Descripción del proyecto
Tratamiento basado en la estratificación de pacientes con traumatismos craneoencefálicos
Los traumatismos craneoencefálicos (TCE) afectan a aproximadamente 1,8 millones de personas en Europa cada año. El actual sistema de estratificación de pacientes se basa en la gravedad de los síntomas para su diagnóstico, pronóstico y tratamiento. Sin embargo, dicho sistema no permite predecir el desenlace clínico a largo plazo tras un TCE. La principal hipótesis del proyecto financiado con fondos europeos NEUROPRECISE es que los TCE generan una respuesta neuroesteroide con variabilidad específica que guarda relación con el curso de la recuperación. Los investigadores del proyecto proponen un estudio longitudinal para caracterizar la respuesta neuroesteroide a TCE en relación con la edad y el sexo y seguirán analizando las diferencias en la respuesta neuroesteroide de tratamientos agudos personalizados y la prevención de deficiencias duraderas en un modelo murino. NEUROPRECISE tratará de superar los obstáculos para el tratamiento del TCE estableciendo formas de estratificar los pacientes en función de las diferencias específicas a la respuesta a TCE.
Objetivo
Traumatic brain injury (TBI) is very common and affects 1.8 million Europeans seeking medical help each year. TBI is a major challenge for healthcare providers and poses an enormous economic burden. For decades, TBI has been characterized by severity of symptoms for diagnosis, prognosis, and therapy. However, this classification system is limited since it does not allow to predict long-term outcome after TBI. This state of affairs thus hinders the advancement of TBI research and the development of therapies. The field is thus in dire need of a novel understanding and classification of the individual’s response to brain injury and, most importantly, a fresh perspective on potential targets for effective treatment and prevention of long-term impairment.
My main hypothesis is that brain injury leads to a neurosteroid response with inter-individual variability and that this response is associated with the trajectory of recovery. I further hypothesize, that the most vulnerable patient cohorts, such as adolescent girls, show distinct patterns of neurosteroid response associated with an increased risk for persistent symptoms.
NEUROPRECISE proposes a longitudinal cohort study 1) to characterize neurosteroid response with respect to age and sex in children and adolescents with TBI, 2) to evaluate the association of the neuroimaging derived individual injury profile with neurosteroid response, and 3) to explore individual differences in neurosteroid response as a potential target for acute therapy and prevention of chronic symptoms with respect to age and sex in a rodent model.
NEUROPRECISE will overcome a critical barrier towards the treatment of TBI by establishing a novel, biological-driven way to stratify TBI patients based on inter-individual differences in the response to TBI. By exploring the individual neurosteroid response as potential therapeutic target, NEUROPRECISE will bring the power of precision medicine to neurotrauma research.
Ámbito científico
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Régimen de financiación
ERC-STG - Starting GrantInstitución de acogida
80539 Muenchen
Alemania