Uncovering and engineering the principles governing evolution and cellular control of bioenergetic organelles

Resultado final

Publicaciones

Avoiding misleading estimates using mtDNA heteroplasmy statistics to study bottleneck size and selection

Autores: Konstantinos Giannakis; Amanda K. Broz; Daniel B. Sloan; Iain G. Johnston
Publicado en: G3, Edición 13, 2023, Página(s) jkad068, ISSN 2160-1836
Editor: Genetics Society of America
DOI: 10.1101/2022.09.06.506828

Intracellular Energy Variability Modulates Cellular Decision-Making Capacity

Autores: R Kerr, S Jabbari, IG Johnston
Publicado en: Scientific Reports, Edición 91, 2019, Página(s) p20196, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-56587-5

Evolutionary inference across eukaryotes identifies universal features shaping organelle gene retention

Autores: Konstantinos Giannakis, Samuel J. Arrowsmith, Luke Richards, Sara Gasparini, Joanna M. Chustecki, Ellen C. Røyrvik, Iain G. Johnston
Publicado en: Cell Systems, Edición 13, 2022, Página(s) 874-884, ISSN 2405-4712
Editor: Elsevier
DOI: 10.1016/j.cels.2022.08.007

Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck.

Autores: David M. Edwards; Ellen C. Røyrvik; Joanna M. Chustecki; Konstantinos Giannakis; Robert C. Glastad; Arunas L. Radzvilavicius; Iain G. Johnston
Publicado en: PLoS Biology, Vol 19, Iss 4, p e3001153 (2021), Edición 1, 2020, ISSN 1544-9173
Editor: Public Library of Science
DOI: 10.1371/journal.pbio.3001153

Efficient inference of evolutionary and progressive dynamics on hypercubic transition graphs

Autores: Marcus T. Moen; Iain G. Johnston
Publicado en: Bioinformatics, Edición 39, 2023, Página(s) btac803, ISSN 1367-4811
Editor: Oxford University Press
DOI: 10.1101/2022.05.09.491130

Stochastic organelle genome segregation through <i>Arabidopsis</i> development and reproduction

Autores: Amanda K. Broz; Daniel B. Sloan; Iain G. Johnston
Publicado en: New Phytologist, Edición 241, 2024, Página(s) 896-910, ISSN 0028-646X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/nph.19288

Cellular and environmental dynamics influence species-specific extents of organelle gene retention

Autores: Belén García Pascual; Jan M. Nordbotten; Iain G. Johnston
Publicado en: Proceedings of the Royal Society B, Edición 290, 2023, Página(s) 20222140, ISSN 0962-8452
Editor: Royal Society of London
DOI: 10.1101/2022.10.17.512581

Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions

Autores: Robert C. Glastad; Iain G. Johnston
Publicado en: PLoS Computational Biology, Edición 19, 2023, Página(s) e1010953, ISSN 1553-734X
Editor: Public Library of Science
DOI: 10.1101/2022.06.27.497759

Collective mitochondrial dynamics resolve conflicting cellular tensions: From plants to general principles

Autores: Joanna M Chustecki, Iain G Johnston
Publicado en: Seminars in Cell & Developmental Biology, Edición 156, 2024, Página(s) 253-265, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2023.09.005

Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease

Autores: Mona Synnøve Bjune Laurence Lawrence-Archer Johnny Laupsa-Borge Cathrine Horn Sommersten Adrian McCann Robert Clay Glastad Iain George Johnston Matthias Kern Matthias Blüher Gunnar Mellgren Simon N. Dankel
Publicado en: eBioMedicine, Edición 91, 2023, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104569

MtDNA sequence features associated with ‘selfish genomes’ predict tissue-specific segregation and reversion

Autores: Ellen C Røyrvik, Iain G Johnston
Publicado en: Nucleic Acids Research, Edición 48/15, 2020, Página(s) 8290-8301, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa622

Exchange on dynamic encounter networks allows plant mitochondria to collect complete sets of mitochondrial DNA products despite their incomplete genomes

Autores: Konstantinos Giannakis; Joanna M. Chustecki; Iain G. Johnston
Publicado en: Quantitative Plant Biology, Edición 3, 2022, Página(s) e18, ISSN 2632-8828
Editor: Cambridge University Press
DOI: 10.1017/qpb.2022.15

Mitochondrial Network State Scales mtDNA Genetic Dynamics

Autores: Juvid Aryaman, Charlotte Bowles, Nick S. Jones, Iain G. Johnston
Publicado en: Genetics, Edición 212/4, 2019, Página(s) 1429-1443, ISSN 0016-6731
Editor: Genetics Society of America
DOI: 10.1534/genetics.119.302423

