Organoids for Virus Research - An innovative training-ETN programme | OrganoVIR | Project | Results | H2020 | CORDIS

Risultati finali

Report 2 on development of different co-culture systems

Report 1 on development of different coculture systems

Report 3 on picornavirus infection using 3D models
Report on ethical issues regarding use of human organoids
Report 1 on IAV infection using HAE
Report 3 on IAV infection using HAE
Report 1 on development of different co-culture systems
Official registration of ESRs in Graduate Schools
Report 3 on HCoV infection using 3D models
Call for applications
Report 1 on picornavirus infection using 3D models
Report 2 on HCoV infection using 3D models
Report on stakeholder analysis for investment in organoid entrepreneurs
Report 1 on HCoV infection using 3D models
Supervisory Board of the network

Supervisory Board of the network; mandatory deliverable

Report 2 on picornavirus infection using 3D models
Report 2 on IAV infection using HAE
Report 3 on development of different co-culture systems

Report 3 on development of different coculture systems

Public accessible organovir website, facebook/twitter account

Pubblicazioni

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection

Autori: Aleksandra Synowiec, Artur Szczepański, Emilia Barreto-Duran, Laurensius Kevin Lie, Krzysztof Pyrc
Pubblicato in: 2021
Editore: American Society for Microbiology
DOI: 10.1128/cmr.00133-20

The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

Autori: Rana Abdelnabi, Caroline S. Foo, Suzanne J.F. Kaptein, Xin Zhang, Thuc Nguyn Dan Do, Lana Langendries, Laura Vangeel, Judith Breuer, Juanita Pang, Rachel Williams, Valentijn Vergote, Elisabeth Heylen, Pieter Leyssen, Kai Dallmeier, Lotte Coelmoont, Arnab K. Chatterjee, Raf Mols, Patrick Augustijns, Steven De Jonghe, Dirk Jochmans, Birgit Weynand, Johan Neyts
Pubblicato in: 2021
Editore: The Lancet
DOI: 10.1016/j.ebiom.2021.103595

Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues

Autori: Leentje Persoons, Evelien Vanderlinden, Laura Vangeel, Xinyu Wang, Nguyen Dan Thuc Do, Shi-Yan Caroline Foo, Pieter Leyssen, Johan Neyts, Dirk Jochmans, Dominique Schols, Steven De Jonghe
Pubblicato in: 2021
Editore: Science Direct
DOI: 10.1016/j.antiviral.2021.105127

Itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial

Autori: Laurens Liesenborghs, Isabel Spriet, Dirk Jochmans, Ann Belmans, Iwein Gyselinck, Laure-Anne Teuwen, Sebastiaan ter Horst, Erwin Dreesen, Tatjana Geukens, Matthias M. Engelen, Ewout Landeloos, Vincent Geldhof, Helga Ceunen, Barbara Debaveye, Bert Vandenberk, Lorenz Van der Linden, Sofie Jacobs, Lana Langendries, Robbert Boudewijns, Thuc Nguyen Dan Do, Winston Chiu, Xinyu Wang, Xin Zhang, Birgit We
Pubblicato in: 2021
Editore: Science Direct
DOI: 10.1016/j.ebiom.2021.103454

Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3

Autori: Inés García-Rodríguez, Hetty van Eijk, Gerrit Koen, Dasja Pajkrt, Adithya Sridhar, and Katja C. Wolthers
Pubblicato in: Human Organoid Technology for Virus Research, 2021
Editore: Frontiers
DOI: 10.3389/fcimb.2021.740662

A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents

Autori: Thuc Nguyen Do, Kim Donckers, Laura Vangeel, Arnab K. Chatterjee, Philippe A. Gallay, Michael D. Bobardt, John P. Bilello, Tomas Cihlar, Steven De Jonghe, Johan Neyts, Dirk Jochmans.
Pubblicato in: 2021
Editore: Science Direct
DOI: 10.1016/j.antiviral.2021.105122

World-wide prevalence and genotype distribution of Enteroviruses

Autori: Lieke Brouwer, Giulia Moreni, Katja C. Wolthers, and Dasja Pajkrt
Pubblicato in: Virus, 2021
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/v13030434.

