Remote Assessment of Disease and Relapse – Alzheimer’s Disease

Información del proyecto

RADAR-AD

Identificador del acuerdo de subvención: 806999

DOI

10.3030/806999

Proyecto cerrado

Fecha de la firma de la CE 5 Diciembre 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 30 Junio 2023

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 7 659 120,00

Aportación de la UE

€ 4 999 757,00

Coordinado por

KING'S COLLEGE LONDON
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (10)

Dissemination of platform work as documented, deployable, open source components on RADAR-base
First meeting standing patient advisory group
Integration of additional data sources and report detailing setup and on-boarding process for each device integrated with the platform
Second meeting standing patient advisory group
Third meeting standing patient advisory group
Customized platform and test plan for WP5 study
Pre-study-start release of deployable Plug-in components
Organize an international conference/symposium
Full implementation of communication strategy
Post-study-start release of deployable plug-in components

Websites, patent fillings, videos etc. (2)

Launch of website
Generic press release to be used by all partners

Documents, reports (20)

Device Selection Report for Tiers 1, 2 & 3 of the WP5 study: Presents the device selection process, criteria and outcomes with the final choice of devices for pilots of all tiers
Final report PAB activities
Briefing package for stakeholders
Generation of the overview on the variables, cohort selection and intermediate statistical modeling
Preliminary Prioritized list of functional domains
First update of Data Management Plan
Focus group report on ADLs that can be monitored with RMT
Confirmed Prioritized list of functional domains for use in WP5
Focus group report on AD patients as vulnerable population, stigma and misuse of RMT
Report on Kick-Off meeting
Draft version of Data Management Plan
Identification and evaluation of Longitudinal Cohorts
Report on insights from patient and caregiver interviews on moral beliefs
Final version of Data Management Plan
Research protocol
Develop visual identity and communication strategy
First meeting report of the standing regulatory and policy advisory group
Report with assessment of regulatory situation
Updated version of research protocol
Manuscript describing functional domains

Demonstrators, pilots, prototypes (1)

Installed and tested live RADAR-AD environment for use by WP5

Publicaciones

Conference proceedings (11)

Human factors, device selection and application development for the RADAR-AD Study on digital biomarkers for Alzheimer’s Disease

Autores: Thanos G. Stavropoulos, Ioulietta Lazarou, Lampros Mpaltadoros, Spiros Nikolopoulos, Ioannis Kompatsiaris, Magda Tsolaki and the RADAR-AD Consortium
Publicado en: 12th Panhellenic Conference of Alzheimer’s Disease and 4th Mediterranean Conference on Neurodegenerative Diseases, PICAD & MeCoND, 2021, Página(s) -
Editor: -

Digital Biomarkers for Alzheimer’s Disease in a Real-Living Smart Home Environment: the RADAR-AD Tier 3 Study

Autores: T. G. Stravropoulos, I. Lazarou, V. Alepopoulos, L. Mpaltadoros, M. Grammatikopoulou, M. Muurling, C. Hinds, S. Nikolopoulos, P. J. Visser, M. Tsolaki, I. Kompatsiaris and the RADAR-AD Consortium
Publicado en: 2021
Editor: Alzheimer Europe Conference 2021

Wearable Device System for Assisted Living of Elders - 8th Panhellenic Conference on Biomedical Technology

Autores: T. G. Stavropoulos, D. Strantsalis, O. Pronakis, S. Nikolopoulos and I. Kompatsiaris (2019).
Publicado en: 8th Pnahellenic Conference on Biomedical Engineering, Edición 9-10 May 2019, 2019, Página(s) 32, ISBN 978-960-243-714-8
Editor: ELEVIT

App-based augmented reality to assess cognitive impairment in early Alzheimer’s disease

Autores: Anna-Katharine Brem et al
Publicado en: AAIC Conference, Amsterdam July 2023, 2023
Editor: NA

Investigating the impact of a real domestic smart home environment in people with cognitive impairment as part of the RADAR-AD Tier 3 Study: A Usability study

Autores: Ioulietta Lazarou, Margarita Grammatikopoulou, Lampros Mpaltadoros, Vasillis Alepopoulos, Spiros Nikolopoulos, Thanos G Stravropoulos, Casper de Boer, Pieter Jelle Visser, Magda Tsolaki, Ioannis Kompatsiaris, Dag Aarsland, Vaibhav A Narayan, the RADAR-AD Consortium
Publicado en: 2022
Editor: 32nd Alzheimer Europe Conference 2022

Evaluating Digital Device Technology in Alzheimer’s Disease via Artificial Intelligence

Autores: Meemansa Sood, Martin Hofmann-Apitius, Holger Fröhlich
Publicado en: Conference abstract to the 2021 Alzheimer's Association International Conference, 2021
Editor: -

