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Organoids for Virus Research - An innovative training-ETN programme

Deliverables

Report on ethical issues regarding use of human organoids

Report on ethical issues regarding use of human organoids

Report 1 on IAV infection using HAE

Report 1 on IAV infection using HAE

Report 1 on development of different co-culture systems

Report 1 on development of different co-culture systems

Official registration of ESRs in Graduate Schools

Official registration of ESRs in Graduate Schools

Call for applications

Call for applications

Report 1 on picornavirus infection using 3D models

Report 1 on picornavirus infection using 3D models

Report 1 on HCoV infection using 3D models

Report 1 on HCoV infection using 3D models

Supervisory Board of the network

Supervisory Board of the network; mandatory deliverable

Publications

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection

Author(s): Aleksandra Synowiec, Artur Szczepański, Emilia Barreto-Duran, Laurensius Kevin Lie, Krzysztof Pyrc
Published in: 2021
Publisher: American Society for Microbiology
DOI: 10.1128/cmr.00133-20

The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

Author(s): Rana Abdelnabi, Caroline S. Foo, Suzanne J.F. Kaptein, Xin Zhang, Thuc Nguyn Dan Do, Lana Langendries, Laura Vangeel, Judith Breuer, Juanita Pang, Rachel Williams, Valentijn Vergote, Elisabeth Heylen, Pieter Leyssen, Kai Dallmeier, Lotte Coelmoont, Arnab K. Chatterjee, Raf Mols, Patrick Augustijns, Steven De Jonghe, Dirk Jochmans, Birgit Weynand, Johan Neyts
Published in: 2021
Publisher: The Lancet
DOI: 10.1016/j.ebiom.2021.103595

Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues

Author(s): Leentje Persoons, Evelien Vanderlinden, Laura Vangeel, Xinyu Wang, Nguyen Dan Thuc Do, Shi-Yan Caroline Foo, Pieter Leyssen, Johan Neyts, Dirk Jochmans, Dominique Schols, Steven De Jonghe
Published in: 2021
Publisher: Science Direct
DOI: 10.1016/j.antiviral.2021.105127

Itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial

Author(s): Laurens Liesenborghs, Isabel Spriet, Dirk Jochmans, Ann Belmans, Iwein Gyselinck, Laure-Anne Teuwen, Sebastiaan ter Horst, Erwin Dreesen, Tatjana Geukens, Matthias M. Engelen, Ewout Landeloos, Vincent Geldhof, Helga Ceunen, Barbara Debaveye, Bert Vandenberk, Lorenz Van der Linden, Sofie Jacobs, Lana Langendries, Robbert Boudewijns, Thuc Nguyen Dan Do, Winston Chiu, Xinyu Wang, Xin Zhang, Birgit We
Published in: 2021
Publisher: Science Direct
DOI: 10.1016/j.ebiom.2021.103454

RSV combination therapy using a fusion- and a polymerase inhibitor results in increased potency and delayed development of resistance in human lung organoid cultures

Author(s): Thuc N.D. Do, Auke E.S. de Zwart, Annelies Riezebos-Brilman, Johan Neyts and Dirk Jochmans
Published in: 2020
Publisher: International Society for Antiviral Research

Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3

Author(s): Inés García-Rodríguez, Hetty van Eijk, Gerrit Koen, Dasja Pajkrt, Adithya Sridhar, and Katja C. Wolthers
Published in: Human Organoid Technology for Virus Research, 2021
Publisher: Frontiers
DOI: 10.3389/fcimb.2021.740662

A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents

Author(s): Thuc Nguyen Do, Kim Donckers, Laura Vangeel, Arnab K. Chatterjee, Philippe A. Gallay, Michael D. Bobardt, John P. Bilello, Tomas Cihlar, Steven De Jonghe, Johan Neyts, Dirk Jochmans.
Published in: 2021
Publisher: Science Direct
DOI: 10.1016/j.antiviral.2021.105122

Mycophenolic Acid Has Intrinsic Antiviral Properties And Potentiates The Antiviral Effect Of Ribavirin On Parainfluenza Virus

Author(s): Auke E.S. de Zwart, Annelies Riezebos-Brilman, Thuc N.D. Do, Huib A.M. Kerstjens, Jan-Willem Alffenaar, Erik A.M. Verschuuren, Johan Neyts and Dirk Jochmans
Published in: 2020
Publisher: International Society for Antiviral Research

World-wide prevalence and genotype distribution of Enteroviruses

Author(s): Lieke Brouwer, Giulia Moreni, Katja C. Wolthers, and Dasja Pajkrt
Published in: Virus, 2021
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/v13030434.

Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection

Author(s): Inés García-Rodríguez, Adithya Sridhar, Dasja Pajkrt, Katja C. Wolthers
Published in: Viruses, 12/11, 2020, Page(s) 1288, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12111288

Monitoring of enterovirus diversity in wastewater by ultra-deep sequencing: An effective complementary tool for clinical enterovirus surveillance

Author(s): Maxime Bisseux, Didier Debroas, Audrey Mirand, Christine Archimbaud, Hélène Peigue-Lafeuille, Jean-Luc Bailly, Cécile Henquell
Published in: Water Research, 169, 2020, Page(s) 115246, ISSN 0043-1354
Publisher: Elsevier BV
DOI: 10.1016/j.watres.2019.115246

Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20

Author(s): Sofie Elisabeth Midgley, Kimberley Benschop, Robert Dyrdak, Audrey Mirand, Jean-Luc Bailly, Sibylle Bierbaum, Stefan Buderus, Sindy Böttcher, Anna-Maria Eis-Hübinger, Mario Hönemann, Veronika Vorobieva Jensen, Ulla Birgitte Hartling, Cécile Henquell, Marcus Panning, Marianne Kragh Thomsen, Emma B Hodcroft, Adam Meijer
Published in: Eurosurveillance, 25/2, 2020, ISSN 1560-7917
Publisher: N/A
DOI: 10.2807/1560-7917.es.2020.25.2.1900749

Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections

Author(s): Santos-Ferreira N, Van Dycke J, Neyts J, Rocha-Pereira J
Published in: Microorganisms, 2021, ISSN 2076-2607
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/microorganisms9081599

A Perspective on Organoids for Virology Research

Author(s): Adithya Sridhar, Salvatore Simmini, Carla M. S. Ribeiro, Caroline Tapparel, Melvin M. Evers, Dasja Pajkrt, Katja Wolthers
Published in: Viruses, 12/11, 2020, Page(s) 1341, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12111341

Structure-Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections

Author(s): Salvatore Ferla, Carmine Varricchio, William Knight, Pui Kei Ho, Fabiana Saporito, Beatrice Tropea, Giulio Gagan, Ben Matthew Fleude, Federica Bevalicqua, Nanci Santos-Ferreira, Jana Van Dycke, Johan Neyts, Andrea Brancale, Joana Rocha-Pereira, and Marcella Bassetto
Published in: Microorganisms, 2021, ISSN 2076-2607
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/microorganisms9091795

Severe Acute Flaccid Myelitis Associated With Enterovirus in Children: Two Phenotypes for Two Evolution Profiles?

Author(s): Melodie Aubart, Cyril Gitiaux, Charles Joris Roux, Raphael Levy, Isabelle Schuffenecker, Audrey Mirand, Nathalie Bach, Florence Moulin, Jean Bergounioux, Marianne Leruez-Ville, Flore Rozenberg, Delphine Sterlin, Lucile Musset, Denise Antona, Nathalie Boddaert, Shen Ying Zhang, Manoelle Kossorotoff, Isabelle Desguerre
Published in: Frontiers in Neurology, 11, 2020, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.00343

A RAD Approach to iBlastoids with a Moral Principle of Complexity

Author(s): Andrew J. Barnhart & Kris Dierickx
Published in: The American Journal of Bioethics, 2021, ISSN 1526-5161
Publisher: MIT Press
DOI: 10.1080/15265161.2021.2001101

Recombination Analysis of Non-Poliovirus Members of the Enterovirus C Species: Restriction of Recombination Events to Members of the Same 3DPol Cluster

