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Deciphering and targeting the invasive nature of Diffuse Intrinsic Pontine Glioma

Project description

Understanding the invasive nature of paediatric high-grade brain tumours

Diffuse intrinsic pontine glioma (DIPG) is an aggressive childhood cancer of the brain stem. It is a terminal illness with a median overall survival of 9 months. The EU-funded CANCER INVASION project aims to understand the mechanisms driving the invasive growth of DIPG. The researchers will employ state-of-the-art imaging and transcriptomics to investigate murine models of the disease to gain knowledge on the progression of DIPG in the developing brain. The implementation of large-scale single-cell resolution 3D imaging and intravital microscopy will enable imaging of tumour cell behaviour in living mice. The project will provide fundamental knowledge about the invasion mechanisms of cancer cells that govern DIPG spreading and may identify new potential therapeutic targets for this deadly disease.

Host institution

PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Net EU contribution
€ 1 500 000,00
Address
Heidelberglaan 25
3584CS Utrecht
Netherlands

See on map

Region
West-Nederland Utrecht Utrecht
Activity type
Other
Other funding
€ 1 500 000,00

Beneficiaries (1)

PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands
Net EU contribution
€ 1 500 000,00
Address
Heidelberglaan 25
3584CS Utrecht

See on map

Region
West-Nederland Utrecht Utrecht
Activity type
Other
Other funding
€ 1 500 000,00