Motor-cognitive dual tasking in the clinical setting: a sensitive measure of functional impairment in early Alzheimer’s disease

Autores: Anna-Katharine Brem et al
Publicado en: AAIC Conference, Amsterdam July 2023, 2023
Editor: NA

Remote assessment of functional impairment in Alzheimer's disease: results of the RADAR-AD study; A multimodal digital biomarker of functional deficits in early-stage Alzheimer's disease: results of the RADAR-AD study; Motor-cognitive dual tasking in the clinical setting: a sensitive measure of functional impairment in early Alzheimer’s disease; First insights exploring Activities of Daily Livin

Autores: Marijn Muurling, MSc1,2, Casper de Boer, PhD1,2, Srinivasan Vairavan, PhD3, Jelena Curcic, PhD4, Gaetano Scebba, PhD4, Alankar Atreya5, Chris Hinds, PhD5, Pauline Conde6, Margarita Grammatikopoulou, MSc7, Ioulietta Lazarou, PhD7, Spiros Nikolopoulos, PhD7, Katy Brem, PhD8, Neva Coello, M.Sc4, Vaibhav A Narayan, PhD9, Gayle Wittenberg, PhD3, Dag Aarsland, MD, PhD6,10, Pieter Jelle Visser, MD, PhD1,
Publicado en: AAIC 2023, 2023
Editor: NA

Investigating Brain Response of People with CognitiveImpairment during Meditation with wireless Muse EEGin a Smart-Home Setting

Autores: I. Lazarou, V. Oikonomou, L. Mpaltadoros, M. Grammatikopoulou, V. Alepopoulos, S. Nikolopoulos, T.G. Stavropoulos, I. Kompatsiaris, M. Tsolaki and the RADAR-AD Consortium
Publicado en: 13th PICAD and 5th MeCoND, 2023
Editor: NA

An app to measure functional decline in managing finances in Alzheimer’s disease: preliminary results of the RADAR-AD study

Autores: Thanos G. Stavropoulos, Ioulietta Lazarou, Spiros Nikolopoulos, Ioannis Kompatsiaris, Magda Tsolaki.
Publicado en: Alzheimer's Association International Conference (AAIC) 2021, 2021, Página(s) -
Editor: -

Assessment of functional performance across the Alzheimer spectrum using remote monitoring technologies: design and feasibility results of the RADAR-AD study; Observer-reported outcome of functional decline: moving towards an experience sampling method to capture decline in everyday cognitive activities: findings from the RADAR-AD study; Augmented reality to remotely assess cognition in early Alzh

Autores: Marijn Muurling1,2, Casper de Boer1,2*, Srinivasan Vairavan3, Robbert L Harms4, Antonella Santuccione Chadha4, Ioannis Tarnanas4,5, Estefania Vilarino Luis6, Lucrezia Hausner7, Mara Gkioka8, Dorota Religa9, Martha Therese Gjestsen10,11, Samantha Galluzzi12, Marta Ibarria Sala13, Ivan Koychev14, Dag Aarsland10,15, Pieter Jelle Visser1,2,9,16, Anna-Katharine Brem15,17, and the RADAR-AD consortium18
Publicado en: CTAD 2023, 2023
Editor: NA

Peer reviewed articles (12)

IoT Wearable Sensors and Devices in Elderly Care: A Literature Review

Autores: Thanos G. Stavropoulos, Asterios Papastergiou, Lampros Mpaltadoros, Spiros Nikolopoulos, Ioannis Kompatsiaris
Publicado en: Sensors, Edición 20/10, 2020, Página(s) 2826, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20102826

Eliciting brain waves of people with cognitive impairment during meditation exercises using portable electroencephalography in a smart-home environment: a pilot study

Autores: I. Lazarou, V. Oikonomou, L. Mpaltadoros, M. Grammatikopoulou, V. Alepopoulos, T.G. Stavropoulos, A. Bezerianos, S. Nikolopoulos, I. Kompatsiaris, M. Tsolaki and the RADAR-AD Consortium
Publicado en: Frontiers in Aging Neuroscience, 2023, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2023.1167410

Robust Motor Imagery Classification Using Sparse Representations and Grouping Structures

Autores: Vangelis P. Oikonomou, Spiros Nikolopoulos, Ioannis Kompatsiaris
Publicado en: IEEE Access, Edición 8, 2020, Página(s) 98572-98583, ISSN 2169-3536
Editor: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2020.2997116

Digital endpoints in clinical trials of Alzheimer’s disease and other neurodegenerative diseases: challenges and opportunitie

