Cellular modulation by the mitochondrial unfolded protein response

Project Information

mitoUPR

Grant agreement ID: 803565

DOI

10.3030/803565

Project closed

EC signature date 26 October 2018

Start date 1 February 2019

End date 31 July 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 437 500,00

EU contribution

€ 1 437 500,00

Coordinated by

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

A cytosolic surveillance mechanism activates the mitochondrial UPR

Author(s): F. X. Reymond Sutandy, Ines Gößner, Georg Tascher & Christian Münch
Published in: Nature, Issue 618, 2023, Page(s) 849–854, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1038/s41586-023-06142-0

Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells

Author(s): Aneesha Kohli, Lucie Sauerhering, Sarah K Fehling, Kevin Klann, Helmut Geiger, Stephan Becker, Benjamin Koch, Patrick C Baer, Thomas Strecker, Christian Münch
Published in: Life Science Alliance, 2022, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.202201371

Monitoring Mitochondrial Protein Import Using Mitochondrial Targeting Sequence (MTS)-eGFP

Author(s): Jonas B. Michaelis, Süleyman Bozkurt, Jasmin A. Schäfer, Christian Münch
Published in: bio-protocol, Issue Vol12, Issue 24, 2022, ISSN 2331-8325
Publisher: bio-protocols Journal
DOI: 10.21769/bioprotoc.4578

CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2

Author(s): Key, Jana; Gispert, Suzana; Koornneef, Lieke; Sleddens-Linkels, Esther; Kohli, Aneesha; Torres-Odio, Sylvia; Koepf, Gabriele; Amr, Shady; Reichlmeir, Marina; Harter, Patrick N.; West, Andrew Phillip; Münch, Christian; Baarends, Willy M.; Auburger, Georg; Gribnau, Joost
Published in: Cells, 12(1):52. Multidisciplinary Digital Publishing Institute (MDPI), Issue 5, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12010052

Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication

Author(s): Kevin Klann, Denisa Bojkova, Georg Tascher, Sandra Ciesek, Christian Münch, Jindrich Cinatl
Published in: Molecular Cell, Issue 80/1, 2020, Page(s) 164-174.e4, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.08.006

Unbiased translation proteomics upon cell stress

Author(s): Kevin Klann, Christian Münch
Published in: Molecular & Cellular Oncology, Issue 7/4, 2020, Page(s) 1763150, ISSN 2372-3556
Publisher: Taylor & Francis Online
DOI: 10.1080/23723556.2020.1763150

SARS-CoV-2 Variants Show Different Host Cell Proteome Profiles With Delayed Immune Response Activation in Omicron-Infected Cells

Author(s): Melinda Metzler, Rebecca George Tharyan, Kevin Klann, Katharina Grikscheit, Denisa Bojkova, Jindrich Cinatl, Georg Tascher, Sandra Ciesek, Christian Münch
Published in: Molecular & Cellular Proteomics, Issue Vol22 Issue 5, 2023, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2023.100537

Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements

Author(s): Kevin Klann, Christian Münch
Published in: Analytical Chemistry, Issue 92/12, 2020, Page(s) 8041-8045, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c01749

Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α

Author(s): Kevin Klann, Georg Tascher, Christian Münch
Published in: Molecular Cell, Issue 77/4, 2020, Page(s) 913-925.e4, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.11.010

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

Author(s): Denisa Bojkova, Kevin Klann, Benjamin Koch, Marek Widera, David Krause, Sandra Ciesek, Jindrich Cinatl, Christian Münch
Published in: Nature, Issue 583/7816, 2020, Page(s) 469-472, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2332-7

Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery

Author(s): Jasmin Adriana Schäfer, Süleyman Bozkurt, Jonas B. Michaelis, Kevin Klann, Christian Münch
Published in: Molecular Cell, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.11.004

PBLMM: Peptide‐based linear mixed models for differential expression analysis of shotgun proteomics data

Author(s): Kevin Klann, Christian Münch
Published in: Journal of Cellular Biochemistry, 2022, ISSN 1097-4644
Publisher: Wiley
DOI: 10.1002/jcb.30225

Omics-based approaches for the systematic profiling of mitochondrial biology

Author(s): Jasmin Adriana Schäfer, F.X. Reymond Sutandy, Christian Münch
Published in: Molecular Cell, Issue 83, 2024, Page(s) 911-926, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.02.015

Non-peer reviewed articles (1)

The beginning of a new era: pioneering direct screens for RNA modulators

Author(s): F. X. Reymond Sutandy, Rebecca George Tharyan, Christian Münch
Published in: Signal Transduction and Targeted Therapy, Issue 7, 2022, ISSN 2059-3635
Publisher: Nature Research
DOI: 10.1038/s41392-022-01069-w