Single-cell genomics to comprehensively understand healthy B-cell maturation and transformation to chronic lymphocytic leukemia

Project Information

BCLLatlas

Grant agreement ID: 810287

DOI

10.3030/810287

Project closed

EC signature date 29 March 2019

Start date 1 April 2019

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 8 333 331,00

EU contribution

€ 8 333 331,00

Coordinated by

CONSORCIO PARA LA EXPLOTACION DEL CENTRO NACIONAL DE ANALISIS GENOMICO
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes

Author(s): Marc Elosua-Bayes, Paula Nieto, Elisabetta Mereu, Ivo Gut, Holger Heyn
Published in: Nucleic Acids Research, Issue 49/9, 2021, Page(s) e50-e50, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab043

Machine learning and multi-omics data in chronic lymphocytic leukemia: the future of precision medicine?

Author(s): Maria Tsagiopoulou, Ivo G. Gut
Published in: Frontiers in Genetics, Issue 14, 2024, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2023.1304661

Fluctuating DNA methylation tracks cancer evolution at clinical scale

Author(s): Calum Gabbutt, Martí Duran-Ferrer, Heather E. Grant, Diego Mallo, Ferran Nadeu, Jacob Househam, Neus Villamor, Madlen Müller, Simon Heath, Emanuele Raineri, Olga Krali, Jessica Nordlund, Thorsten Zenz, Ivo G. Gut, Elias Campo, Armando Lopez-Guillermo, Jude Fitzgibbon, Chris P. Barnes, Darryl Shibata, José I. Martin-Subero, Trevor A. Graham
Published in: Nature, Issue 645, 2025, Page(s) 764-773, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-09374-4

Sampling time-dependent artifacts in single-cell genomics studies

Author(s): Ramon Massoni-Badosa, Giovanni Iacono, Catia Moutinho, Marta Kulis, Núria Palau, Domenica Marchese, Javier Rodríguez-Ubreva, Esteban Ballestar, Gustavo Rodriguez-Esteban, Sara Marsal, Marta Aymerich, Dolors Colomer, Elias Campo, Antonio Julià, José Ignacio Martín-Subero, Holger Heyn
Published in: Genome Biology, Issue 21/1, 2020, ISSN 1474-760X
Publisher: BMC, Nature Publishing Group
DOI: 10.1186/s13059-020-02032-0

The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

Author(s): Martí Duran-Ferrer, Guillem Clot, Ferran Nadeu, Renée Beekman, Tycho Baumann, Jessica Nordlund, Yanara Marincevic-Zuniga, Gudmar Lönnerholm, Alfredo Rivas-Delgado, Silvia Martín, Raquel Ordoñez, Giancarlo Castellano, Marta Kulis, Ana C. Queirós, Seung-Tae Lee, Joseph Wiemels, Romina Royo, Montserrat Puiggrós, Junyan Lu, Eva Giné, Sílvia Beà, Pedro Jares, Xabier Agirre, Felipe Prosper, Ca
Published in: Nature Cancer, Issue 1/11, 2020, Page(s) 1066-1081, ISSN 2662-1347
Publisher: Nature Publishing Group
DOI: 10.1038/s43018-020-00131-2

MYC target gene activation in chronic lymphocytic leukemia and richter transformation: links to aggressiveness and tumor microenvironment interactions

Author(s): M. Tsagiopoulou, S. Rashmi, M. Chatziaslani, I. Gut
Published in: Frontiers in Pharmacology, Issue 16, 2025, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2025.1642458

A method for multiplexed full-length single-molecule sequencing of the human mitochondrial genome

Author(s): Ieva Keraite, Philipp Becker, Davide Canevazzi, Cristina Frias-López, Marc Dabad, Raúl Tonda-Hernandez, Ida Paramonov, Matthew John Ingham, Isabelle Brun-Heath, Jordi Leno, Anna Abulí, Elena Garcia-Arumí, Simon Charles Heath, Marta Gut, Ivo Glynne Gut
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-33530-3

Multi-organ single-cell transcriptomics of immune cells uncovered organ-specific gene expression and functions

Author(s): Maria Tsagiopoulou, Sonal Rashmi, Sergio Aguilar, Juan Nieto, Ivo G. Gut
Published in: Scientific Data, 2026, ISSN 2052-4463
Publisher: Springer Nature
DOI: 10.1101/2023.05.29.542692

IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics

Author(s): Ferran Nadeu, Romina Royo, Guillem Clot, Martí Duran-Ferrer, Alba Navarro, Silvia Martín, Junyan Lu, Thorsten Zenz, Tycho Baumann, Pedro Jares, Xose S. Puente, José I. Martín-Subero, Julio Delgado, Elías Campo
Published in: Blood, Issue 137/21, 2021, Page(s) 2935-2946, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020008311

A single-cell tumor immune atlas for precision oncology

Author(s): Paula Nieto, Marc Elosua-Bayes, Juan L. Trincado, Domenica Marchese, Ramon Massoni-Badosa, Maria Salvany, Ana Henriques, Juan Nieto, Sergio Aguilar-Fernández, Elisabetta Mereu, Catia Moutinho, Sara Ruiz, Patricia Lorden, Vanessa T. Chin, Dominik Kaczorowski, Chia-Ling Chan, Richard Gallagher, Angela Chou, Ester Planas-Rigol, Carlota Rubio-Perez, Ivo Gut, Josep M. Piulats, Joan Seoane, Joseph E. P
Published in: Genome Research, Issue 31/10, 2021, Page(s) 1913-1926, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.273300.120