Searching for novel strategies improving cancer immunotherapy

Informazioni relative al progetto

STIMUNO

ID dell’accordo di sovvenzione: 805038

DOI

10.3030/805038

Progetto chiuso

Data della firma CE 10 Ottobre 2018

Data di avvio 1 Marzo 2019

Data di completamento 31 Dicembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 498 750,00

Contributo UE

€ 1 498 750,00

Coordinato da

INSTYTUT MEDYCYNY DOSWIADCZALNEJ I KLINICZNEJ IM MIROSLAWA MOSSAKOWSKIEGO POLSKIEJ AKADEMII NAUK
Poland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (13)

Molecular Aspects of Resistance to Immunotherapies—Advances in Understanding and Management of Diffuse Large B-Cell Lymphoma

Autori: Aleksandra Kusowska, Matylda Kubacz, Marta Krawczyk, Aleksander Slusarczyk, Magdalena Winiarska, Malgorzata Bobrowicz
Pubblicato in: International Journal of Molecular Sciences, Numero 23, 2025, Pagina/e 1501, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031501

The Great War of Today: Modifications of CAR-T Cells to Effectively Combat Malignancies

Autori: Andriy Zhylko, Magdalena Winiarska, Agnieszka Graczyk-Jarzynka
Pubblicato in: Cancers, Numero 12/8, 2020, Pagina/e 2030, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082030

LILRB1-directed CAR-T cells for the treatment of hematological malignancies

Autori: Katsiaryna Marhelava, Klaudyna Fidyt, Monika Pepek, Marta Krawczyk, Christopher Forcados, Agata Malinowska, Bianka Swiderska, Narcis Fernandez-Fuentes, Natalia Czerwik, Iwona Baranowska, Agnieszka Krzywdzinska, Lukasz Sedek, Lukasz Slota, Bartosz Perkowski, Alicia Villatoro, Thibault Leray, Ewa Lech-Maranda, Pablo Menendez, Else Marit Inderberg, Sébastien Wälchli, Magdalena Winiarska, Malgorzata
Pubblicato in: Leukemia, Numero 39, 2025, Pagina/e 1395-1411, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-025-02580-z

Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin

Autori: Joanna Domagala, Tomasz M. Grzywa, Iwona Baranowska, Magdalena Justyniarska, Ryan Tannir, Agnieszka Graczyk-Jarzynka, Aleksandra Kusowska, Maria Lecka, Marcin Poreba, Klaudyna Fidyt, Katsiaryna Marhelava, Zofia Pilch, Lea K. Picard, Tomasz Wegierski, Kamil Jastrzebski, Marta Krawczyk, Marta Klopotowska, Monika Granica, Doris Urlaub, Szymon Hajduk, Alexandra Neeser, Spencer Moros, Pawel Kozlowski,
Pubblicato in: Cancer Research, Numero 85, 2025, Pagina/e 2448-2467, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-0749

PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells

Autori: Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sébastien Wälchli, Magdalena Winiarska, Radoslaw Zagozdzon
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 10, 2025, Pagina/e e002500, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2021-002500

Correction: PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells

Autori: Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sébastien Wälchli, Magdalena Winiarska, Radoslaw Zagozdzon
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 10, 2025, Pagina/e e002500corr1, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2021-002500corr1

The “Magic Bullet” Is Here? Cell-Based Immunotherapies for Hematological Malignancies in the Twilight of the Chemotherapy Era

Autori: Nina Miazek-Zapala, Aleksander Slusarczyk, Aleksandra Kusowska, Piotr Zapala, Matylda Kubacz, Magdalena Winiarska, Malgorzata Bobrowicz
Pubblicato in: Cells, Numero 10/6, 2021, Pagina/e 1511, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10061511

PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress

Autori: Marta Klopotowska, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Agnieszka Kraft, Zofia Pilch, Andriy Zhylko, Malgorzata Firczuk, Iwona Baranowska, Michal Lazniewski, Dariusz Plewczynski, Agnieszka Goral, Karolina Soroczynska, Joanna Domagala, Katsiaryna Marhelava, Aleksander Slusarczyk, Kuba Retecki, Kavita Ramji, Marta Krawczyk, Madison N. Temples, Blanka Sharma, Mieszko Lachota, Herman Netskar,
Pubblicato in: Cancer Immunology Research, Numero 10, 2025, Pagina/e 228-244, ISSN 2326-6066
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-20-1023

The race between 4-1BB- and CD28-based CD19 CAR-T products in the therapy of B-cell malignancies

Autori: Marta Krawczyk, Magdalena Drużyńska, Emilia Bednarska, Magdalena Winiarska
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Numero 1881, 2026, Pagina/e 189519, ISSN 0304-419X
Editore: Elsevier BV
DOI: 10.1016/j.bbcan.2025.189519

In Vitro Diffuse Large B-Cell Lymphoma Cell Line Models as Tools to Investigate Novel Immunotherapeutic Strategies

Autori: Matylda Kubacz, Aleksandra Kusowska, Magdalena Winiarska, Małgorzata Bobrowicz
Pubblicato in: Cancers, Numero 15, 2025, Pagina/e 235, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15010235

GPX4 is a key ferroptosis regulator orchestrating T cells and CAR-T-cells sensitivity to ferroptosis

Autori: Marta Kłopotowska, Iwona Baranowska, Szymon Hajduk, Anna Jurga, Natalia Leśniowska, Michał Łaźniewski, Monika Granica, Marta Krawczyk, Milena Dziewicka, Agnieszka Graczyk, Jan Słupski, Radosław Zagożdżon, Dariusz Plewczynski, Magdalena Winiarska, Malgorzata Bajor
Pubblicato in: Cancer Immunology, Immunotherapy, Numero 74, 2025, ISSN 1432-0851
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s00262-025-04133-w

The Tumor Microenvironment—A Metabolic Obstacle to NK Cells’ Activity

Autori: Joanna Domagala, Mieszko Lachota, Marta Klopotowska, Agnieszka Graczyk-Jarzynka, Antoni Domagala, Andriy Zhylko, Karolina Soroczynska, Magdalena Winiarska
Pubblicato in: Cancers, Numero 12/12, 2020, Pagina/e 3542, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123542

Prospects for NK Cell Therapy of Sarcoma

Autori: Mieszko Lachota, Marianna Vincenti, Magdalena Winiarska, Kjetil Boye, Radosław Zagożdżon, Karl-Johan Malmberg
Pubblicato in: Cancers, Numero 12, 2025, Pagina/e 3719, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123719