Directly reprogrammed renal cells for targeted medicine

Informazioni relative al progetto

DiRECT

ID dell’accordo di sovvenzione: 804474

DOI

10.3030/804474

Progetto chiuso

Data della firma CE 17 Ottobre 2018

Data di avvio 1 Marzo 2019

Data di completamento 28 Febbraio 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 499 917,00

Contributo UE

€ 1 499 917,00

Coordinato da

UNIVERSITAT ZURICH
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (17)

SCD5 Regulation by VHL Affects Cell Proliferation and Lipid Homeostasis in ccRCC

Autori: Athina Ganner, Antonia Philipp, Simon Lagies, Laura Wingendorf, Lu Wang, Felicitas Pilz, Thomas Welte, Kelli Grand, Soeren S. Lienkamp, Marinella Klein, Bernd Kammerer, Ian J. Frew, Gerd Walz, Elke Neumann-Haefelin
Pubblicato in: Cells, Numero 12, 2025, Pagina/e 835, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells12060835

Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A

Autori: Valentina Marchesin; Albert Pérez-Martí; Gwenn Le Meur; Roman Pichler; Kelli Grand; Enriko D. Klootwijk; Anne Kesselheim; Robert Kleta; Soeren Lienkamp; Matias Simons
Pubblicato in: Cell Reports, Numero 1, 2020, Pagina/e Elsevier, ISSN 2211-1247
Editore: Cell Press
DOI: 10.5167/uzh-179851

Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease

Autori: Maike Getwan, Anselm Hoppmann, Pascal Schlosser, Kelli Grand, Weiting Song, Rebecca Diehl, Sophie Schroda, Florian Heeg, Konstantin Deutsch, Friedhelm Hildebrandt, Ekkehart Lausch, Anna Köttgen, Soeren S. Lienkamp
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 118/39, 2021, Pagina/e e2106770118, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2106770118

Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis

Autori: Eszter Banki, Viktoria Fisi, Sandra Moser, Agnieszka Wengi, Monique Carrel, Dominique Loffing-Cueni, David Penton, Denise V. Kratschmar, Ludovica Rizzo, Soeren Lienkamp, Alex Odermatt, Markus M. Rinschen, Johannes Loffing
Pubblicato in: Kidney International, Numero 100, 2022, Pagina/e 850-869, ISSN 0085-2538
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.kint.2021.06.030

Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples

Autori: Nikita Vladimirov, Fabian F. Voigt, Thomas Naert, Gabriela R. Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther Stoeckli, Laura Baudis, Soeren S. Lienkamp, Fritjof Helmchen
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-46770-2

Tuning the 3D microenvironment of reprogrammed tubule cells enhances biomimetic modeling of polycystic kidney disease

Autori: Pichler, Roman, Ludovica Rizzo, Kevin Tröndle, Michaela Bühler, Hanna Brucker, Anna-Lena Müller, Kelli Grand, Silvia Farè, Amandine Viau, Michael M. Kaminski, E. Wolfgang Kuehn, Fritz Koch, Stefan Zimmermann, Peter Koltay, and Soeren S. Lienkamp
Pubblicato in: Biomaterials, 2022, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2022.121910

Kidney Development: Recent Insights from Technological Advances

Autori: Ruth Röck; Ludovica Rizzo; Soeren S. Lienkamp
Pubblicato in: Crossref, Numero 7, 2022, ISSN 1548-9213
Editore: American Physiological Society
DOI: 10.1152/physiol.00041.2021

Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development

Autori: Fabiola Ceroni, Munevver B. Cicekdal, Richard Holt, Elena Sorokina, Nicolas Chassaing, Samuel Clokie, Thomas Naert, Lidiya V. Talbot, Sanaa Muheisen, Dorine A. Bax, Yesim Kesim, Emma C. Kivuva, Catherine Vincent-Delorme, Soeren S. Lienkamp, Julie Plaisancié, Elfride De Baere, Patrick Calvas, Kris Vleminckx, Elena V. Semina, Nicola K. Ragge
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-53553-2

Reflective multi-immersion microscope objectives inspired by the Schmidt telescope

Autori: Voigt, Fabian F., Anna Maria Reuss, Thomas Naert, Sven Hildebrand, Martina Schaettin, Adriana L. Hotz, Lachlan Whitehead, Armin Bahl, Stephan C. F. Neuhauss, Alard Roebroeck, Esther T. Stoeckli, Soeren S. Lienkamp, Adriano Aguzzi, and Fritjof Helmchen
Pubblicato in: Nature Biotechnology, 2023, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-023-01717-8

Flow induces common and specific transcriptional changes in renal tubular epithelial cells involving the <scp>PI3K</scp> pathway

Autori: Kevin Tröndle, Ludovica Rizzo, Roman Pichler, Stefan Zimmermann, Soeren S. Lienkamp
Pubblicato in: The FASEB Journal, Numero 38, 2025, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202300834r

HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes

Autori: Kelli Grand, Martine Stoltz, Ludovica Rizzo, Ruth Röck, Michael M Kaminski, Gabriela Salinas, Maike Getwan, Thomas Naert, Roman Pichler, Soeren S Lienkamp
Pubblicato in: J Am Soc Nephrol, 2022, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2022010076

Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

Autori: Albert Pérez-Martí; Suresh Ramakrishnan; Jiayi Li; Aurelien Dugourd; Martijn R Molenaar; Luigi R De La Motte; Kelli Grand; Anis Mansouri; Mélanie Parisot; Soeren S Lienkamp; Julio Saez-Rodriguez; Matias Simons
Pubblicato in: eLife, Numero 8, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.74391

Deep Learning-Assisted Nephrotoxicity Testing with Bioprinted Renal Spheroids

Autori: Kevin Tröndle, Guilherme Miotto, Ludovica Rizzo, Roman Pichler, Fritz Koch, Peter Koltay, Roland Zengerle, Soeren S. Lienkamp, Sabrina Kartmann, Stefan Zimmermann
Pubblicato in: International Journal of Bioprinting, Numero 8, 2024, Pagina/e 528, ISSN 2424-7723
Editore: AccScience Publishing (ASP)
DOI: 10.18063/ijb.v8i2.528

Deep learning is widely applicable to phenotyping embryonic development and disease

Autori: Thomas Naert; Özgün Çiçek; Paulina Ogar; Max Bürgi; Nikko-Ideen Shaidani; Michael M. Kaminski; Michael M. Kaminski; Yuxiao Xu; Kelli Grand; Marko Vujanovic; Daniel Prata; Friedhelm Hildebrandt; Thomas Brox; Olaf Ronneberger; Fabian F. Voigt; Fritjof Helmchen; Johannes Loffing; Marko E. Horb; Helen Rankin Willsey; Soeren S. Lienkamp
Pubblicato in: Development, Numero 10, 2021, ISSN 0950-1991
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dev.199664

Scalable fabrication of renal spheroids and nephron-like tubules by bioprinting and controlled self-assembly of epithelial cells

Autori: Kevin Tröndle, Ludovica Rizzo, Roman Pichler, Fritz Koch, Ahmad Itani, Roland Zengerle, Soeren S Lienkamp, Peter Koltay, Stefan Zimmermann
Pubblicato in: Biofabrication, Numero 13/3, 2021, Pagina/e 035019, ISSN 1758-5082
Editore: IOS Press
DOI: 10.1088/1758-5090/abe185

Metabolic and Lipidomic Assessment of Kidney Cells Exposed to Nephrotoxic Vancomycin Dosages

Autori: Simon Lagies, Roman Pichler, Georg Vladimirov, Jana Gawron, Fabian Bäzner, Annabell Schreiner, Dajana Kadena, Dietmar A. Plattner, Soeren S. Lienkamp, Bernd Kammerer
Pubblicato in: International Journal of Molecular Sciences, Numero 22/18, 2021, Pagina/e 10111, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810111

Impact of Diabetic Stress Conditions on Renal Cell Metabolome

Autori: Lagies, Bork, Kaminski, Troendle, Zimmermann, Huber, Walz, Lienkamp, Kammerer
Pubblicato in: Cells, Numero 8/10, 2019, Pagina/e 1141, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells8101141

Other (3)

The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples

Autori: Nikita Vladimirov, Fabian F. Voigt, Thomas Naert, Gabriela R. Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther Stoeckli, Laura Baudis, Soeren S. Lienkamp, Fritjof Helmchen
Pubblicato in: bioRxiv, 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.06.16.545256

Increasing triacylglycerol formation and lipid storage by unsaturated lipids protects renal proximal tubules in diabetes

Autori: Albert Pérez-Martí, Suresh Ramakrishnan, Jiayi Li, Aurelien Dugourd, Martijn R. Molenaar, Luigi R. De La Motte, Kelli Grand, Anis Mansouri, Mélanie Parisot, Soeren S. Lienkamp, Julio Saez-Rodriguez, Matias Simons
Pubblicato in: bioRxiv, 2022
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.09.07.459360

Pythia: Non-random DNA repair allows predictable CRISPR/Cas9 integration and gene editing

Autori: Thomas Naert, Taiyo Yamamoto, Shuting Han, Melanie Horn, Phillip Bethge, Nikita Vladimirov, Fabian F. Voigt, Joana Figueiro-Silva, Ruxandra Bachmann-Gagescu, Fritjof Helmchen, Soeren S. Lienkamp
Pubblicato in: bioRxiv, 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.23.614424

Diritti di proprietà intellettuale

Patent (1)

MICROHOMOLOGY MEDIATED INTEGRATION OF CARGO NUCLEIC ACID MOLECULES

Numero candidatura/pubblicazione: 20 24073195
Data: 2024-08-19
Candidato/i: UNIVERSITAT ZURICH