Uncovering and engineering the principles governing evolution and cellular control of bioenergetic organelles

Información del proyecto

EvoConBiO

Identificador del acuerdo de subvención: 805046

DOI

10.3030/805046

Proyecto cerrado

Fecha de la firma de la CE 28 Septiembre 2018

Fecha de inicio 1 Julio 2019

Fecha de finalización 31 Mayo 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 417 862,00

Aportación de la UE

€ 1 417 862,00

Coordinado por

UNIVERSITETET I BERGEN
Norway

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

Publicaciones

Peer reviewed articles (40)

Avoiding misleading estimates using mtDNA heteroplasmy statistics to study bottleneck size and selection

Autores: Konstantinos Giannakis; Amanda K. Broz; Daniel B. Sloan; Iain G. Johnston
Publicado en: G3, Edición 13, 2023, Página(s) jkad068, ISSN 2160-1836
Editor: Genetics Society of America
DOI: 10.1101/2022.09.06.506828

Intracellular Energy Variability Modulates Cellular Decision-Making Capacity

Autores: R Kerr, S Jabbari, IG Johnston
Publicado en: Scientific Reports, Edición 91, 2019, Página(s) p20196, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-56587-5

Evolutionary inference across eukaryotes identifies universal features shaping organelle gene retention

Autores: Konstantinos Giannakis, Samuel J. Arrowsmith, Luke Richards, Sara Gasparini, Joanna M. Chustecki, Ellen C. Røyrvik, Iain G. Johnston
Publicado en: Cell Systems, Edición 13, 2022, Página(s) 874-884, ISSN 2405-4712
Editor: Elsevier
DOI: 10.1016/j.cels.2022.08.007

Sexually antagonistic evolution of mitochondrial and nuclear linkage

Autores: Arunas Radzvilavicius, Sean Layh, Matthew D. Hall, Damian K. Dowling, Iain G. Johnston
Publicado en: Journal of Evolutionary Biology, Edición 34, 2024, Página(s) 757-766, ISSN 1010-061X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jeb.13776

The Nitroplast and Its Relatives Support a Universal Model of Features Predicting Gene Retention in Endosymbiont and Organelle Genomes

Autores: Iain G Johnston
Publicado en: Genome Biology and Evolution, Edición 16, 2024, Página(s) evae132, ISSN 1759-6653
Editor: Oxford University Press
DOI: 10.1093/gbe/evae132

Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck.

Autores: David M. Edwards; Ellen C. Røyrvik; Joanna M. Chustecki; Konstantinos Giannakis; Robert C. Glastad; Arunas L. Radzvilavicius; Iain G. Johnston
Publicado en: PLoS Biology, Edición 19, 2020, Página(s) e3001153, ISSN 1544-9173
Editor: Public Library of Science
DOI: 10.1371/journal.pbio.3001153

Comparing structure and dynamics of transition graphs by the symmetric difference metric over an edge-filtration

Autores: Belén García Pascual, Lars M. Salbu, Jessica Renz, Konstantinos Giannakis, Iain G. Johnston
Publicado en: IEEE Access, Edición 12, 2025, Página(s) 81030, ISSN 2169-3536
Editor: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1101/2024.01.29.577802

Efficient inference of evolutionary and progressive dynamics on hypercubic transition graphs

Autores: Marcus T. Moen; Iain G. Johnston
Publicado en: Bioinformatics, Edición 39, 2023, Página(s) btac803, ISSN 1367-4811
Editor: Oxford University Press
DOI: 10.1101/2022.05.09.491130

ATP dependence of decision-making capacity in a fine-grained model of gene regulatory networks

Autores: Rajneesh Kumar, Iain G. Johnston
Publicado en: Journal of The Royal Society Interface, Edición 21, 2024, ISSN 1742-5662
Editor: The Royal Society
DOI: 10.1098/rsif.2024.0246

