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Enhancers Decoding the Mechanisms Underlying CAD Risk

Publications

Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells

Author(s): Redouane Aherrahrou, Liang Guo, V. Peter Nagraj, Aaron Aguhob, Jameson Hinkle, Lisa Chen, Joon Yuhl Soh, Dillon Lue, Gabriel F. Alencar, Arjan Boltjes, Sander W. van der Laan, Emily Farber, Daniela Fuller, Rita Anane-Wae, Ngozi Akingbesote, Ani W. Manichaikul, Lijiang Ma, Minna U. Kaikkonen, Johan L.M. Björkegren, Suna Önengüt-Gümüşcü, Gerard Pasterkamp, Clint L. Miller, Gary K. Owens, Alok
Published in: Circulation Research, Issue 127/12, 2020, Page(s) 1552-1565, ISSN 0009-7330
DOI: 10.1161/circresaha.120.317415

Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models

Author(s): Austin C. Conklin, Hitoo Nishi, Florencia Schlamp, Tiit Örd, Kadri Õunap, Minna U. Kaikkonen, Edward A. Fisher, Casey E. Romanoski
Published in: Immunometabolism, 2021, ISSN 2633-0407
DOI: 10.20900/immunometab20210022

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Author(s): Tiit Örd, Kadri Õunap, Lindsey K. Stolze, Redouane Aherrahrou, Valtteri Nurminen, Anu Toropainen, Ilakya Selvarajan, Tapio Lönnberg, Einari Aavik, Seppo Ylä-Herttuala, Mete Civelek, Casey E. Romanoski, Minna U. Kaikkonen
Published in: Circulation Research, Issue 129/2, 2021, Page(s) 240-258, ISSN 0009-7330
DOI: 10.1161/circresaha.121.318971

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Author(s): Marie A.C. Depuydt, Koen H.M. Prange, Lotte Slenders, Tiit Örd, Danny Elbersen, Arjan Boltjes, Saskia C.A. de Jager, Folkert W. Asselbergs, Gert J. de Borst, Einari Aavik, Tapio Lönnberg, Esther Lutgens, Christopher K. Glass, Hester M. den Ruijter, Minna U. Kaikkonen, Ilze Bot, Bram Slütter, Sander W. van der Laan, Seppo Yla-Herttuala, Michal Mokry, Johan Kuiper, Menno P.J. de Winther, Gerard P
Published in: Circulation Research, Issue 127/11, 2020, Page(s) 1437-1455, ISSN 0009-7330
DOI: 10.1161/circresaha.120.316770

The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages

Author(s): Huang, Zhiqiang; Liang, Ning; Goñi, Saioa; Damdimopoulos, Anastasios; Wang, Cheng; Ballaire, Raphaelle; Jager, Jennifer; Niskanen, Henri; Han, HongYa; Jakobsson, Tomas; Bracken, Adrian,; Aouadi, Myriam; Venteclef, Nicolas; Kaikkonen, Minna,; Fan, Rongrong; Treuter, Eckardt
Published in: Molecular Cell, Issue 81/5, 2021, ISSN 1097-2765
DOI: 10.1016/j.molcel.2020.12.040

Profiling of Primary and Mature miRNA Expression in Atherosclerosis-Associated Cell Types

Author(s): Pierre R. Moreau, Vanesa Tomas Bosch, Maria Bouvy-Liivrand, Kadri Õunap, Tiit Örd, Heidi H. Pulkkinen, Petri Pölönen, Merja Heinäniemi, Seppo Ylä-Herttuala, Johanna P. Laakkonen, Suvi Linna-Kuosmanen, Minna U. Kaikkonen
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 41/7, 2021, Page(s) 2149-2167, ISSN 1079-5642
DOI: 10.1161/atvbaha.121.315579

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Author(s): Ilakya Selvarajan, Anu Toropainen, Kristina M. Garske, Maykel López Rodríguez, Arthur Ko, Zong Miao, Dorota Kaminska, Kadri Õunap, Tiit Örd, Aarthi Ravindran, Oscar H. Liu, Pierre R. Moreau, Ashik Jawahar Deen, Ville Männistö, Calvin Pan, Anna-Liisa Levonen, Aldons J. Lusis, Sami Heikkinen, Casey E. Romanoski, Jussi Pihlajamäki, Päivi Pajukanta, Minna U. Kaikkonen
Published in: The American Journal of Human Genetics, Issue 108/3, 2021, Page(s) 411-430, ISSN 0002-9297
DOI: 10.1016/j.ajhg.2021.02.006

Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis

Author(s): Isidore Mushimiyimana, Henri Niskanen, Mustafa Beter, Johanna P Laakkonen, Minna U Kaikkonen, Seppo Ylä-Herttuala, Nihay Laham-Karam
Published in: Nucleic Acids Research, 2021, ISSN 0305-1048
DOI: 10.1093/nar/gkab633

NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli

Author(s): Suvi Linna-Kuosmanen, Vanesa Tomas Bosch, Pierre R Moreau, Maria Bouvy-Liivrand, Henri Niskanen, Emilia Kansanen, Annukka Kivelä, Juha Hartikainen, Mikko Hippeläinen, Hannu Kokki, Pasi Tavi, Anna-Liisa Levonen, Minna U Kaikkonen
Published in: Cardiovascular Research, Issue Jul 19, 2020, ISSN 0008-6363
DOI: 10.1093/cvr/cvaa219

Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation‐Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl‐Coenzyme A Desaturase As an Enhancer RNA

Author(s): Jihane N. Benhammou, Arthur Ko, Marcus Alvarez, Minna U. Kaikkonen, Carl Rankin, Kristina M. Garske, David Padua, Yash Bhagat, Dorota Kaminska, Vesa Kärjä, Jussi Pihlajamäki, Joseph R. Pisegna, Päivi Pajukanta
Published in: Hepatology Communications, Issue 3/10, 2019, Page(s) 1356-1372, ISSN 2471-254X
DOI: 10.1002/hep4.1413

Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits

Author(s): Lindsey K. Stolze, Austin C. Conklin, Michael B. Whalen, Maykel López Rodríguez, Kadri Õunap, Ilakya Selvarajan, Anu Toropainen, Tiit Örd, Jin Li, Anna Eshghi, Alice E. Solomon, Yun Fang, Minna U. Kaikkonen, Casey E. Romanoski
Published in: The American Journal of Human Genetics, Issue 106/6, 2020, Page(s) 748-763, ISSN 0002-9297
DOI: 10.1016/j.ajhg.2020.04.008

Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation

Author(s): Leena E. Viiri, Tommi Rantapero, Mostafa Kiamehr, Anna Alexanova, Mikko Oittinen, Keijo Viiri, Henri Niskanen, Matti Nykter, Minna U. Kaikkonen, Katriina Aalto-Setälä
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-39215-0

Genomic Landscapes of Noncoding RNAs Regulating VEGFA and VEGFC Expression in Endothelial Cells

Author(s): Isidore Mushimiyimana, Vanesa Tomas Bosch, Henri Niskanen, Nicholas L. Downes, Pierre R. Moreau, Kiley Hartigan, Seppo Ylä-Herttuala, Nihay Laham-Karam, Minna U. Kaikkonen
Published in: Molecular and Cellular Biology, Issue 41/7, 2021, ISSN 0270-7306
DOI: 10.1128/mcb.00594-20