Cellular modulation by the mitochondrial unfolded protein response

Información del proyecto

mitoUPR

Identificador del acuerdo de subvención: 803565

DOI 10.3030/803565

Fecha de la firma de la CE 26 Octubre 2018

Fecha de inicio 1 Febrero 2019

Fecha de finalización 31 Julio 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 1 437 500,00

Aportación de la UE € 1 437 500,00

Coordinado por

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany

Publicaciones

Peer reviewed articles (12)

A cytosolic surveillance mechanism activates the mitochondrial UPR

Autores: F. X. Reymond Sutandy, Ines Gößner, Georg Tascher & Christian Münch
Publicado en: Nature, Edición 618, 2023, Página(s) 849–854, ISSN 1476-4687
Editor: Springer Nature
DOI: 10.1038/s41586-023-06142-0

Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells

Autores: Aneesha Kohli, Lucie Sauerhering, Sarah K Fehling, Kevin Klann, Helmut Geiger, Stephan Becker, Benjamin Koch, Patrick C Baer, Thomas Strecker, Christian Münch
Publicado en: Life Science Alliance, 2022, ISSN 2575-1077
Editor: Life Science Alliance
DOI: 10.26508/lsa.202201371

Monitoring Mitochondrial Protein Import Using Mitochondrial Targeting Sequence (MTS)-eGFP

Autores: Jonas B. Michaelis, Süleyman Bozkurt, Jasmin A. Schäfer, Christian Münch
Publicado en: bio-protocol, Edición Vol12, Edición 24, 2022, ISSN 2331-8325
Editor: bio-protocols Journal
DOI: 10.21769/bioprotoc.4578

CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2

Autores: Key, Jana; Gispert, Suzana; Koornneef, Lieke; Sleddens-Linkels, Esther; Kohli, Aneesha; Torres-Odio, Sylvia; Koepf, Gabriele; Amr, Shady; Reichlmeir, Marina; Harter, Patrick N.; West, Andrew Phillip; Münch, Christian; Baarends, Willy M.; Auburger, Georg; Gribnau, Joost
Publicado en: Cells, 12(1):52. Multidisciplinary Digital Publishing Institute (MDPI), Edición 5, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells12010052

Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication

Autores: Kevin Klann, Denisa Bojkova, Georg Tascher, Sandra Ciesek, Christian Münch, Jindrich Cinatl
Publicado en: Molecular Cell, Edición 80/1, 2020, Página(s) 164-174.e4, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2020.08.006

Unbiased translation proteomics upon cell stress

Autores: Kevin Klann, Christian Münch
Publicado en: Molecular & Cellular Oncology, Edición 7/4, 2020, Página(s) 1763150, ISSN 2372-3556
Editor: Taylor & Francis Online
DOI: 10.1080/23723556.2020.1763150

SARS-CoV-2 Variants Show Different Host Cell Proteome Profiles With Delayed Immune Response Activation in Omicron-Infected Cells

Autores: Melinda Metzler, Rebecca George Tharyan, Kevin Klann, Katharina Grikscheit, Denisa Bojkova, Jindrich Cinatl, Georg Tascher, Sandra Ciesek, Christian Münch
Publicado en: Molecular & Cellular Proteomics, Edición Vol22 Edición 5, 2023, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2023.100537

Instrument Logic Increases Identifications during Mutliplexed Translatome Measurements

Autores: Kevin Klann, Christian Münch
Publicado en: Analytical Chemistry, Edición 92/12, 2020, Página(s) 8041-8045, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.0c01749

Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α

Autores: Kevin Klann, Georg Tascher, Christian Münch
Publicado en: Molecular Cell, Edición 77/4, 2020, Página(s) 913-925.e4, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2019.11.010

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

Autores: Denisa Bojkova, Kevin Klann, Benjamin Koch, Marek Widera, David Krause, Sandra Ciesek, Jindrich Cinatl, Christian Münch
Publicado en: Nature, Edición 583/7816, 2020, Página(s) 469-472, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2332-7

Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery

Autores: Jasmin Adriana Schäfer, Süleyman Bozkurt, Jonas B. Michaelis, Kevin Klann, Christian Münch
Publicado en: Molecular Cell, 2022, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2021.11.004

PBLMM: Peptide‐based linear mixed models for differential expression analysis of shotgun proteomics data

Autores: Kevin Klann, Christian Münch
Publicado en: Journal of Cellular Biochemistry, 2022, ISSN 1097-4644
Editor: Wiley
DOI: 10.1002/jcb.30225