Understanding the invasive nature of paediatric high-grade brain tumours
Diffuse intrinsic pontine glioma (DIPG) is an aggressive childhood cancer of the brain stem. It is a terminal illness with a median overall survival of 9 months. The EU-funded CANCER INVASION project aims to understand the mechanisms driving the invasive growth of DIPG. The researchers will employ state-of-the-art imaging and transcriptomics to investigate murine models of the disease to gain knowledge on the progression of DIPG in the developing brain. The implementation of large-scale single-cell resolution 3D imaging and intravital microscopy will enable imaging of tumour cell behaviour in living mice. The project will provide fundamental knowledge about the invasion mechanisms of cancer cells that govern DIPG spreading and may identify new potential therapeutic targets for this deadly disease.
Fields of science
Funding SchemeERC-STG - Starting Grant
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