Functional Diversity of T cells

Project Information

FunDiT

Grant agreement ID: 802878

DOI 10.3030/802878

Project closed

EC signature date 10 October 2018

Start date 1 January 2019

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 725 000,00

EU contribution € 1 725 000,00

Coordinated by

USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE
Czechia

Publications

Peer reviewed articles (7)

IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy

Author(s): Veronika Niederlova, Oksana Tsyklauri, Marek Kovar, Ondrej Stepanek
Published in: Trends in Immunology, 2023, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2023.09.003

Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells

Author(s): Veronika Horkova, Ales Drobek, Darina Paprckova, Veronika Niederlova, Avishek Prasai, Valeria Uleri, Daniela Glatzova, Markus Kraller, Michaela Cesnekova, Sarka Janusova, Eva Salyova, Oksana Tsyklauri, Theresa A. Kadlecek, Katerina Krizova, René Platzer, Kilian Schober, Dirk H. Busch, Arthur Weiss, Johannes B. Huppa, Ondrej Stepanek
Published in: Nature Immunology, Issue 24, 2023, Page(s) 174–185, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-022-01366-0

Phenotypic and Clonal Stability of Antigen-Inexperienced Memory-like T Cells across the Genetic Background, Hygienic Status, and Aging

Author(s): Alena Moudra, Veronika Niederlova, Jiri Novotny, Lucie Schmiedova, Jan Kubovciak, Tereza Matejkova, Ales Drobek, Michaela Pribikova, Romana Stopkova, Dagmar Cizkova, Ales Neuwirth, Juraj Michalik, Katerina Krizova, Tomas Hudcovic, Michal Kolar, Hana Kozakova, Jakub Kreisinger, Pavel Stopka, Ondrej Stepanek
Published in: The Journal of Immunology, Issue 206/9, 2021, Page(s) 2109-2121, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2001028

Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2

Author(s): Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Published in: eLife, Issue 12, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.79342

Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

Author(s): Veronika Horkova, Ales Drobek, Daniel Mueller, Celine Gubser, Veronika Niederlova, Lena Wyss, Carolyn G. King, Dietmar Zehn, Ondrej Stepanek
Published in: Cell Reports, Issue 30/5, 2020, Page(s) 1504-1514.e7, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.01.008

Systematic analysis of the IL ‐17 receptor signalosome reveals a robust regulatory feedback loop

Author(s): Helena Draberova, Sarka Janusova, Daniela Knizkova, Tereza Semberova, Michaela Pribikova, Andrea Ujevic, Karel Harant, Sofija Knapkova, Matous Hrdinka, Viola Fanfani, Giovanni Stracquadanio, Ales Drobek, Klara Ruppova, Ondrej Stepanek, Peter Draber
Published in: The EMBO Journal, 2020, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2019104202

CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology

Author(s): Daniela Knizkova, Michaela Pribikova, Helena Draberova, Tereza Semberova, Tijana Trivic, Alzbeta Synackova, Andrea Ujevic, Jana Stefanovic, Ales Drobek, Martina Huranova, Veronika Niederlova, Oksana Tsyklauri, Ales Neuwirth, Jolana Tureckova, Ondrej Stepanek,Peter Draber
Published in: Nature Immunology, Issue 23, 2022, Page(s) 1644–1652, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-022-01325-9

Other (1)

ABIN1 is a negative regulator of effector functions in cytotoxic T cells

Author(s): Sarka Janusova, Darina Paprckova, Juraj Michalik, Valeria Uleri, Ales Drobek, Eva Salyova, Louise Chorfi, Ales Neuwirth, Jan Prochazka, Radislav Sedlacek, Peter Draber, Ondrej Stepanek
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.10.25.563918