Cellular modulation by the mitochondrial unfolded protein response

Informazioni relative al progetto

mitoUPR

ID dell’accordo di sovvenzione: 803565

DOI 10.3030/803565

Data della firma CE 26 Ottobre 2018

Data di avvio 1 Febbraio 2019

Data di completamento 31 Luglio 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 437 500,00

Contributo UE € 1 437 500,00

Coordinato da

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany

Pubblicazioni

Peer reviewed articles (12)

A cytosolic surveillance mechanism activates the mitochondrial UPR

Autori: F. X. Reymond Sutandy, Ines Gößner, Georg Tascher & Christian Münch
Pubblicato in: Nature, Numero 618, 2023, Pagina/e 849–854, ISSN 1476-4687
Editore: Springer Nature
DOI: 10.1038/s41586-023-06142-0

Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells

Autori: Aneesha Kohli, Lucie Sauerhering, Sarah K Fehling, Kevin Klann, Helmut Geiger, Stephan Becker, Benjamin Koch, Patrick C Baer, Thomas Strecker, Christian Münch
Pubblicato in: Life Science Alliance, 2022, ISSN 2575-1077
Editore: Life Science Alliance
DOI: 10.26508/lsa.202201371

Monitoring Mitochondrial Protein Import Using Mitochondrial Targeting Sequence (MTS)-eGFP

Autori: Jonas B. Michaelis, Süleyman Bozkurt, Jasmin A. Schäfer, Christian Münch
Pubblicato in: bio-protocol, Numero Vol12, Numero 24, 2022, ISSN 2331-8325
Editore: bio-protocols Journal
DOI: 10.21769/bioprotoc.4578

CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2

Autori: Key, Jana; Gispert, Suzana; Koornneef, Lieke; Sleddens-Linkels, Esther; Kohli, Aneesha; Torres-Odio, Sylvia; Koepf, Gabriele; Amr, Shady; Reichlmeir, Marina; Harter, Patrick N.; West, Andrew Phillip; Münch, Christian; Baarends, Willy M.; Auburger, Georg; Gribnau, Joost
Pubblicato in: Cells, 12(1):52. Multidisciplinary Digital Publishing Institute (MDPI), Numero 5, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells12010052

Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication

Autori: Kevin Klann, Denisa Bojkova, Georg Tascher, Sandra Ciesek, Christian Münch, Jindrich Cinatl
Pubblicato in: Molecular Cell, Numero 80/1, 2020, Pagina/e 164-174.e4, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2020.08.006

Unbiased translation proteomics upon cell stress

Autori: Kevin Klann, Christian Münch
Pubblicato in: Molecular & Cellular Oncology, Numero 7/4, 2020, Pagina/e 1763150, ISSN 2372-3556
Editore: Taylor & Francis Online
DOI: 10.1080/23723556.2020.1763150

SARS-CoV-2 Variants Show Different Host Cell Proteome Profiles With Delayed Immune Response Activation in Omicron-Infected Cells

Autori: Melinda Metzler, Rebecca George Tharyan, Kevin Klann, Katharina Grikscheit, Denisa Bojkova, Jindrich Cinatl, Georg Tascher, Sandra Ciesek, Christian Münch
Pubblicato in: Molecular & Cellular Proteomics, Numero Vol22 Numero 5, 2023, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2023.100537

Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements

Autori: Kevin Klann, Christian Münch
Pubblicato in: Analytical Chemistry, Numero 92/12, 2020, Pagina/e 8041-8045, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.0c01749

Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α

Autori: Kevin Klann, Georg Tascher, Christian Münch
Pubblicato in: Molecular Cell, Numero 77/4, 2020, Pagina/e 913-925.e4, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.11.010

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

Autori: Denisa Bojkova, Kevin Klann, Benjamin Koch, Marek Widera, David Krause, Sandra Ciesek, Jindrich Cinatl, Christian Münch
Pubblicato in: Nature, Numero 583/7816, 2020, Pagina/e 469-472, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2332-7

Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery

Autori: Jasmin Adriana Schäfer, Süleyman Bozkurt, Jonas B. Michaelis, Kevin Klann, Christian Münch
Pubblicato in: Molecular Cell, 2022, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2021.11.004

PBLMM: Peptide‐based linear mixed models for differential expression analysis of shotgun proteomics data

Autori: Kevin Klann, Christian Münch
Pubblicato in: Journal of Cellular Biochemistry, 2022, ISSN 1097-4644
Editore: Wiley
DOI: 10.1002/jcb.30225