Directly reprogrammed renal cells for targeted medicine

Project Information

DiRECT

Grant agreement ID: 804474

DOI

10.3030/804474

Project closed

EC signature date 17 October 2018

Start date 1 March 2019

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 917,00

EU contribution

€ 1 499 917,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

SCD5 Regulation by VHL Affects Cell Proliferation and Lipid Homeostasis in ccRCC

Author(s): Athina Ganner, Antonia Philipp, Simon Lagies, Laura Wingendorf, Lu Wang, Felicitas Pilz, Thomas Welte, Kelli Grand, Soeren S. Lienkamp, Marinella Klein, Bernd Kammerer, Ian J. Frew, Gerd Walz, Elke Neumann-Haefelin
Published in: Cells, Issue 12, 2025, Page(s) 835, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12060835

Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A

Author(s): Valentina Marchesin; Albert Pérez-Martí; Gwenn Le Meur; Roman Pichler; Kelli Grand; Enriko D. Klootwijk; Anne Kesselheim; Robert Kleta; Soeren Lienkamp; Matias Simons
Published in: Cell Reports, Issue 1, 2020, Page(s) Elsevier, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.5167/uzh-179851

Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease

Author(s): Maike Getwan, Anselm Hoppmann, Pascal Schlosser, Kelli Grand, Weiting Song, Rebecca Diehl, Sophie Schroda, Florian Heeg, Konstantin Deutsch, Friedhelm Hildebrandt, Ekkehart Lausch, Anna Köttgen, Soeren S. Lienkamp
Published in: Proceedings of the National Academy of Sciences, Issue 118/39, 2021, Page(s) e2106770118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2106770118

Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis

Author(s): Eszter Banki, Viktoria Fisi, Sandra Moser, Agnieszka Wengi, Monique Carrel, Dominique Loffing-Cueni, David Penton, Denise V. Kratschmar, Ludovica Rizzo, Soeren Lienkamp, Alex Odermatt, Markus M. Rinschen, Johannes Loffing
Published in: Kidney International, Issue 100, 2022, Page(s) 850-869, ISSN 0085-2538
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2021.06.030

Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples

Author(s): Nikita Vladimirov, Fabian F. Voigt, Thomas Naert, Gabriela R. Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther Stoeckli, Laura Baudis, Soeren S. Lienkamp, Fritjof Helmchen
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-46770-2

Tuning the 3D microenvironment of reprogrammed tubule cells enhances biomimetic modeling of polycystic kidney disease

Author(s): Pichler, Roman, Ludovica Rizzo, Kevin Tröndle, Michaela Bühler, Hanna Brucker, Anna-Lena Müller, Kelli Grand, Silvia Farè, Amandine Viau, Michael M. Kaminski, E. Wolfgang Kuehn, Fritz Koch, Stefan Zimmermann, Peter Koltay, and Soeren S. Lienkamp
Published in: Biomaterials, 2022, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2022.121910

Kidney Development: Recent Insights from Technological Advances

Author(s): Ruth Röck; Ludovica Rizzo; Soeren S. Lienkamp
Published in: Crossref, Issue 7, 2022, ISSN 1548-9213
Publisher: American Physiological Society
DOI: 10.1152/physiol.00041.2021

Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development

Author(s): Fabiola Ceroni, Munevver B. Cicekdal, Richard Holt, Elena Sorokina, Nicolas Chassaing, Samuel Clokie, Thomas Naert, Lidiya V. Talbot, Sanaa Muheisen, Dorine A. Bax, Yesim Kesim, Emma C. Kivuva, Catherine Vincent-Delorme, Soeren S. Lienkamp, Julie Plaisancié, Elfride De Baere, Patrick Calvas, Kris Vleminckx, Elena V. Semina, Nicola K. Ragge
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53553-2

Reflective multi-immersion microscope objectives inspired by the Schmidt telescope

Author(s): Voigt, Fabian F., Anna Maria Reuss, Thomas Naert, Sven Hildebrand, Martina Schaettin, Adriana L. Hotz, Lachlan Whitehead, Armin Bahl, Stephan C. F. Neuhauss, Alard Roebroeck, Esther T. Stoeckli, Soeren S. Lienkamp, Adriano Aguzzi, and Fritjof Helmchen
Published in: Nature Biotechnology, 2023, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-023-01717-8

Flow induces common and specific transcriptional changes in renal tubular epithelial cells involving the <scp>PI3K</scp> pathway

Author(s): Kevin Tröndle, Ludovica Rizzo, Roman Pichler, Stefan Zimmermann, Soeren S. Lienkamp
Published in: The FASEB Journal, Issue 38, 2025, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202300834r

HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes

Author(s): Kelli Grand, Martine Stoltz, Ludovica Rizzo, Ruth Röck, Michael M Kaminski, Gabriela Salinas, Maike Getwan, Thomas Naert, Roman Pichler, Soeren S Lienkamp
Published in: J Am Soc Nephrol, 2022, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2022010076

Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

Author(s): Albert Pérez-Martí; Suresh Ramakrishnan; Jiayi Li; Aurelien Dugourd; Martijn R Molenaar; Luigi R De La Motte; Kelli Grand; Anis Mansouri; Mélanie Parisot; Soeren S Lienkamp; Julio Saez-Rodriguez; Matias Simons
Published in: eLife, Issue 8, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.74391

Deep Learning-Assisted Nephrotoxicity Testing with Bioprinted Renal Spheroids

Author(s): Kevin Tröndle, Guilherme Miotto, Ludovica Rizzo, Roman Pichler, Fritz Koch, Peter Koltay, Roland Zengerle, Soeren S. Lienkamp, Sabrina Kartmann, Stefan Zimmermann
Published in: International Journal of Bioprinting, Issue 8, 2024, Page(s) 528, ISSN 2424-7723
Publisher: AccScience Publishing (ASP)
DOI: 10.18063/ijb.v8i2.528

Deep learning is widely applicable to phenotyping embryonic development and disease

Author(s): Thomas Naert; Özgün Çiçek; Paulina Ogar; Max Bürgi; Nikko-Ideen Shaidani; Michael M. Kaminski; Michael M. Kaminski; Yuxiao Xu; Kelli Grand; Marko Vujanovic; Daniel Prata; Friedhelm Hildebrandt; Thomas Brox; Olaf Ronneberger; Fabian F. Voigt; Fritjof Helmchen; Johannes Loffing; Marko E. Horb; Helen Rankin Willsey; Soeren S. Lienkamp
Published in: Development, Issue 10, 2021, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.199664

Scalable fabrication of renal spheroids and nephron-like tubules by bioprinting and controlled self-assembly of epithelial cells

Author(s): Kevin Tröndle, Ludovica Rizzo, Roman Pichler, Fritz Koch, Ahmad Itani, Roland Zengerle, Soeren S Lienkamp, Peter Koltay, Stefan Zimmermann
Published in: Biofabrication, Issue 13/3, 2021, Page(s) 035019, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.1088/1758-5090/abe185

Metabolic and Lipidomic Assessment of Kidney Cells Exposed to Nephrotoxic Vancomycin Dosages

Author(s): Simon Lagies, Roman Pichler, Georg Vladimirov, Jana Gawron, Fabian Bäzner, Annabell Schreiner, Dajana Kadena, Dietmar A. Plattner, Soeren S. Lienkamp, Bernd Kammerer
Published in: International Journal of Molecular Sciences, Issue 22/18, 2021, Page(s) 10111, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810111

Impact of Diabetic Stress Conditions on Renal Cell Metabolome

Author(s): Lagies, Bork, Kaminski, Troendle, Zimmermann, Huber, Walz, Lienkamp, Kammerer
Published in: Cells, Issue 8/10, 2019, Page(s) 1141, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells8101141

Other (3)

The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples

Author(s): Nikita Vladimirov, Fabian F. Voigt, Thomas Naert, Gabriela R. Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther Stoeckli, Laura Baudis, Soeren S. Lienkamp, Fritjof Helmchen
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.06.16.545256

Increasing triacylglycerol formation and lipid storage by unsaturated lipids protects renal proximal tubules in diabetes

Author(s): Albert Pérez-Martí, Suresh Ramakrishnan, Jiayi Li, Aurelien Dugourd, Martijn R. Molenaar, Luigi R. De La Motte, Kelli Grand, Anis Mansouri, Mélanie Parisot, Soeren S. Lienkamp, Julio Saez-Rodriguez, Matias Simons
Published in: bioRxiv, 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.09.07.459360

Pythia: Non-random DNA repair allows predictable CRISPR/Cas9 integration and gene editing

Author(s): Thomas Naert, Taiyo Yamamoto, Shuting Han, Melanie Horn, Phillip Bethge, Nikita Vladimirov, Fabian F. Voigt, Joana Figueiro-Silva, Ruxandra Bachmann-Gagescu, Fritjof Helmchen, Soeren S. Lienkamp
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.23.614424

Intellectual Property Rights

Patent (1)

MICROHOMOLOGY MEDIATED INTEGRATION OF CARGO NUCLEIC ACID MOLECULES

Application/Publication number: 20 24073195
Date: 2024-08-19
Applicant(s): UNIVERSITAT ZURICH