Cultures and cures: neurodiversity and brain organoids

Autori: Andrew J. Barnhart & Kris Dierickx
Pubblicato in: 2021
Editore: BMC Medical Ethics
DOI: 10.1186/s12910-021-00627-1

Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection

Autori: Inés García-Rodríguez, Adithya Sridhar, Dasja Pajkrt, Katja C. Wolthers
Pubblicato in: Viruses, Numero 12/11, 2020, Pagina/e 1288, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12111288

Monitoring of enterovirus diversity in wastewater by ultra-deep sequencing: An effective complementary tool for clinical enterovirus surveillance

Autori: Maxime Bisseux, Didier Debroas, Audrey Mirand, Christine Archimbaud, Hélène Peigue-Lafeuille, Jean-Luc Bailly, Cécile Henquell
Pubblicato in: Water Research, Numero 169, 2020, Pagina/e 115246, ISSN 0043-1354
Editore: Elsevier BV
DOI: 10.1016/j.watres.2019.115246

Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20

Autori: Sofie Elisabeth Midgley, Kimberley Benschop, Robert Dyrdak, Audrey Mirand, Jean-Luc Bailly, Sibylle Bierbaum, Stefan Buderus, Sindy Böttcher, Anna-Maria Eis-Hübinger, Mario Hönemann, Veronika Vorobieva Jensen, Ulla Birgitte Hartling, Cécile Henquell, Marcus Panning, Marianne Kragh Thomsen, Emma B Hodcroft, Adam Meijer
Pubblicato in: Eurosurveillance, Numero 25/2, 2020, ISSN 1560-7917
Editore: N/A
DOI: 10.2807/1560-7917.es.2020.25.2.1900749

Apical-out airway organoids as a platform for studying viral infections and screening for antiviral drugs

Autori: Georgios Stroulios; Tyler Brown; Giulia Moreni; Douglas Kondro; Alessandro Dei; Allen Eaves; Sharon Louis; Juan Hou; Wing Chang; Dasja Pajkrt; Katja C. Wolthers; Adithya Sridhar; Salvatore Simmini
Pubblicato in: Scientific reports, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-11700-z

Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections

Autori: Santos-Ferreira N, Van Dycke J, Neyts J, Rocha-Pereira J
Pubblicato in: Microorganisms, 2021, ISSN 2076-2607
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/microorganisms9081599

A Perspective on Organoids for Virology Research

Autori: Adithya Sridhar, Salvatore Simmini, Carla M. S. Ribeiro, Caroline Tapparel, Melvin M. Evers, Dasja Pajkrt, Katja Wolthers
Pubblicato in: Viruses, Numero 12/11, 2020, Pagina/e 1341, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12111341

Structure-Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections

Autori: Salvatore Ferla, Carmine Varricchio, William Knight, Pui Kei Ho, Fabiana Saporito, Beatrice Tropea, Giulio Gagan, Ben Matthew Fleude, Federica Bevalicqua, Nanci Santos-Ferreira, Jana Van Dycke, Johan Neyts, Andrea Brancale, Joana Rocha-Pereira, and Marcella Bassetto
Pubblicato in: Microorganisms, 2021, ISSN 2076-2607
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/microorganisms9091795

Severe Acute Flaccid Myelitis Associated With Enterovirus in Children: Two Phenotypes for Two Evolution Profiles?

Autori: Melodie Aubart, Cyril Gitiaux, Charles Joris Roux, Raphael Levy, Isabelle Schuffenecker, Audrey Mirand, Nathalie Bach, Florence Moulin, Jean Bergounioux, Marianne Leruez-Ville, Flore Rozenberg, Delphine Sterlin, Lucile Musset, Denise Antona, Nathalie Boddaert, Shen Ying Zhang, Manoelle Kossorotoff, Isabelle Desguerre
Pubblicato in: Frontiers in Neurology, Numero 11, 2020, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.00343

A RAD Approach to iBlastoids with a Moral Principle of Complexity

Autori: Andrew J. Barnhart & Kris Dierickx
Pubblicato in: The American Journal of Bioethics, 2021, ISSN 1526-5161
Editore: MIT Press
DOI: 10.1080/15265161.2021.2001101

Recombination Analysis of Non-Poliovirus Members of the Enterovirus C Species: Restriction of Recombination Events to Members of the Same 3DPol Cluster

Autori: Lieke Brouwer, Kimberley S.M. Benschop, Dung Nguyen, Everlyn Kamau, Dasja Pajkrt, Peter Simmonds, Katja C. Wolthers
Pubblicato in: Viruses, Numero 12/7, 2020, Pagina/e 706, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12070706