Autores: Anna-Katharine Brem1,2*, Sajini Kuruppu1, Casper de Boer3,4, Marijn Muurling3,4, Ana Diaz-Ponce5, Dianne Gove5, Jelena Curcic6, Andrea Pilotto7,8,9, Wan-Fai Ng10,11, Nicholas Cummins12, Kristina Malzbender13, Vera J. M. Nies14, Gul Erdemli15, Johanna Graeber16, Vaibhav A. Narayan17, Lynn Rochester18,19, Walter Maetzler20 and Dag Aarsland1,21 on behalf of the RADAR-AD Consortium
Publicado en: Front. Neurol., 2023, ISSN 1664-2295
Editor: Frontiers Research Foundation

Remote monitoring technologies in Alzheimer’s disease: design of the RADAR-AD study

Autores: Marijn Muurling, Casper de Boer, Rouba Kozak, Dorota Religa, Ivan Koychev, Herman Verheij, Vera J. M. Nies, Alexander Duyndam, Meemansa Sood, Holger Fröhlich, Kristin Hannesdottir, Gul Erdemli, Federica Lucivero, Claire Lancaster, Chris Hinds, Thanos G. Stravopoulos, Spiros Nikolopoulos, Ioannis Kompatsiaris, Nikolay V. Manyakov, Andrew P. Owens, Vaibhav A. Narayan, Dag Aarsland, Pieter Jelle Vis
Publicado en: Alzheimer's Research & Therapy, Edición 13/1, 2021, ISSN 1758-9193
Editor: BioMed Central
DOI: 10.1186/s13195-021-00825-4

The Role of Heart Rate Variability in the Future of Remote Digital Biomarkers

Autores: Andrew P. Owens
Publicado en: Frontiers in Neuroscience, Edición 14, 2020, Página(s) 1202, ISSN 1662-453X
Editor: Frontiers
DOI: 10.3389/fnins.2020.582145

Ethical challenges of using remote monitoring technologies for clinical research: A case studyof the role of local research ethics committees in the RADAR-AD study

Autores: Marijn Muurling 1 2, Anna M G Pasmooij 3, Ivan Koychev 4, Dora Roik 5, Lutz Froelich 5, Emilia Schwertner 6 7, Dorota Religa 6 8, Carla Abdelnour 9, Mercè Boada 10 11, Monica Almici 12, Samantha Galluzzi 12, Sandra Cardoso 13, Alexandre de Mendonça 13, Andrew P Owens 14, Sajini Kuruppu 14, Martha Therese Gjestsen 15, Ioulietta Lazarou 16, Mara Gkioka 17, Magda Tsolaki 17, Ana Diaz 18, Dianne Gov
Publicado en: plos one, 2023, ISSN 1932-6203
Editor: Public Library of Science

Selecting Remote Measurement Technologies to Optimize Assessment of Function in Early Alzheimer's Disease: A Case Study

Autores: Andrew P. Owens, Chris Hinds, Nikolay V. Manyakov, Thanos G. Stavropoulos, Grace Lavelle, Dianne Gove, Ana Diaz-Ponce, Dag Aarsland
Publicado en: Frontiers in Psychiatry, Edición 11, 2020, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.582207

Wearable Devices for Assessing Function in Alzheimer's Disease: A European Public Involvement Activity About the Features and Preferences of Patients and Caregivers

Autores: Thanos G. Stavropoulos, Ioulietta Lazarou, Ana Diaz, Dianne Gove, Jean Georges, Nikolay V. Manyakov, Emilio Merlo Pich, Chris Hinds, Magda Tsolaki, Spiros Nikolopoulos, Ioannis Kompatsiaris
Publicado en: Frontiers in Aging Neuroscience, Edición 13, 2021, Página(s) 149, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2021.643135

Exploring Network Properties Across Preclinical Stages of Alzheimer's Disease Using a Visual Short-Term Memory and Attention Task with High-Density Electroencephalography: A Brain-Connectome Neurophysiological Study

Autores: Ioulietta Lazarou, Kostas Georgiadis, Spiros Nikolopoulos, Vangelis P Oikonomou, Thanos G Stavropoulos, Anthoula Tsolaki, Ioannis Kompatsiaris, Magda Tsolaki, RADAR-AD Consortium
Publicado en: Journal of Alzheimer's Disease, Edición 13872877, 2022, Página(s) 643-664, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-215421

Sensors in Everyday Objects for Dementia Care

Autores: Stavropoulos, T. G., Nikolopoulos, S., & Kompatsiaris, I.
Publicado en: HealthManagement, Edición Volume 19 - Edición 4, 2019, 2019, Página(s) 323-325, ISSN 1377-7629
Editor: HealthManagement

The Use of Remote Monitoring Technologies: A Review of Recent Regulatory Scientific Advices, Qualification Opinions, and Qualification Advices Issued by the European Medicines Agency

Autores: Marieke J. H. J. Dekker, Pieter Stolk, Anna M. G. Pasmooij
Publicado en: Frontiers in Medicine, Edición 8, 2021, Página(s) -, ISSN 2296-858X
Editor: Frontiers
DOI: 10.3389/fmed.2021.619513