Defining the role of Arp2/3 complex diversity at multiple scales of biology

Información del proyecto

ArpComplexity

Identificador del acuerdo de subvención: 810207

DOI

10.3030/810207

Fecha de la firma de la CE 14 Enero 2019

Fecha de inicio 1 Julio 2019

Fecha de finalización 30 Junio 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 10 715 153,00

Aportación de la UE

€ 10 715 153,00

Coordinado por

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (15)

Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

Autores: Tianyang Liu, Luyan Cao, Miroslav Mladenov, Antoine Jegou, Michael Way and Carolyn A. Moores
Publicado en: bioRxiv, 2023, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.08.16.553490

The role of the cell nucleus in mechanotransduction

Autores: Cátia S. Janota, Francisco Javier Calero-Cuenca, Edgar R. Gomes
Publicado en: Current Opinion in Cell Biology, Edición 63, 2020, Página(s) 204-211, ISSN 0955-0674
Editor: Elsevier BV
DOI: 10.1016/j.ceb.2020.03.001

Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration

Autores: Francisco J. Calero-Cuenca, Daniel S. Osorio, Sofia Carvalho-Marques, Sreerama Chaitanya Sridhara, Luis M. Oliveira, Yue Jiao, Jheimmy Diaz, Cátia S. Janota, Bruno Cadot, Edgar R. Gomes
Publicado en: Current Biology, Edición 31/7, 2021, Página(s) 1521-1530.e8, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2021.01.007

MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

Autores: Chiara Galloni, Davide Carra, Jasmine V.G. Abella, Svend Kjær, Pavithra Singaravelu, David J. Barry, Naoko Kogata, Christophe Guérin, Laurent Blanchoin, Michael Way
Publicado en: Journal of Cell Biology, Edición 220/8, 2021, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202102043

Generating fast-twitch myotubes in vitro with an optogenetic-based, quantitative contractility assay

Autores: Hennig, K., Hardman, D., Barata, D.M., Martins, I.I., Bernabeu, M.O., Gomes, E.R., and Roman, W.
Publicado en: Life Science Alliance, 2023, ISSN 2575-1077
Editor: Elsevier Inc.
DOI: 10.26508/lsa.202302227

Biomimetic actin cortices shape cell-sized lipid vesicles.

Autores: Lucia Baldauf, Felix Frey, Marcos Arribas Perez, Miroslav Mladenov, Michael Way, Timon Idema, and Gijsje H Koenderink
Publicado en: BioRxiv, 2023, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.01.15.524117

Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction

Autores: William Roman, Helena Pinheiro, Mafalda R Pimentel, Jessica Segalés, Luis M Oliveira, Esther García-Domínguez, Mari Carmen Gómez-Cabrera, Antonio L Serrano, Edgar R Gomes, Pura Muñoz-Cánoves
Publicado en: science, 2022, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abe5620

Nucleation and stability of branched versus linear Arp2/3-generated actin filaments

Autores: Luyan Cao, Foad Ghasemi, Michael Way, Antoine Jégou and Guillaume Romet-Lemonne
Publicado en: The EMBO Journal, 2023, ISSN 1460-2075
Editor: EMBO Press
DOI: 10.15252/embj.2022113008

Shielding of actin by the endoplasmic reticulum impacts nuclear positioning

Autores: Cátia S. Janota, Andreia Pinto, Anna Pezzarossa,Pedro Machado, Judite Costa, Pedro Campinho, Cláudio A. Franco, Edgar R. Gomes
Publicado en: Nature communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30388-3

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

Autores: Ottilie von Loeffelholz, Andrew Purkiss, Luyan Cao, Svend Kjaer, Naoko Kogata, Guillaume Romet-Lemonne, Michael Way, Carolyn A. Moores
Publicado en: Biology Open, Edición 9/7, 2020, Página(s) bio054304, ISSN 2046-6390
Editor: Biology Open
DOI: 10.1242/bio.054304

mRNA distribution in skeletal muscle is associated with mRNA size.

Autores: Helena Pinheiro, Mafalda Ramos Pimentel, Catarina Sequeira, Luis M Oliveira, Anna Pezzarossa, William Roman, Edgar R Gomes
Publicado en: Journal of Cell Science, 2021, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.256388

ARPC5 Isoforms and Their Regulation by Calcium-Calmodulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells

Autores: Lopamudra Sadhu, Nikolaos Tsopoulidis, Md Hasanuzzaman, Vibor Laketa, Michael Way and Oliver T. Fackler
Publicado en: eLife, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.82450

ARPC5 deficiency leads to severe early onset systemic inflammation and mortality

Autores: Elena Sindram, Andrés Caballero-Oteyza, Naoko Kogata, Shaina Huang, Zahra Alizadeh, Laura Gamez, Mohammad Reza Fazlollhi, Xiao Peng, Bodo Grimbacher, Michael Way and Michele Proietti
Publicado en: Disease Models & Mechanisms, 2023, ISSN 2046-6390
Editor: The Company of Biologists
DOI: 10.1242/dmm.050145

Drosophila motor neuron boutons remodel through membrane blebbing coupled with muscle contraction

Autores: Fernandes, A.R., Martins, J.P., Gomes, E.R., Mendes, C.S., and Teodoro, R.O.
Publicado en: Nature communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-38421-9

Regeneration of actin filament branches from the same Arp2/3 complex

Autores: Foad Ghasemi, LuYan Cao, Miroslav Mladenov, Bérengère Guichard, Michael Way, Antoine Jégou*, and Guillaume Romet-Lemonne
Publicado en: bioRxiv, 2023, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.09.22.558980