Project description
Naturally controlled experiments may reveal novel disease predictors from infancy
The ‘Developmental Origins of Health and Disease’ (DOHaD) concept arose from findings more than 30 years ago that low birth weight is predictive of later risk for certain diseases. Since then, research has confirmed that our health and risk of disease throughout life are linked to conditions during the periconceptual period. This is relatively robust and repeatable across species although human studies are fewer given the practical difficulties of experimentation. DohART-NET is training a new cohort of DOHaD researchers through evaluation of links between parents’ periconceptual ‘environment’ (for example their health, chemical stressors or stress) and their babies’ health. The studies are strengthened by inclusion of so-called test-tube babies, one of the best-defined groups in this critical time period.
Objective
Altered conditions during the periconceptional (PC) period of gamete maturation and early embryonic development have long lasting effects on the health of the progeny, including the childhood, adolescent and adult-life onset of cardiovascular, metabolic and neurological diseases (‘Developmental Origins of Health and Disease (DOHaD) concept). Increasing evidence from epidemiological and animal model studies shows that children worldwide exhibit conditions and disease risks associated with the exposures of their parents, including chemical stressors before and during pregnancy, reproductive failure, adverse pregnancy outcome, diabetes, obesity and nutritional compromise. Babies born following human ART (“testtube”)interventions render this population (over 5 million world-wide) one of the largest well-defined clinical cohorts to be studied for a better understanding of the future risk of disease for current and succeeding generations in Europe. The DohART-NET project focus on the integration of pre-clinical (animal and stem cell-models) and clinical studies and apply data linkage, bioinformatics and network science for the identification and validation of mechanisms of diseases common in early development. We will exploit our new understanding to promote efficient disease prevention and potential personalised therapeutic interventions in both the general and ART populations to overcome adverse disease pathways. DohART-NET is optimized for training ESRs due to the facts that: i) the topic is progressive and much needed to improve public health over several generations, and it is integrating basic pre-clinical, translational clinical and in silico modeling approaches, iii) the partnership has a highly multi- and interdisciplinary scientific and training expertise and excellence, iv) there is an existing synergy by collaborations and links that the partners wish to strengthen both in science and lasting training programs in a highly inter-sectorial setting.
Fields of science (EuroSciVoc)
- medical and health sciences health sciences public health
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine obstetrics
- medical and health sciences health sciences nutrition obesity
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-ITN-2018
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2100 Goedoello
Hungary
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Participants (10)
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CB2 1TN CAMBRIDGE
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M13 9PL Manchester
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SO17 1BJ SOUTHAMPTON
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3015 GD Rotterdam
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Participation ended
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1090 Wien
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80539 MUNCHEN
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84184 Tiefenbach
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1050 BRUSSEL
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46015 VALENCIA
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1010 WIEN
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Partners (9)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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46010 Valencia
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1090 WIEN
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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2100 Godollo
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610065 CHENGDU
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OX1 2JD Oxford
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1211 Geneve 6
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EC2Y 5EB London
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1000 Bruxelles / Brussel
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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02453 Waltham Ma
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
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