A Picture Guide to Cancer Progression and Evolutionary Accumulation Models: Systematic Critique, Plausible Interpretations, and Alternative Uses

Autores: Ramon Diaz-Uriarte, Iain G. Johnston
Publicado en: IEEE Access, Edición 13, 2025, Página(s) 62306-62340, ISSN 2169-3536
Editor: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2025.3558392

Stochastic organelle genome segregation through <i>Arabidopsis</i> development and reproduction

Autores: Amanda K. Broz; Daniel B. Sloan; Iain G. Johnston
Publicado en: New Phytologist, Edición 241, 2024, Página(s) 896-910, ISSN 0028-646X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/nph.19288

A hypercubic Mk model framework for capturing reversibility in disease, cancer, and evolutionary accumulation modelling

Autores: Iain G. Johnston, Ramon Diaz-Uriarte
Publicado en: Bioinformatics, Edición 41, 2024, Página(s) btae737, ISSN 1367-4811
Editor: Oxford University Press
DOI: 10.1101/2024.06.27.600959

Cellular and environmental dynamics influence species-specific extents of organelle gene retention

Autores: Belén García Pascual; Jan M. Nordbotten; Iain G. Johnston
Publicado en: Proceedings of the Royal Society B, Edición 290, 2023, Página(s) 20222140, ISSN 0962-8452
Editor: Royal Society of London
DOI: 10.1101/2022.10.17.512581

Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions

Autores: Robert C. Glastad; Iain G. Johnston
Publicado en: PLoS Computational Biology, Edición 19, 2023, Página(s) e1010953, ISSN 1553-734X
Editor: Public Library of Science
DOI: 10.1101/2022.06.27.497759

Estimating physical conditions supporting gradients of ATP concentration in the eukaryotic cell

Autores: Rajneesh Kumar, Iain G. Johnston
Publicado en: Biophysical Journal, Edición 2025, 2025, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2025.06.016

Collective mitochondrial dynamics resolve conflicting cellular tensions: From plants to general principles

Autores: Joanna M Chustecki, Iain G Johnston
Publicado en: Seminars in Cell & Developmental Biology, Edición 156, 2024, Página(s) 253-265, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2023.09.005

Clustering Large-Scale Biomedical Data to Model Dynamic Accumulation Processes in Disease Progression and Anti-Microbial Resistance Evolution

Autores: Kazeem A. Dauda, Olav N. L. Aga, Iain G. Johnston
Publicado en: IEEE Access, Edición 13, 2025, Página(s) 13816-13831, ISSN 2169-3536
Editor: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2025.3527715

HyperTraPS-CT: Inference and prediction for accumulation pathways with flexible data and model structures

Autores: Olav N. L. Aga, Morten Brun, Kazeem A. Dauda, Ramon Diaz-Uriarte, Konstantinos Giannakis, Iain G. Johnston
Publicado en: PLoS Computational Biology, Edición 20, 2025, Página(s) e10112393, ISSN 1553-7358
Editor: PLoS
DOI: 10.1101/2024.03.07.583841

Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease

Autores: Mona Synnøve Bjune, Laurence Lawrence-Archer, Johnny Laupsa-Borge, Cathrine Horn Sommersten, Adrian McCann, Robert Clay Glastad, Iain George Johnston, Matthias Kern, Matthias Blüher, Gunnar Mellgren, Simon N. Dankel
Publicado en: eBioMedicine, Edición 91, 2023, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104569

MtDNA sequence features associated with ‘selfish genomes’ predict tissue-specific segregation and reversion

Autores: Ellen C Røyrvik, Iain G Johnston
Publicado en: Nucleic Acids Research, Edición 48/15, 2020, Página(s) 8290-8301, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa622

Evolution and maintenance of mtDNA gene content across eukaryotes

Autores: Shibani Veeraragavan, Maria Johansen, Iain Johnston
Publicado en: Biochemical Journal, Edición 281, 2024, Página(s) 1015, ISSN 1470-8728
Editor: Portland Press
DOI: 10.32942/x2hs53

