Genetics help to advance knowledge of coronary artery disease
Scientists perform genome-wide association studies (GWAS) to identify which genes are involved in human disease and to predict the presence of disease. Over the past few years, GWAS have discovered hundreds of single nucleotide polymorphisms (SNPs) – the most common type of genetic variation amongst people – that are closely linked to coronary artery disease (CAD). However, these SNPs normally describe only a few heritable traits. To better understand disease mechanisms, the EU-funded EnDeCAD project will explore the role of each CAD locus at the molecular level. The knowledge gained should improve risk prediction, biomarker identification and treatment selection in delivering healthcare.
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