Integration and adaptation of impaired mitochondrial fitness in orchestrating T cell dysfunction in the tumor microenvironment

Project Information

MitoGuide

Grant agreement ID: 802773

DOI 10.3030/802773

Project closed

EC signature date 23 October 2018

Start date 1 February 2019

End date 31 January 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 990,00

EU contribution € 1 499 990,00

Coordinated by

UNIVERSITE DE LAUSANNE
Switzerland

Publications

Peer reviewed articles (7)

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Author(s): Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel P. Trefny, Roberta Zappasodi, Syed Raza Mohmood, Juan Fernández-García, Chin-Hsien Tsai, Isabell Schulze, Florence Picard, Etienne Meylan, Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D. Wolchok, Taha Merghoub, Camilla Jandus, Alfred Zippelius, Ping-Chih Ho
Published in: Nature Immunology, Issue 21/3, 2020, Page(s) 298-308, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-019-0589-5

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours

Author(s): Roberta Zappasodi, Inna Serganova, Ivan J. Cohen, Masatomo Maeda, Masahiro Shindo, Yasin Senbabaoglu, McLane J. Watson, Avigdor Leftin, Rachana Maniyar, Svena Verma, Matthew Lubin, Myat Ko, Mayuresh M. Mane, Hong Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, Ellen Ackerstaff, Jason A. Koutcher, Ping-Chih Ho, Greg M. Delgoffe, Ronald Blasberg, Jedd D. Wolchok, Taha Merghoub
Published in: Nature, Issue 591/7851, 2021, Page(s) 652-658, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03326-4

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

Author(s): Yi-Ru Yu, Hana Imrichova, Haiping Wang, Tung Chao, Zhengtao Xiao, Min Gao, Marcela Rincon-Restrepo, Fabien Franco, Raphael Genolet, Wan-Chen Cheng, Camilla Jandus, George Coukos, Yi-Fan Jiang, Jason W. Locasale, Alfred Zippelius, Pu-Ste Liu, Li Tang, Christoph Bock, Nicola Vannini, Ping-Chih Ho
Published in: Nature Immunology, Issue 21/12, 2020, Page(s) 1540-1551, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-0793-3

Metabolic programming in dendritic cells tailors immune responses and homeostasis

Author(s): Sofie Hedlund Møller, Limei Wang, Ping-Chih Ho
Published in: Cellular & Molecular Immunology, 2021, ISSN 1672-7681
Publisher: Nature Publishing Group
DOI: 10.1038/s41423-021-00753-1

Lactate modulation of immune responses in inflammatory versus tumour microenvironments

Author(s): Michelangelo Certo, Chin-Hsien Tsai, Valentina Pucino, Ping-Chih Ho, Claudio Mauro
Published in: Nature Reviews Immunology, Issue 21/3, 2021, Page(s) 151-161, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-020-0406-2

Metabolic adaptation orchestrates tissue context‐dependent behavior in regulatory T cells

Author(s): Haiping Wang, Chun‐Hao Lu, Ping‐Chih Ho
Published in: Immunological Reviews, Issue 295/1, 2020, Page(s) 126-139, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.12844

Macrophage-derived glutamine boosts satellite cells and muscle regeneration

Author(s): Min Shang, Federica Cappellesso, Ricardo Amorim, Jens Serneels, Federico Virga, Guy Eelen, Stefania Carobbio, Melvin Y. Rincon, Pierre Maechler, Katrien De Bock, Ping-Chih Ho, Marco Sandri, Bart Ghesquière, Peter Carmeliet, Mario Di Matteo, Emanuele Berardi, Massimiliano Mazzone
Published in: Nature, Issue 587/7835, 2020, Page(s) 626-631, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2857-9