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Organoids for Virus Research - An innovative training-ETN programme

Deliverables

Report on ethical issues regarding use of human organoids

Report on ethical issues regarding use of human organoids

Report 1 on IAV infection using HAE

Report 1 on IAV infection using HAE

Report 1 on development of different co-culture systems

Report 1 on development of different co-culture systems

Official registration of ESRs in Graduate Schools

Official registration of ESRs in Graduate Schools

Call for applications

Call for applications

Report 1 on picornavirus infection using 3D models

Report 1 on picornavirus infection using 3D models

Report 1 on HCoV infection using 3D models

Report 1 on HCoV infection using 3D models

Supervisory Board of the network

Supervisory Board of the network; mandatory deliverable

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Publications

Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection

Author(s): Inés García-Rodríguez, Adithya Sridhar, Dasja Pajkrt, Katja C. Wolthers
Published in: Viruses, Issue 12/11, 2020, Page(s) 1288, ISSN 1999-4915
DOI: 10.3390/v12111288

Monitoring of enterovirus diversity in wastewater by ultra-deep sequencing: An effective complementary tool for clinical enterovirus surveillance

Author(s): Maxime Bisseux, Didier Debroas, Audrey Mirand, Christine Archimbaud, Hélène Peigue-Lafeuille, Jean-Luc Bailly, Cécile Henquell
Published in: Water Research, Issue 169, 2020, Page(s) 115246, ISSN 0043-1354
DOI: 10.1016/j.watres.2019.115246

Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20

Author(s): Sofie Elisabeth Midgley, Kimberley Benschop, Robert Dyrdak, Audrey Mirand, Jean-Luc Bailly, Sibylle Bierbaum, Stefan Buderus, Sindy Böttcher, Anna-Maria Eis-Hübinger, Mario Hönemann, Veronika Vorobieva Jensen, Ulla Birgitte Hartling, Cécile Henquell, Marcus Panning, Marianne Kragh Thomsen, Emma B Hodcroft, Adam Meijer
Published in: Eurosurveillance, Issue 25/2, 2020, ISSN 1560-7917
DOI: 10.2807/1560-7917.es.2020.25.2.1900749

A Perspective on Organoids for Virology Research

Author(s): Adithya Sridhar, Salvatore Simmini, Carla M. S. Ribeiro, Caroline Tapparel, Melvin M. Evers, Dasja Pajkrt, Katja Wolthers
Published in: Viruses, Issue 12/11, 2020, Page(s) 1341, ISSN 1999-4915
DOI: 10.3390/v12111341

Severe Acute Flaccid Myelitis Associated With Enterovirus in Children: Two Phenotypes for Two Evolution Profiles?

Author(s): Melodie Aubart, Cyril Gitiaux, Charles Joris Roux, Raphael Levy, Isabelle Schuffenecker, Audrey Mirand, Nathalie Bach, Florence Moulin, Jean Bergounioux, Marianne Leruez-Ville, Flore Rozenberg, Delphine Sterlin, Lucile Musset, Denise Antona, Nathalie Boddaert, Shen Ying Zhang, Manoelle Kossorotoff, Isabelle Desguerre
Published in: Frontiers in Neurology, Issue 11, 2020, ISSN 1664-2295
DOI: 10.3389/fneur.2020.00343

Recombination Analysis of Non-Poliovirus Members of the Enterovirus C Species: Restriction of Recombination Events to Members of the Same 3DPol Cluster

Author(s): Lieke Brouwer, Kimberley S.M. Benschop, Dung Nguyen, Everlyn Kamau, Dasja Pajkrt, Peter Simmonds, Katja C. Wolthers
Published in: Viruses, Issue 12/7, 2020, Page(s) 706, ISSN 1999-4915
DOI: 10.3390/v12070706