A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts

Autori: A. Hayes, D. Nguyen, M. Andersson, A. Antón, J.‐L. Bailly, S. Beard, K. S. M. Benschop, N. Berginc, S. Blomqvist, E. Cunningham, D. Davis, J. L. Dembinski, S. Diedrich, S. G. Dudman, R. Dyrdak, G. J. A. Eltringham, S. Gonzales‐Goggia, R. Gunson, H. C. Howson‐Wells, A. J. Jääskeläinen, F. X. López‐Labrador, M. Maier, M. Majumdar, S. Midgley, A. Mirand, U. Morley, S. A. Nordbø, S. Oika
Pubblicato in: Journal of Medical Virology, Numero 92/8, 2020, Pagina/e 1065-1074, ISSN 0146-6615
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmv.25659

A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine

Autori: Thomas Roodsant, Marit Navis, Ikrame Aknouch, Ingrid B. Renes, Ruurd M. van Elburg, Dasja Pajkrt, Katja C. Wolthers, Constance Schultsz, Kees C. H. van der Ark, Adithya Sridhar, Vanesa Muncan
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 10, 2020, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2020.00272

Neutrophil Extracellular Traps Do Not Induce Injury and Inflammation in Well-Differentiated RSV-Infected Airway Epithelium

Autori: Rosalie S N Linssen, Adithya Sridhar, Giulia Moreni, Nicole N van der Wel, Job B M van Woensel, Katja C Wolthers, Reinout A Bem
Pubblicato in: Cells, 2022, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11050785

Parechovirus A Pathogenesis and the Enigma of Genotype A-3

Autori: Sridhar, Karelehto, Brouwer, Pajkrt, Wolthers
Pubblicato in: Viruses, Numero 11/11, 2019, Pagina/e 1062, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11111062

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

Autori: Aleksandra Milewska, Ying Chi, Artur Szczepanski, Emilia Barreto-Duran, Agnieszka Dabrowska, Pawel Botwina, Magdalena Obloza, Kevin Liu, Dan Liu, Xiling Guo, Yiyue Ge, Jingxin Li, Lunbiao Cui, Marek Ochman, Maciej Urlik, Sylwia Rodziewicz-Motowidlo, Fengcai Zhu, Krzysztof Szczubialka, Maria Nowakowska, Krzysztof Pyrc
Pubblicato in: Journal of Virology, 2020, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/jvi.01622-20

Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review

Autori: Giulia Moreni, Ikrame Aknouch, Morris Ras, Lieke Brouwer, René Spijker, Carlemi Calitz, Koert J. Stittelaar, Adithya Sridhar, Katja C. Wolthers, Dasja Pajkrt
Pubblicato in: Clinical and Translational Discovery, 2022, ISSN 2768-0622
Editore: John Wiley & Sons
DOI: 10.1002/ctd2.42

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain

Autori: Josse A. Depla, Marina Sogorb-Gonzalez, Lance A. Mulder, Vivi M. Heine, Pavlina Konstantinova, Sander J. van Deventer, Katja C. Wolthers, Dasja Pajkrt, Adithya Sridhar, Melvin M. Evers
Pubblicato in: Molecular Therapy - Methods & Clinical Development, Numero 18, 2020, Pagina/e 167-175, ISSN 2329-0501
Editore: N/A
DOI: 10.1016/j.omtm.2020.05.028

Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study

Autori: Laura Bubba, Eeva K Broberg, Aftab Jasir, Peter Simmonds, Heli Harvala, Monika Redlberger-Fritz, Lubomira Nikolaeva-Glomb, Martina Havlíčková, Petra Rainetova, Thea K Fischer, Sofie E. Midgley, Jevgenia Epštein, Soile Blomqvist, Sindy Böttcher, Kathrin Keeren, Erika Bujaki, Ágnes Farkas, Guôrún Erna Baldvinsdóttir, Ursula Morley, Cillian De Gascun, Laura Pellegrinelli, Antonio Piralla, Ok
Pubblicato in: The Lancet Infectious Diseases, Numero 20/3, 2020, Pagina/e 350-361, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(19)30566-3

Interferon-Dependent and Respiratory Virus-Specific Interference in Dual Infections of Airway Epithelia

Autori: Manel Essaidi-Laziosi, Johan Geiser, Song Huang, Samuel Constant, Laurent Kaiser, Caroline Tapparel
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-66748-6

Organoids for Virus Research - An innovative training-ETN programme

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