Mechanism and functional impact of ultra-long 3’ UTRs in the Drosophila nervous system

Project Information

Neuro-UTR

Grant agreement ID: 803258

DOI 10.3030/803258

EC signature date 30 October 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 497 500,00

EU contribution € 1 497 500,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Publications

Peer reviewed articles (6)

Regulation of neuronal RNA signatures by ELAV/Hu proteins

Author(s): Valérie Hilgers
Published in: Wiley interdisciplinary reviews : WIREs RNA, Issue 1, 2022, ISSN 1757-7004
Publisher: John Wiley and Sons Inc.
DOI: 10.1002/wrna.1733

The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

Author(s): Grzejda, D. Mach, J. Schweizer, J. A. Hummel, B. Rezansoff, A. M. Eggenhofer, F. Panhale, A. Lalioti, M. E. Cabezas Wallscheid, N. Backofen, R. Felsenberg, J. Hilgers, V.
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abo5578

Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference

Author(s): Javier J. Castro Alvarez; Maxime Revel; Judit Carrasco; Fabienne Cléard; Daniel Pauli; Valérie Hilgers; François Karch; Robert K. Maeda
Published in: PLoS Genetics, Issue 1, 2021, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1009843

A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation

Author(s): Judit Carrasco; Fernando Mateos; Valérie Hilgers
Published in: Cell Reports, Issue 1, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111542

Sites of transcription initiation drive mRNA isoform selection

Author(s): Alfonso-Gonzalez, Carlos; Legnini, Ivano; Holec, Sarah; Arrigoni, Laura; Ozbulut, Hasan Can; Mateos, Fernando; Koppstein, David; Rybak-Wolf, Agnieszka; Bönisch, Ulrike; Rajewsky, Nikolaus; Hilgers, Valérie
Published in: Cell, 2023, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2023.04.012

ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue

Author(s): Judit Carrasco, Michael Rauer, Barbara Hummel, Dominika Grzejda, Carlos Alfonso-Gonzalez, Yeon Lee, Qingqing Wang, Monika Puchalska, Gerhard Mittler, Valérie Hilgers
Published in: Molecular Cell, 2020, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.09.011