Intracellular Energy Variability Modulates Cellular Decision-Making Capacity

Autores: Iain G. Johnston; Iain G. Johnston; Ryan Kerr; Sara Jabbari
Publicado en: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019), Edición 1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1101/2019.12.13.875427

Evolving mtDNA populations within cells

Autores: Iain G. Johnston, Joerg P. Burgstaller
Publicado en: Biochemical Society Transactions, Edición 47/5, 2019, Página(s) 1367-1382, ISSN 0300-5127
Editor: Portland Press, Ltd.
DOI: 10.1042/bst20190238

Sorting of mitochondrial and plastid heteroplasmy in Arabidopsis is extremely rapid and depends on MSH1 activity

Autores: AK Broz, A Keene, M Fernandes Gyorfy, M Hodous, IG Johnston, DB Sloan
Publicado en: PNAS, Edición 119, 2022, Página(s) e2206973119, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2206973119

Stromule geometry allows optimal spatial regulation of organelle interactions in the quasi-2D cytoplasm

Autores: Jessica Lee Erickson; Jennifer Prautsch; Frisine Reynvoet; Frederik Niemeyer; Gerd Hause; Iain G. Johnston; Martin Schattat
Publicado en: Plant and Cell Physiology, Edición pcad098, 2023, ISSN 0032-0781
Editor: Oxford University Press
DOI: 10.1101/2023.04.27.538610

2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA

Autores: Boris Pantic, Daniel Ives, Mara Mennuni, Diego Perez-Rodriguez, Uxoa Fernandez-Pelayo, Amaia Lopez de Arbina, Mikel Muñoz-Oreja, Marina Villar-Fernandez, Thanh-mai Julie Dang, Lodovica Vergani, Iain G. Johnston, Robert D. S. Pitceathly, Robert McFarland, Michael G. Hanna, Robert W. Taylor, Ian J. Holt & Antonella Spinazzola
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-26829-0

Altered collective mitochondrial dynamics in the Arabidopsis<i>msh1</i>mutant compromising organelle DNA maintenance

Autores: Joanna M Chustecki; Ross D Etherington; Daniel J Gibbs; Iain G Johnston
Publicado en: Journal of Experimental Botany, Edición 73, 2022, Página(s) 5428-5439, ISSN 0022-0957
Editor: Oxford University Press
DOI: 10.1093/jxb/erac250

Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics

Autores: Ana Victoria Lechuga-Vieco, Ana Latorre-Pellicer, Iain G. Johnston, Gennaro Prota, Uzi Gileadi, Raquel Justo-Méndez, Rebeca Acín-Pérez, Raquel Martínez-de-Mena, Jose María Fernández-Toro, Daniel Jimenez-Blasco, Alfonso Mora, Jose A. Nicolás-Ávila, Demetrio J. Santiago, Silvia G. Priori, Juan Pedro Bolaños, Guadalupe Sabio, Luis Miguel Criado, Jesús Ruíz-Cabello, Vincenzo Cerundolo, Nick
Publicado en: Science Advances, Edición 6/31, 2020, Página(s) eaba5345, ISSN 2375-2548
Editor: Science
DOI: 10.1126/sciadv.aba5345

Network analysis of Arabidopsis mitochondrial dynamics reveals a resolved tradeoff between physical distribution and social connectivity

Autores: Joanna M.Chustecki, Daniel J.Gibbs, George W.Bassel, Iain G.Johnston
Publicado en: Cell Systems, 2021, ISSN 2405-4712
Editor: Cell Systems
DOI: 10.1016/j.cels.2021.04.006

Organelle bottlenecks facilitate evolvability by traversing heteroplasmic fitness valleys

Autores: Arunas L. Radzvilavicius; Iain G. Johnston
Publicado en: Frontiers in Genetics, Edición 13, 2022, Página(s) 974472, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.1101/2021.01.28.428572

Varied Mechanisms and Models for the Varying Mitochondrial Bottleneck

Autores: Iain G. Johnston
Publicado en: Frontiers in Cell and Developmental Biology, Edición 7, 2019, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2019.00294

Efficient vasculature investment in tissues can be determined without global information.

Autores: Salva Duran-Nebreda; Iain G. Johnston; George W. Bassel
Publicado en: Journal of the Royal Society Interface, Edición 17, 2020, Página(s) 20200137, ISSN 1742-5689
Editor: The Royal Society
DOI: 10.1098/rsif.2020.0137

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