Author(s): Lieke Brouwer, Kimberley S.M. Benschop, Dung Nguyen, Everlyn Kamau, Dasja Pajkrt, Peter Simmonds, Katja C. Wolthers
Published in: Viruses, 12/7, 2020, Page(s) 706, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12070706

A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts

Author(s): A. Hayes, D. Nguyen, M. Andersson, A. Antón, J.‐L. Bailly, S. Beard, K. S. M. Benschop, N. Berginc, S. Blomqvist, E. Cunningham, D. Davis, J. L. Dembinski, S. Diedrich, S. G. Dudman, R. Dyrdak, G. J. A. Eltringham, S. Gonzales‐Goggia, R. Gunson, H. C. Howson‐Wells, A. J. Jääskeläinen, F. X. López‐Labrador, M. Maier, M. Majumdar, S. Midgley, A. Mirand, U. Morley, S. A. Nordbø, S. Oika
Published in: Journal of Medical Virology, 92/8, 2020, Page(s) 1065-1074, ISSN 0146-6615
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmv.25659

A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine

Author(s): Thomas Roodsant, Marit Navis, Ikrame Aknouch, Ingrid B. Renes, Ruurd M. van Elburg, Dasja Pajkrt, Katja C. Wolthers, Constance Schultsz, Kees C. H. van der Ark, Adithya Sridhar, Vanesa Muncan
Published in: Frontiers in Cellular and Infection Microbiology, 10, 2020, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2020.00272

Parechovirus A Pathogenesis and the Enigma of Genotype A-3

Author(s): Sridhar, Karelehto, Brouwer, Pajkrt, Wolthers
Published in: Viruses, 11/11, 2019, Page(s) 1062, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11111062

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

Author(s): Aleksandra Milewska, Ying Chi, Artur Szczepanski, Emilia Barreto-Duran, Agnieszka Dabrowska, Pawel Botwina, Magdalena Obloza, Kevin Liu, Dan Liu, Xiling Guo, Yiyue Ge, Jingxin Li, Lunbiao Cui, Marek Ochman, Maciej Urlik, Sylwia Rodziewicz-Motowidlo, Fengcai Zhu, Krzysztof Szczubialka, Maria Nowakowska, Krzysztof Pyrc
Published in: Journal of Virology, 2020, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/jvi.01622-20

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain

Author(s): Josse A. Depla, Marina Sogorb-Gonzalez, Lance A. Mulder, Vivi M. Heine, Pavlina Konstantinova, Sander J. van Deventer, Katja C. Wolthers, Dasja Pajkrt, Adithya Sridhar, Melvin M. Evers
Published in: Molecular Therapy - Methods & Clinical Development, 18, 2020, Page(s) 167-175, ISSN 2329-0501
Publisher: N/A
DOI: 10.1016/j.omtm.2020.05.028

Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study

Author(s): Laura Bubba, Eeva K Broberg, Aftab Jasir, Peter Simmonds, Heli Harvala, Monika Redlberger-Fritz, Lubomira Nikolaeva-Glomb, Martina Havlíčková, Petra Rainetova, Thea K Fischer, Sofie E. Midgley, Jevgenia Epštein, Soile Blomqvist, Sindy Böttcher, Kathrin Keeren, Erika Bujaki, Ágnes Farkas, Guôrún Erna Baldvinsdóttir, Ursula Morley, Cillian De Gascun, Laura Pellegrinelli, Antonio Piralla, Ok
Published in: The Lancet Infectious Diseases, 20/3, 2020, Page(s) 350-361, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(19)30566-3

Interferon-Dependent and Respiratory Virus-Specific Interference in Dual Infections of Airway Epithelia

Author(s): Manel Essaidi-Laziosi, Johan Geiser, Song Huang, Samuel Constant, Laurent Kaiser, Caroline Tapparel
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-66748-6

Evaluation of Biocompatibility on 3D-printed Inserts using Mouse Intestinal Organoids

Author(s): Asli Aybike Dogan, Martin Dufva
Published in: 2020
Publisher: European Organ-on-Chip Society – EUROoCS