Targeted microbubble vibrations to accurately diagnose and treat cardiac device-related bacterial biofilm infections

Project Information

BUBBLE CURE

Grant agreement ID: 805308

DOI

10.3030/805308

Project closed

EC signature date 5 November 2018

Start date 1 January 2019

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 878 000,00

EU contribution

€ 1 878 000,00

Coordinated by

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Early Fibrin Biofilm Development in Cardiovascular Infections

Author(s): Safae Oukrich, Jane Hong, Mariël Leon-Grooters, Wiggert van Cappellen, Johan A. Slotman, Gijsje H. Koenderink, Willem J.B. van Wamel, Moniek P.M. de Maat, Klazina Kooiman, Kirby R. Lattwein
Published in: Biofilm, 2026, ISSN 2590-2075
Publisher: Elsevier
DOI: 10.1101/2024.09.02.610803

Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies

Author(s): Joop J. P. Kouijzer; Daniëlle J. Noordermeer; Wouter J. van Leeuwen; Nelianne J. Verkaik; Kirby R. Lattwein
Published in: Frontiers in Cell and Developmental Biology, Issue 10 - 2022, 2022, Page(s) 10:995508, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2022.995508

Vancomycin-decorated microbubbles as a theranostic agent for Staphylococcus aureus biofilms

Author(s): Joop J.P. Kouijzer, Kirby R. Lattwein, Inés Beekers, Simone A.G. Langeveld, Mariël Leon-Grooters, Jean-Marc Strub, Estefania Oliva, Gaëtan L.A. Mislin, Nico de Jong, Antonius F.W. van der Steen, Alexander L. Klibanov, Willem J.B. van Wamel, Klazina Kooiman
Published in: International Journal of Pharmaceutics, Issue 609, 2021, Page(s) 121154, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.121154

Production of Stable Monodisperse Phospholipid-coated Microbubbles at Room Temperature Using a Microfluidic Flow-focusing Device

Author(s): Yuchen Wang, Benjamin R. G. Johnson, Klazina Kooiman
Published in: Journal of Visualized Experiments, 2025, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/68796

Dispersing and Sonoporating Biofilm-Associated Bacteria with Sonobactericide

Author(s): Kirby R. Lattwein; Inés Beekers; Joop J. P. Kouijzer; Mariël Leon-Grooters; Simone A. G. Langeveld; Tom van Rooij; Antonius F. W. van der Steen; Nico de Jong; Willem J. B. van Wamel; Klazina Kooiman
Published in: Pharmaceutics, Issue 14, 2022, Page(s) 1164, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14061164

Shape oscillation and 3-D microstreaming profile of a phospholipid-coated microbubble attached to a wall

Author(s): Hongchen Li, Yuchen Wang, Ruisheng Su, Christian Cierpka, Michel Versluis, Antonius F. W. Van Der Steen, Nico De Jong, Martin D. Verweij, Klazina Kooiman
Published in: IEEE Transactions on Ultrasonics, 2026, Page(s) 1-1, ISSN 3066-9464
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/tuson.2026.3676695

Coupling Two Ultra-high-Speed Cameras to Elucidate Ultrasound Contrast-Mediated Imaging and Therapy

Author(s): Hongchen Li, Xiufeng Li, Gonzalo Collado-Lara, Kirby R. Lattwein, Frits Mastik, Robert Beurskens, Antonius F.W. van der Steen, Martin D. Verweij, Nico de Jong, Klazina Kooiman
Published in: Ultrasound in Medicine & Biology, Issue 49, 2025, Page(s) 388-397, ISSN 0301-5629
Publisher: Elsevier BV
DOI: 10.1016/j.ultrasmedbio.2022.08.020

Influence of Pluronic F68 on size stability and acoustic behavior of monodisperse phospholipid-coated microbubbles produced at room temperature

Author(s): Yuchen Wang, Sander Spiekhout, Ana Walgode, Gonzalo Collado-Lara, Antonius van der Steen, Nico de Jong, Johannes Bosch, Benjamin Johnson, Klazina Kooiman
Published in: ACS Applied Materials & Interfaces, 2026, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.26434/chemrxiv-2024-z79r9

