Directly reprogrammed renal cells for targeted medicine

Información del proyecto

DiRECT

Identificador del acuerdo de subvención: 804474

DOI

10.3030/804474

Proyecto cerrado

Fecha de la firma de la CE 17 Octubre 2018

Fecha de inicio 1 Marzo 2019

Fecha de finalización 28 Febrero 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 917,00

Aportación de la UE

€ 1 499 917,00

Coordinado por

UNIVERSITAT ZURICH
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (17)

SCD5 Regulation by VHL Affects Cell Proliferation and Lipid Homeostasis in ccRCC

Autores: Athina Ganner, Antonia Philipp, Simon Lagies, Laura Wingendorf, Lu Wang, Felicitas Pilz, Thomas Welte, Kelli Grand, Soeren S. Lienkamp, Marinella Klein, Bernd Kammerer, Ian J. Frew, Gerd Walz, Elke Neumann-Haefelin
Publicado en: Cells, Edición 12, 2025, Página(s) 835, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells12060835

Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A

Autores: Valentina Marchesin; Albert Pérez-Martí; Gwenn Le Meur; Roman Pichler; Kelli Grand; Enriko D. Klootwijk; Anne Kesselheim; Robert Kleta; Soeren Lienkamp; Matias Simons
Publicado en: Cell Reports, Edición 1, 2020, Página(s) Elsevier, ISSN 2211-1247
Editor: Cell Press
DOI: 10.5167/uzh-179851

Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease

Autores: Maike Getwan, Anselm Hoppmann, Pascal Schlosser, Kelli Grand, Weiting Song, Rebecca Diehl, Sophie Schroda, Florian Heeg, Konstantin Deutsch, Friedhelm Hildebrandt, Ekkehart Lausch, Anna Köttgen, Soeren S. Lienkamp
Publicado en: Proceedings of the National Academy of Sciences, Edición 118/39, 2021, Página(s) e2106770118, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2106770118

Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis

Autores: Eszter Banki, Viktoria Fisi, Sandra Moser, Agnieszka Wengi, Monique Carrel, Dominique Loffing-Cueni, David Penton, Denise V. Kratschmar, Ludovica Rizzo, Soeren Lienkamp, Alex Odermatt, Markus M. Rinschen, Johannes Loffing
Publicado en: Kidney International, Edición 100, 2022, Página(s) 850-869, ISSN 0085-2538
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2021.06.030

Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples

Autores: Nikita Vladimirov, Fabian F. Voigt, Thomas Naert, Gabriela R. Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther Stoeckli, Laura Baudis, Soeren S. Lienkamp, Fritjof Helmchen
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-46770-2

Tuning the 3D microenvironment of reprogrammed tubule cells enhances biomimetic modeling of polycystic kidney disease

Autores: Pichler, Roman, Ludovica Rizzo, Kevin Tröndle, Michaela Bühler, Hanna Brucker, Anna-Lena Müller, Kelli Grand, Silvia Farè, Amandine Viau, Michael M. Kaminski, E. Wolfgang Kuehn, Fritz Koch, Stefan Zimmermann, Peter Koltay, and Soeren S. Lienkamp
Publicado en: Biomaterials, 2022, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2022.121910

Kidney Development: Recent Insights from Technological Advances

Autores: Ruth Röck; Ludovica Rizzo; Soeren S. Lienkamp
Publicado en: Crossref, Edición 7, 2022, ISSN 1548-9213
Editor: American Physiological Society
DOI: 10.1152/physiol.00041.2021

Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development

Autores: Fabiola Ceroni, Munevver B. Cicekdal, Richard Holt, Elena Sorokina, Nicolas Chassaing, Samuel Clokie, Thomas Naert, Lidiya V. Talbot, Sanaa Muheisen, Dorine A. Bax, Yesim Kesim, Emma C. Kivuva, Catherine Vincent-Delorme, Soeren S. Lienkamp, Julie Plaisancié, Elfride De Baere, Patrick Calvas, Kris Vleminckx, Elena V. Semina, Nicola K. Ragge
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-53553-2

Reflective multi-immersion microscope objectives inspired by the Schmidt telescope

Autores: Voigt, Fabian F., Anna Maria Reuss, Thomas Naert, Sven Hildebrand, Martina Schaettin, Adriana L. Hotz, Lachlan Whitehead, Armin Bahl, Stephan C. F. Neuhauss, Alard Roebroeck, Esther T. Stoeckli, Soeren S. Lienkamp, Adriano Aguzzi, and Fritjof Helmchen
Publicado en: Nature Biotechnology, 2023, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/s41587-023-01717-8

Flow induces common and specific transcriptional changes in renal tubular epithelial cells involving the <scp>PI3K</scp> pathway

Autores: Kevin Tröndle, Ludovica Rizzo, Roman Pichler, Stefan Zimmermann, Soeren S. Lienkamp
Publicado en: The FASEB Journal, Edición 38, 2025, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202300834r

HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes

Autores: Kelli Grand, Martine Stoltz, Ludovica Rizzo, Ruth Röck, Michael M Kaminski, Gabriela Salinas, Maike Getwan, Thomas Naert, Roman Pichler, Soeren S Lienkamp
Publicado en: J Am Soc Nephrol, 2022, ISSN 1046-6673
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2022010076

Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

Autores: Albert Pérez-Martí; Suresh Ramakrishnan; Jiayi Li; Aurelien Dugourd; Martijn R Molenaar; Luigi R De La Motte; Kelli Grand; Anis Mansouri; Mélanie Parisot; Soeren S Lienkamp; Julio Saez-Rodriguez; Matias Simons
Publicado en: eLife, Edición 8, 2022, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.74391

Deep Learning-Assisted Nephrotoxicity Testing with Bioprinted Renal Spheroids

Autores: Kevin Tröndle, Guilherme Miotto, Ludovica Rizzo, Roman Pichler, Fritz Koch, Peter Koltay, Roland Zengerle, Soeren S. Lienkamp, Sabrina Kartmann, Stefan Zimmermann
Publicado en: International Journal of Bioprinting, Edición 8, 2024, Página(s) 528, ISSN 2424-7723
Editor: AccScience Publishing (ASP)
DOI: 10.18063/ijb.v8i2.528

Deep learning is widely applicable to phenotyping embryonic development and disease

Autores: Thomas Naert; Özgün Çiçek; Paulina Ogar; Max Bürgi; Nikko-Ideen Shaidani; Michael M. Kaminski; Michael M. Kaminski; Yuxiao Xu; Kelli Grand; Marko Vujanovic; Daniel Prata; Friedhelm Hildebrandt; Thomas Brox; Olaf Ronneberger; Fabian F. Voigt; Fritjof Helmchen; Johannes Loffing; Marko E. Horb; Helen Rankin Willsey; Soeren S. Lienkamp
Publicado en: Development, Edición 10, 2021, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.199664

Scalable fabrication of renal spheroids and nephron-like tubules by bioprinting and controlled self-assembly of epithelial cells

Autores: Kevin Tröndle, Ludovica Rizzo, Roman Pichler, Fritz Koch, Ahmad Itani, Roland Zengerle, Soeren S Lienkamp, Peter Koltay, Stefan Zimmermann
Publicado en: Biofabrication, Edición 13/3, 2021, Página(s) 035019, ISSN 1758-5082
Editor: IOS Press
DOI: 10.1088/1758-5090/abe185

Metabolic and Lipidomic Assessment of Kidney Cells Exposed to Nephrotoxic Vancomycin Dosages

Autores: Simon Lagies, Roman Pichler, Georg Vladimirov, Jana Gawron, Fabian Bäzner, Annabell Schreiner, Dajana Kadena, Dietmar A. Plattner, Soeren S. Lienkamp, Bernd Kammerer
Publicado en: International Journal of Molecular Sciences, Edición 22/18, 2021, Página(s) 10111, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810111

Impact of Diabetic Stress Conditions on Renal Cell Metabolome

Autores: Lagies, Bork, Kaminski, Troendle, Zimmermann, Huber, Walz, Lienkamp, Kammerer
Publicado en: Cells, Edición 8/10, 2019, Página(s) 1141, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells8101141

Other (3)

The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples

Autores: Nikita Vladimirov, Fabian F. Voigt, Thomas Naert, Gabriela R. Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther Stoeckli, Laura Baudis, Soeren S. Lienkamp, Fritjof Helmchen
Publicado en: bioRxiv, 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.06.16.545256

Increasing triacylglycerol formation and lipid storage by unsaturated lipids protects renal proximal tubules in diabetes

Autores: Albert Pérez-Martí, Suresh Ramakrishnan, Jiayi Li, Aurelien Dugourd, Martijn R. Molenaar, Luigi R. De La Motte, Kelli Grand, Anis Mansouri, Mélanie Parisot, Soeren S. Lienkamp, Julio Saez-Rodriguez, Matias Simons
Publicado en: bioRxiv, 2022
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.09.07.459360

Pythia: Non-random DNA repair allows predictable CRISPR/Cas9 integration and gene editing

Autores: Thomas Naert, Taiyo Yamamoto, Shuting Han, Melanie Horn, Phillip Bethge, Nikita Vladimirov, Fabian F. Voigt, Joana Figueiro-Silva, Ruxandra Bachmann-Gagescu, Fritjof Helmchen, Soeren S. Lienkamp
Publicado en: bioRxiv, 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.23.614424

Derechos de propiedad intelectual

Patent (1)

MICROHOMOLOGY MEDIATED INTEGRATION OF CARGO NUCLEIC ACID MOLECULES

Número de solicitud/publicación: 20 24073195
Fecha: 2024-08-19
Solicitante(s): UNIVERSITAT ZURICH