Nachiket Abhay Nadkarni, Neele S. Hübner, Meltem Karatas, Yuji Komaki, Silke Kreitz, Francesca Mandino, Anna E. Mechling, Chika Sato, Katja Sauer, Disha Shah, Sandra Strobelt, Norio Takata, Isabel Wank, Tong Wu,
Published in: NeuroImage, Issue 205, 2020, Page(s) 116278, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2019.116278

Unique spatiotemporal fMRI dynamics in the awake mouse brain

Author(s): Daniel Gutierrez-Barragan, Neha Atulkumar Singh, Filomena Alvino, Ludovico Coletta, Federico Rocchi, Elizabeth De Guzman, Alberto Galbusera, Stefano Panzeri, Mauro Uboldi, Alessandro Gozzi
Published in: Current Biology, Issue 32(3), 2022, Page(s) 631-644.e6, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.12.015