Nondestructive Ultrasound Molecular Imaging With Higher Order Singular Value Decomposition

Author(s): Gonzalo Collado-Lara, Geraldi Wahyulaksana, Hendrik J. Vos, Klazina Kooiman
Published in: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Issue 72, 2025, Page(s) 1095-1107, ISSN 0885-3010
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tuffc.2025.3578895

Ultrasonic Characterization of Ibidi <i>μ</i>-Slide I Luer Channel Slides for Studies With Ultrasound Contrast Agents

Author(s): Reza Pakdaman Zangabad; Hongchen Li; Joop J. P. Kouijzer; Simone A. G. Langeveld; Inés Beekers; Martin Verweij; Nico De Jong; Klazina Kooiman
Published in: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Issue 70, 2023, Page(s) 422 - 429, ISSN 0885-3010
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tuffc.2023.3250202

Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery

Author(s): Klazina Kooiman, Silke Roovers, Simone A.G. Langeveld, Robert T. Kleven, Heleen Dewitte, Meaghan A. O'Reilly, Jean-Michel Escoffre, Ayache Bouakaz, Martin D. Verweij, Kullervo Hynynen, Ine Lentacker, Eleanor Stride, Christy K. Holland
Published in: Ultrasound in Medicine & Biology, Issue 46/6, 2020, Page(s) 1296-1325, ISSN 0301-5629
Publisher: Elsevier BV
DOI: 10.1016/j.ultrasmedbio.2020.01.002

Dependence of endothelial drug delivery on monodisperse microbubble dynamics

Author(s): Yuchen Wang, Hongchen Li, Bram Meijlink, Robert Beurskens, Benjamin R.G. Johnson, Klazina Kooiman
Published in: Journal of Controlled Release, Issue 384, 2026, Page(s) 113867, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2025.113867

Non-peer reviewed articles (3)

Microbubble-mediated adjunct treatment for cardiovascular bacterial infections

Author(s): Kirby R. Lattwein, Margot E. Starrenburg, Joop J. Kouijzer, Mariël Leon-Grooters, Moniek P. de Maat, Willem J. van Wamel, Klazina Kooiman
Published in: The Journal of the Acoustical Society of America, Issue 151, 2023, Page(s) A154-A154, ISSN 0001-4966
Publisher: Acoustical Society of America
DOI: 10.1121/10.0010948

Microstreaming profile of a phospholipid-coated wall-attached microbubble undergoing shape oscillation

Author(s): Hongchen Li, Yuchen Wang, Ruisheng Su, Christian Cierpka, Michel Versluis, Antonius F. van der Steen, Martin D. Verweij, Nico de Jong, Klazina Kooiman
Published in: The Journal of the Acoustical Society of America, Issue 155, 2024, Page(s) A135-A135, ISSN 0001-4966
Publisher: Acoustical Society of America
DOI: 10.1121/10.0027070

Monodisperse microbubble-mediated drug delivery: Influence of microbubbles size on drug delivery outcome

Author(s): Yuchen Wang, Hongchen Li, Bram Meijlink, Jiali Luo, Robert Beurskens, Benjamin Johnson, Klazina Kooiman
Published in: The Journal of the Acoustical Society of America, Issue 155, 2024, Page(s) A325-A325, ISSN 0001-4966
Publisher: Acoustical Society of America
DOI: 10.1121/10.0027679

Thesis and dissertations (3)

Microbubble Oscillations and Microstreaming for Local Drug Delivery (PhD thesis)

Author(s): Hongchen Li
Published in: 2026, ISBN 9789465343594
Publisher: ProefschriftMaken

Early pathophysiology of Staphylococcus aureus fibrin biofilms (Master graduation thesis)

Author(s): Safae Oukrich
Published in: 2023
Publisher: VUmc School of Medical Sciences

Theranostic microbubbles for cardiovascular infections (PhD thesis)

Author(s): Joop Kouijzer
Published in: 2023, ISBN 9789464732504
Publisher: Ipskamp Printing