Searching for novel strategies improving cancer immunotherapy

Project Information

STIMUNO

Grant agreement ID: 805038

DOI

10.3030/805038

Project closed

EC signature date 10 October 2018

Start date 1 March 2019

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 750,00

EU contribution

€ 1 498 750,00

Coordinated by

INSTYTUT MEDYCYNY DOSWIADCZALNEJ I KLINICZNEJ IM MIROSLAWA MOSSAKOWSKIEGO POLSKIEJ AKADEMII NAUK
Poland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Molecular Aspects of Resistance to Immunotherapies—Advances in Understanding and Management of Diffuse Large B-Cell Lymphoma

Author(s): Aleksandra Kusowska, Matylda Kubacz, Marta Krawczyk, Aleksander Slusarczyk, Magdalena Winiarska, Malgorzata Bobrowicz
Published in: International Journal of Molecular Sciences, Issue 23, 2025, Page(s) 1501, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031501

The Great War of Today: Modifications of CAR-T Cells to Effectively Combat Malignancies

Author(s): Andriy Zhylko, Magdalena Winiarska, Agnieszka Graczyk-Jarzynka
Published in: Cancers, Issue 12/8, 2020, Page(s) 2030, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082030

LILRB1-directed CAR-T cells for the treatment of hematological malignancies

Author(s): Katsiaryna Marhelava, Klaudyna Fidyt, Monika Pepek, Marta Krawczyk, Christopher Forcados, Agata Malinowska, Bianka Swiderska, Narcis Fernandez-Fuentes, Natalia Czerwik, Iwona Baranowska, Agnieszka Krzywdzinska, Lukasz Sedek, Lukasz Slota, Bartosz Perkowski, Alicia Villatoro, Thibault Leray, Ewa Lech-Maranda, Pablo Menendez, Else Marit Inderberg, Sébastien Wälchli, Magdalena Winiarska, Malgorzata
Published in: Leukemia, Issue 39, 2025, Page(s) 1395-1411, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-025-02580-z

Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin

Author(s): Joanna Domagala, Tomasz M. Grzywa, Iwona Baranowska, Magdalena Justyniarska, Ryan Tannir, Agnieszka Graczyk-Jarzynka, Aleksandra Kusowska, Maria Lecka, Marcin Poreba, Klaudyna Fidyt, Katsiaryna Marhelava, Zofia Pilch, Lea K. Picard, Tomasz Wegierski, Kamil Jastrzebski, Marta Krawczyk, Marta Klopotowska, Monika Granica, Doris Urlaub, Szymon Hajduk, Alexandra Neeser, Spencer Moros, Pawel Kozlowski,
Published in: Cancer Research, Issue 85, 2025, Page(s) 2448-2467, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-0749

PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells

Author(s): Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sébastien Wälchli, Magdalena Winiarska, Radoslaw Zagozdzon
Published in: Journal for ImmunoTherapy of Cancer, Issue 10, 2025, Page(s) e002500, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2021-002500

Correction: PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells

Author(s): Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sébastien Wälchli, Magdalena Winiarska, Radoslaw Zagozdzon
Published in: Journal for ImmunoTherapy of Cancer, Issue 10, 2025, Page(s) e002500corr1, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2021-002500corr1

The “Magic Bullet” Is Here? Cell-Based Immunotherapies for Hematological Malignancies in the Twilight of the Chemotherapy Era

Author(s): Nina Miazek-Zapala, Aleksander Slusarczyk, Aleksandra Kusowska, Piotr Zapala, Matylda Kubacz, Magdalena Winiarska, Malgorzata Bobrowicz
Published in: Cells, Issue 10/6, 2021, Page(s) 1511, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10061511

PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress

Author(s): Marta Klopotowska, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Agnieszka Kraft, Zofia Pilch, Andriy Zhylko, Malgorzata Firczuk, Iwona Baranowska, Michal Lazniewski, Dariusz Plewczynski, Agnieszka Goral, Karolina Soroczynska, Joanna Domagala, Katsiaryna Marhelava, Aleksander Slusarczyk, Kuba Retecki, Kavita Ramji, Marta Krawczyk, Madison N. Temples, Blanka Sharma, Mieszko Lachota, Herman Netskar,
Published in: Cancer Immunology Research, Issue 10, 2025, Page(s) 228-244, ISSN 2326-6066
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-20-1023

The race between 4-1BB- and CD28-based CD19 CAR-T products in the therapy of B-cell malignancies

Author(s): Marta Krawczyk, Magdalena Drużyńska, Emilia Bednarska, Magdalena Winiarska
Published in: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Issue 1881, 2026, Page(s) 189519, ISSN 0304-419X
Publisher: Elsevier BV
DOI: 10.1016/j.bbcan.2025.189519

In Vitro Diffuse Large B-Cell Lymphoma Cell Line Models as Tools to Investigate Novel Immunotherapeutic Strategies

Author(s): Matylda Kubacz, Aleksandra Kusowska, Magdalena Winiarska, Małgorzata Bobrowicz
Published in: Cancers, Issue 15, 2025, Page(s) 235, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010235

GPX4 is a key ferroptosis regulator orchestrating T cells and CAR-T-cells sensitivity to ferroptosis

Author(s): Marta Kłopotowska, Iwona Baranowska, Szymon Hajduk, Anna Jurga, Natalia Leśniowska, Michał Łaźniewski, Monika Granica, Marta Krawczyk, Milena Dziewicka, Agnieszka Graczyk, Jan Słupski, Radosław Zagożdżon, Dariusz Plewczynski, Magdalena Winiarska, Malgorzata Bajor
Published in: Cancer Immunology, Immunotherapy, Issue 74, 2025, ISSN 1432-0851
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00262-025-04133-w

The Tumor Microenvironment—A Metabolic Obstacle to NK Cells’ Activity

Author(s): Joanna Domagala, Mieszko Lachota, Marta Klopotowska, Agnieszka Graczyk-Jarzynka, Antoni Domagala, Andriy Zhylko, Karolina Soroczynska, Magdalena Winiarska
Published in: Cancers, Issue 12/12, 2020, Page(s) 3542, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123542

Prospects for NK Cell Therapy of Sarcoma

Author(s): Mieszko Lachota, Marianna Vincenti, Magdalena Winiarska, Kjetil Boye, Radosław Zagożdżon, Karl-Johan Malmberg
Published in: Cancers, Issue 12, 2025, Page(s) 3719, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123719