Localised chronic inflammation could shed light on shared mechanisms across many diseases
Chronic inflammation plays a role in numerous diseases and conditions, among them cancer, heart diseases, diabetes and rheumatoid arthritis. The processes underlying it are closely related to immune system function. Granulomatous diseases are also chronic inflammatory diseases. Although less well known, they affect millions, often young people. In these diseases, macrophages of the immune system run amok, leading to areas of organised inflammation called granulomas. It is known that macrophage precursors trigger the body's DNA damage response (DDR), leading to pathological changes in macrophages. The EU-funded DDRMac project is investigating the possibility that these changes are responsible for granuloma formation. Given the interlinked roles of inflammation, DDR, immune system dysfunction, and numerous diseases and conditions, the outcomes could have far-reaching therapeutic implications.
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