Exchange on dynamic encounter networks allows plant mitochondria to collect complete sets of mitochondrial DNA products despite their incomplete genomes

Autores: Konstantinos Giannakis; Joanna M. Chustecki; Iain G. Johnston
Publicado en: Quantitative Plant Biology, Edición 3, 2022, Página(s) e18, ISSN 2632-8828
Editor: Cambridge University Press
DOI: 10.1017/qpb.2022.15

Mitochondrial Network State Scales mtDNA Genetic Dynamics

Autores: Juvid Aryaman, Charlotte Bowles, Nick S. Jones, Iain G. Johnston
Publicado en: Genetics, Edición 212/4, 2019, Página(s) 1429-1443, ISSN 0016-6731
Editor: Genetics Society of America
DOI: 10.1534/genetics.119.302423

Intracellular Energy Variability Modulates Cellular Decision-Making Capacity

Autores: Iain G. Johnston; Iain G. Johnston; Ryan Kerr; Sara Jabbari
Publicado en: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019), Edición 1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1101/2019.12.13.875427

Ecological Predictors of Organelle Genome Evolution: Phylogenetic Correlations with Taxonomically Broad, Sparse, Unsystematized Data

Autores: Konstantinos Giannakis, Luke Richards, Iain G Johnston
Publicado en: Systematic Biology, Edición 73, 2024, Página(s) 419-433, ISSN 1063-5157
Editor: Taylor & Francis
DOI: 10.1093/sysbio/syae009

Evolving mtDNA populations within cells

Autores: Iain G. Johnston, Joerg P. Burgstaller
Publicado en: Biochemical Society Transactions, Edición 47/5, 2019, Página(s) 1367-1382, ISSN 0300-5127
Editor: Portland Press, Ltd.
DOI: 10.1042/bst20190238

Connecting species-specific extents of genome reduction in mitochondria and plastids

Autores: Konstantinos Giannakis, Luke Richards, Kazeem A. Dauda, Iain G. Johnston
Publicado en: Molecular Biology and Evolution, Edición 41, 2025, Página(s) msae097, ISSN 1537-1719
Editor: Oxford University Press
DOI: 10.1101/2023.12.14.571654

Sorting of mitochondrial and plastid heteroplasmy in Arabidopsis is extremely rapid and depends on MSH1 activity

Autores: AK Broz, A Keene, M Fernandes Gyorfy, M Hodous, IG Johnston, DB Sloan
Publicado en: PNAS, Edición 119, 2022, Página(s) e2206973119, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2206973119

Nucleoside supplements as treatments for mitochondrial DNA depletion syndrome

Autores: Eszter Dombi, Tony Marinaki, Paolo Spingardi, Val Millar, Nastasia Hadjichristou, Janet Carver, Iain G. Johnston, Carl Fratter, Joanna Poulton
Publicado en: Frontiers in Cell and Developmental Biology, Edición 12, 2024, ISSN 2296-634X
Editor: Frontiers Media SA
DOI: 10.3389/fcell.2024.1260496

Stromule geometry allows optimal spatial regulation of organelle interactions in the quasi-2D cytoplasm

Autores: Jessica Lee Erickson; Jennifer Prautsch; Frisine Reynvoet; Frederik Niemeyer; Gerd Hause; Iain G. Johnston; Martin Schattat
Publicado en: Plant and Cell Physiology, Edición pcad098, 2023, ISSN 0032-0781
Editor: Oxford University Press
DOI: 10.1101/2023.04.27.538610

2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA

Autores: Boris Pantic, Daniel Ives, Mara Mennuni, Diego Perez-Rodriguez, Uxoa Fernandez-Pelayo, Amaia Lopez de Arbina, Mikel Muñoz-Oreja, Marina Villar-Fernandez, Thanh-mai Julie Dang, Lodovica Vergani, Iain G. Johnston, Robert D. S. Pitceathly, Robert McFarland, Michael G. Hanna, Robert W. Taylor, Ian J. Holt & Antonella Spinazzola
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-26829-0

