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Defining the role of Arp2/3 complex diversity at multiple scales of biology

Project description

A miniature 'tree of life' inside our cells reveals the meaning of its intricacies

Cells are highly active and versatile structures capable of changing shape and moving both in place and within the body. Cell division and migration during development is only one of a myriad of examples. Providing mechanical support and assisting in movement is the cytoskeleton, made of filament-like proteins. Actin is one of these, and the actin-related protein 2/3 (Arp2/3) complex is largely responsible for the creation of an elaborate and branched actin network; it nucleates branched filaments by binding to existing filaments and promoting the growth of new branches. It turns out that the Arp2/3 complex is not one but can exist in eight different combinations of subunits, with differences having dramatic impact on actin networks. The EU-funded ArpComplexity project is untangling all these subunits and their combinations, both structurally and functionally, to better understand what they do, how they do it and why.

Host institution

THE FRANCIS CRICK INSTITUTE LIMITED
Net EU contribution
€ 4 148 087,00
Address
1 Midland Road
NW1 1AT London
United Kingdom

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Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Other funding
€ 4 148 087,00

Beneficiaries (3)

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom
Net EU contribution
€ 4 148 087,00
Address
1 Midland Road
NW1 1AT London

See on map

Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Other funding
€ 4 148 087,00
BIRKBECK COLLEGE - UNIVERSITY OF LONDON
United Kingdom
Net EU contribution
€ 3 359 131,00
Address
Malet Street
WC1E 7HX London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 3 359 131,00
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal
Net EU contribution
€ 3 207 935,00
Address
Avenida Prof Egas Moniz
1649 028 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Research Organisations
Other funding
€ 3 207 935,00