A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts

Author(s): A. Hayes, D. Nguyen, M. Andersson, A. Antón, J.‐L. Bailly, S. Beard, K. S. M. Benschop, N. Berginc, S. Blomqvist, E. Cunningham, D. Davis, J. L. Dembinski, S. Diedrich, S. G. Dudman, R. Dyrdak, G. J. A. Eltringham, S. Gonzales‐Goggia, R. Gunson, H. C. Howson‐Wells, A. J. Jääskeläinen, F. X. López‐Labrador, M. Maier, M. Majumdar, S. Midgley, A. Mirand, U. Morley, S. A. Nordbø, S. Oika
Published in: Journal of Medical Virology, Issue 92/8, 2020, Page(s) 1065-1074, ISSN 0146-6615
DOI: 10.1002/jmv.25659

A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine

Author(s): Thomas Roodsant, Marit Navis, Ikrame Aknouch, Ingrid B. Renes, Ruurd M. van Elburg, Dasja Pajkrt, Katja C. Wolthers, Constance Schultsz, Kees C. H. van der Ark, Adithya Sridhar, Vanesa Muncan
Published in: Frontiers in Cellular and Infection Microbiology, Issue 10, 2020, ISSN 2235-2988
DOI: 10.3389/fcimb.2020.00272

Parechovirus A Pathogenesis and the Enigma of Genotype A-3

Author(s): Sridhar, Karelehto, Brouwer, Pajkrt, Wolthers
Published in: Viruses, Issue 11/11, 2019, Page(s) 1062, ISSN 1999-4915
DOI: 10.3390/v11111062

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

Author(s): Aleksandra Milewska, Ying Chi, Artur Szczepanski, Emilia Barreto-Duran, Agnieszka Dabrowska, Pawel Botwina, Magdalena Obloza, Kevin Liu, Dan Liu, Xiling Guo, Yiyue Ge, Jingxin Li, Lunbiao Cui, Marek Ochman, Maciej Urlik, Sylwia Rodziewicz-Motowidlo, Fengcai Zhu, Krzysztof Szczubialka, Maria Nowakowska, Krzysztof Pyrc
Published in: Journal of Virology, 2020, ISSN 0022-538X
DOI: 10.1128/jvi.01622-20

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain

Author(s): Josse A. Depla, Marina Sogorb-Gonzalez, Lance A. Mulder, Vivi M. Heine, Pavlina Konstantinova, Sander J. van Deventer, Katja C. Wolthers, Dasja Pajkrt, Adithya Sridhar, Melvin M. Evers
Published in: Molecular Therapy - Methods & Clinical Development, Issue 18, 2020, Page(s) 167-175, ISSN 2329-0501
DOI: 10.1016/j.omtm.2020.05.028

Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study

Author(s): Laura Bubba, Eeva K Broberg, Aftab Jasir, Peter Simmonds, Heli Harvala, Monika Redlberger-Fritz, Lubomira Nikolaeva-Glomb, Martina Havlíčková, Petra Rainetova, Thea K Fischer, Sofie E. Midgley, Jevgenia Epštein, Soile Blomqvist, Sindy Böttcher, Kathrin Keeren, Erika Bujaki, Ágnes Farkas, Guôrún Erna Baldvinsdóttir, Ursula Morley, Cillian De Gascun, Laura Pellegrinelli, Antonio Piralla, Ok
Published in: The Lancet Infectious Diseases, Issue 20/3, 2020, Page(s) 350-361, ISSN 1473-3099
DOI: 10.1016/s1473-3099(19)30566-3

RSV combination therapy using a fusion- and a polymerase inhibitor results in increased potency and delayed development of resistance in human lung organoid cultures

Author(s): Thuc N.D. Do, Auke E.S. de Zwart, Annelies Riezebos-Brilman, Johan Neyts and Dirk Jochmans
Published in: 2020

Mycophenolic Acid Has Intrinsic Antiviral Properties And Potentiates The Antiviral Effect Of Ribavirin On Parainfluenza Virus

Author(s): Auke E.S. de Zwart, Annelies Riezebos-Brilman, Thuc N.D. Do, Huib A.M. Kerstjens, Jan-Willem Alffenaar, Erik A.M. Verschuuren, Johan Neyts and Dirk Jochmans
Published in: 2020

Evaluation of Biocompatibility on 3D-printed Inserts using Mouse Intestinal Organoids

Author(s): Asli Aybike Dogan, Martin Dufva
Published in: 2020