The cellular basis of feeding-dependent body size plasticity in sea anemones

Autores: Kathrin Garschall, Eudald Pascal-Carreras, Belén Garcia-Pascual, Daria Filimonova, Annika Guse, Iain G. Johnston, Patrick R.H Steinmetz
Publicado en: Development, Edición 151, 2025, Página(s) dev202926, ISSN 1477-9129
Editor: Company of Biologists
DOI: 10.1101/2023.05.15.540851

Altered collective mitochondrial dynamics in the Arabidopsis<i>msh1</i>mutant compromising organelle DNA maintenance

Autores: Joanna M Chustecki; Ross D Etherington; Daniel J Gibbs; Iain G Johnston
Publicado en: Journal of Experimental Botany, Edición 73, 2022, Página(s) 5428-5439, ISSN 0022-0957
Editor: Oxford University Press
DOI: 10.1093/jxb/erac250

Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics

Autores: Ana Victoria Lechuga-Vieco, Ana Latorre-Pellicer, Iain G. Johnston, Gennaro Prota, Uzi Gileadi, Raquel Justo-Méndez, Rebeca Acín-Pérez, Raquel Martínez-de-Mena, Jose María Fernández-Toro, Daniel Jimenez-Blasco, Alfonso Mora, Jose A. Nicolás-Ávila, Demetrio J. Santiago, Silvia G. Priori, Juan Pedro Bolaños, Guadalupe Sabio, Luis Miguel Criado, Jesús Ruíz-Cabello, Vincenzo Cerundolo, Nick
Publicado en: Science Advances, Edición 6/31, 2020, Página(s) eaba5345, ISSN 2375-2548
Editor: Science
DOI: 10.1126/sciadv.aba5345

HyperHMM: efficient inference of evolutionary and progressive dynamics on hypercubic transition graphs

Autores: Marcus T Moen, Iain G Johnston
Publicado en: Bioinformatics, Edición 39, 2023, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btac803

Network analysis of Arabidopsis mitochondrial dynamics reveals a resolved tradeoff between physical distribution and social connectivity

Autores: Joanna M.Chustecki, Daniel J.Gibbs, George W.Bassel, Iain G.Johnston
Publicado en: Cell Systems, 2021, ISSN 2405-4712
Editor: Cell Systems
DOI: 10.1016/j.cels.2021.04.006

Evolutionary accumulation modeling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance

Autores: Jessica Renz, Kazeem A. Dauda, Olav N. L. Aga, Ramon Diaz-Uriarte, Iren H. Löhr, Bjørn Blomberg, Iain G. Johnston
Publicado en: mBio, Edición 16, 2025, ISSN 2150-7511
Editor: American Society for Microbiology
DOI: 10.1128/mbio.00488-25

Organelle bottlenecks facilitate evolvability by traversing heteroplasmic fitness valleys

Autores: Arunas L. Radzvilavicius; Iain G. Johnston
Publicado en: Frontiers in Genetics, Edición 13, 2022, Página(s) 974472, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.1101/2021.01.28.428572

Varied Mechanisms and Models for the Varying Mitochondrial Bottleneck

Autores: Iain G. Johnston
Publicado en: Frontiers in Cell and Developmental Biology, Edición 7, 2019, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2019.00294

Efficient vasculature investment in tissues can be determined without global information.

Autores: Salva Duran-Nebreda; Iain G. Johnston; George W. Bassel
Publicado en: Journal of the Royal Society Interface, Edición 17, 2020, Página(s) 20200137, ISSN 1742-5689
Editor: The Royal Society
DOI: 10.1098/rsif.2020.0137

Other (1)

Paternal leakage of organelles can improve adaptation to changing environments

Autores: Arunas Radzvilavicius, Iain G. Johnston
Publicado en: 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.12.18.423500