Role of ultra-long 3’ UTRs in neuronal functions
The recently discovered striking process of drastic lengthening of the 3’ untranslated region (3’ UTR) of hundreds of genes occurs in neurons. The function of the resulting ultra-long 3’ UTRs is unknown. It is essential to study regulatory processes and define the function of these novel 3’ UTRs, to better understand the role of RNA deregulation in neurological diseases. The EU-funded Neuro-UTR project investigates regulation and function of ultra-long 3’ UTRs in the Drosophila nervous system. Research is based on the hypothesis that mRNAs carrying ultra-long 3’ UTRs enable critical communication between transcription regulation and synaptic function. Neuro-UTR will define the mechanism of the co-transcriptional processes that give rise to ultra-long 3’ UTRs. The project will analyse the role of ultra-long 3’ UTRs in memory, ageing and disease.
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