Defining the role of Arp2/3 complex diversity at multiple scales of biology

Project Information

ArpComplexity

Grant agreement ID: 810207

DOI

10.3030/810207

EC signature date 14 January 2019

Start date 1 July 2019

End date 30 June 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 10 715 153,00

EU contribution

€ 10 715 153,00

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

Author(s): Tianyang Liu, Luyan Cao, Miroslav Mladenov, Antoine Jegou, Michael Way and Carolyn A. Moores
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.08.16.553490

The role of the cell nucleus in mechanotransduction

Author(s): Cátia S. Janota, Francisco Javier Calero-Cuenca, Edgar R. Gomes
Published in: Current Opinion in Cell Biology, Issue 63, 2020, Page(s) 204-211, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2020.03.001

Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration

Author(s): Francisco J. Calero-Cuenca, Daniel S. Osorio, Sofia Carvalho-Marques, Sreerama Chaitanya Sridhara, Luis M. Oliveira, Yue Jiao, Jheimmy Diaz, Cátia S. Janota, Bruno Cadot, Edgar R. Gomes
Published in: Current Biology, Issue 31/7, 2021, Page(s) 1521-1530.e8, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.01.007

MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

Author(s): Chiara Galloni, Davide Carra, Jasmine V.G. Abella, Svend Kjær, Pavithra Singaravelu, David J. Barry, Naoko Kogata, Christophe Guérin, Laurent Blanchoin, Michael Way
Published in: Journal of Cell Biology, Issue 220/8, 2021, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202102043

Generating fast-twitch myotubes in vitro with an optogenetic-based, quantitative contractility assay

Author(s): Hennig, K., Hardman, D., Barata, D.M., Martins, I.I., Bernabeu, M.O., Gomes, E.R., and Roman, W.
Published in: Life Science Alliance, 2023, ISSN 2575-1077
Publisher: Elsevier Inc.
DOI: 10.26508/lsa.202302227

Biomimetic actin cortices shape cell-sized lipid vesicles.

Author(s): Lucia Baldauf, Felix Frey, Marcos Arribas Perez, Miroslav Mladenov, Michael Way, Timon Idema, and Gijsje H Koenderink
Published in: BioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.01.15.524117

Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction

Author(s): William Roman, Helena Pinheiro, Mafalda R Pimentel, Jessica Segalés, Luis M Oliveira, Esther García-Domínguez, Mari Carmen Gómez-Cabrera, Antonio L Serrano, Edgar R Gomes, Pura Muñoz-Cánoves
Published in: science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abe5620

Nucleation and stability of branched versus linear Arp2/3-generated actin filaments

Author(s): Luyan Cao, Foad Ghasemi, Michael Way, Antoine Jégou and Guillaume Romet-Lemonne
Published in: The EMBO Journal, 2023, ISSN 1460-2075
Publisher: EMBO Press
DOI: 10.15252/embj.2022113008

Shielding of actin by the endoplasmic reticulum impacts nuclear positioning

Author(s): Cátia S. Janota, Andreia Pinto, Anna Pezzarossa,Pedro Machado, Judite Costa, Pedro Campinho, Cláudio A. Franco, Edgar R. Gomes
Published in: Nature communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30388-3

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

Author(s): Ottilie von Loeffelholz, Andrew Purkiss, Luyan Cao, Svend Kjaer, Naoko Kogata, Guillaume Romet-Lemonne, Michael Way, Carolyn A. Moores
Published in: Biology Open, Issue 9/7, 2020, Page(s) bio054304, ISSN 2046-6390
Publisher: Biology Open
DOI: 10.1242/bio.054304

mRNA distribution in skeletal muscle is associated with mRNA size.

Author(s): Helena Pinheiro, Mafalda Ramos Pimentel, Catarina Sequeira, Luis M Oliveira, Anna Pezzarossa, William Roman, Edgar R Gomes
Published in: Journal of Cell Science, 2021, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.256388

ARPC5 Isoforms and Their Regulation by Calcium-Calmodulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells

Author(s): Lopamudra Sadhu, Nikolaos Tsopoulidis, Md Hasanuzzaman, Vibor Laketa, Michael Way and Oliver T. Fackler
Published in: eLife, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.82450

ARPC5 deficiency leads to severe early onset systemic inflammation and mortality

Author(s): Elena Sindram, Andrés Caballero-Oteyza, Naoko Kogata, Shaina Huang, Zahra Alizadeh, Laura Gamez, Mohammad Reza Fazlollhi, Xiao Peng, Bodo Grimbacher, Michael Way and Michele Proietti
Published in: Disease Models & Mechanisms, 2023, ISSN 2046-6390
Publisher: The Company of Biologists
DOI: 10.1242/dmm.050145

Drosophila motor neuron boutons remodel through membrane blebbing coupled with muscle contraction

Author(s): Fernandes, A.R., Martins, J.P., Gomes, E.R., Mendes, C.S., and Teodoro, R.O.
Published in: Nature communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38421-9

Regeneration of actin filament branches from the same Arp2/3 complex

Author(s): Foad Ghasemi, LuYan Cao, Miroslav Mladenov, Bérengère Guichard, Michael Way, Antoine Jégou*, and Guillaume Romet-Lemonne
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.09.22.558980