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Defining the role of Arp2/3 complex diversity at multiple scales of biology


Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

Author(s): Tianyang Liu, Luyan Cao, Miroslav Mladenov, Antoine Jegou, Michael Way and Carolyn A. Moores
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.08.16.553490

The role of the cell nucleus in mechanotransduction

Author(s): Cátia S. Janota, Francisco Javier Calero-Cuenca, Edgar R. Gomes
Published in: Current Opinion in Cell Biology, Issue 63, 2020, Page(s) 204-211, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/

Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration

Author(s): Francisco J. Calero-Cuenca, Daniel S. Osorio, Sofia Carvalho-Marques, Sreerama Chaitanya Sridhara, Luis M. Oliveira, Yue Jiao, Jheimmy Diaz, Cátia S. Janota, Bruno Cadot, Edgar R. Gomes
Published in: Current Biology, Issue 31/7, 2021, Page(s) 1521-1530.e8, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2021.01.007

MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

Author(s): Chiara Galloni, Davide Carra, Jasmine V.G. Abella, Svend Kjær, Pavithra Singaravelu, David J. Barry, Naoko Kogata, Christophe Guérin, Laurent Blanchoin, Michael Way
Published in: Journal of Cell Biology, Issue 220/8, 2021, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202102043

Generating fast-twitch myotubes in vitro with an optogenetic-based, quantitative contractility assay

Author(s): Hennig, K., Hardman, D., Barata, D.M., Martins, I.I., Bernabeu, M.O., Gomes, E.R., and Roman, W.
Published in: Life Science Alliance, 2023, ISSN 2575-1077
Publisher: Elsevier Inc.
DOI: 10.26508/lsa.202302227

Biomimetic actin cortices shape cell-sized lipid vesicles.

Author(s): Lucia Baldauf, Felix Frey, Marcos Arribas Perez, Miroslav Mladenov, Michael Way, Timon Idema, and Gijsje H Koenderink
Published in: BioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.01.15.524117

Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction

Author(s): William Roman, Helena Pinheiro, Mafalda R Pimentel, Jessica Segalés, Luis M Oliveira, Esther García-Domínguez, Mari Carmen Gómez-Cabrera, Antonio L Serrano, Edgar R Gomes, Pura Muñoz-Cánoves
Published in: science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abe5620

Nucleation and stability of branched versus linear Arp2/3-generated actin filaments

Author(s): Luyan Cao, Foad Ghasemi, Michael Way, Antoine Jégou and Guillaume Romet-Lemonne
Published in: The EMBO Journal, 2023, ISSN 1460-2075
Publisher: EMBO Press
DOI: 10.15252/embj.2022113008

Shielding of actin by the endoplasmic reticulum impacts nuclear positioning

Author(s): Cátia S. Janota, Andreia Pinto, Anna Pezzarossa,Pedro Machado, Judite Costa, Pedro Campinho, Cláudio A. Franco, Edgar R. Gomes
Published in: Nature communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30388-3

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

Author(s): Ottilie von Loeffelholz, Andrew Purkiss, Luyan Cao, Svend Kjaer, Naoko Kogata, Guillaume Romet-Lemonne, Michael Way, Carolyn A. Moores
Published in: Biology Open, Issue 9/7, 2020, Page(s) bio054304, ISSN 2046-6390
Publisher: Biology Open
DOI: 10.1242/bio.054304

mRNA distribution in skeletal muscle is associated with mRNA size.

Author(s): Helena Pinheiro, Mafalda Ramos Pimentel, Catarina Sequeira, Luis M Oliveira, Anna Pezzarossa, William Roman, Edgar R Gomes
Published in: Journal of Cell Science, 2021, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.256388

ARPC5 Isoforms and Their Regulation by Calcium-Calmodulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells

Author(s): Lopamudra Sadhu, Nikolaos Tsopoulidis, Md Hasanuzzaman, Vibor Laketa, Michael Way and Oliver T. Fackler
Published in: eLife, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.82450

ARPC5 deficiency leads to severe early onset systemic inflammation and mortality

Author(s): Elena Sindram, Andrés Caballero-Oteyza, Naoko Kogata, Shaina Huang, Zahra Alizadeh, Laura Gamez, Mohammad Reza Fazlollhi, Xiao Peng, Bodo Grimbacher, Michael Way and Michele Proietti
Published in: Disease Models & Mechanisms, 2023, ISSN 2046-6390
Publisher: The Company of Biologists
DOI: 10.1242/dmm.050145

Drosophila motor neuron boutons remodel through membrane blebbing coupled with muscle contraction

Author(s): Fernandes, A.R., Martins, J.P., Gomes, E.R., Mendes, C.S., and Teodoro, R.O.
Published in: Nature communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38421-9

Regeneration of actin filament branches from the same Arp2/3 complex

Author(s): Foad Ghasemi, LuYan Cao, Miroslav Mladenov, Bérengère Guichard, Michael Way, Antoine Jégou*, and Guillaume Romet-Lemonne
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.09.22.558980

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