Organoids for Virus Research - An innovative training-ETN programme

Informations projet

OrganoVIR

N° de convention de subvention: 812673

DOI

10.3030/812673

Projet clôturé

Date de signature de la CE 30 Août 2018

Date de début 1 Janvier 2019

Date de fin 31 Decembre 2022

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 983 591,88

Contribution de l’UE

€ 3 983 591,88

Coordonné par

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (17)

Report 2 on development of different co-culture systems

Report 1 on development of different coculture systems

Report 3 on picornavirus infection using 3D models
Report on ethical issues regarding use of human organoids
Report 1 on IAV infection using HAE
Report 3 on IAV infection using HAE
Report 1 on development of different co-culture systems
Official registration of ESRs in Graduate Schools
Report 3 on HCoV infection using 3D models
Call for applications
Report 1 on picornavirus infection using 3D models
Report 2 on HCoV infection using 3D models
Report on stakeholder analysis for investment in organoid entrepreneurs
Report 1 on HCoV infection using 3D models
Supervisory Board of the network

Supervisory Board of the network; mandatory deliverable

Report 2 on picornavirus infection using 3D models
Report 2 on IAV infection using HAE
Report 3 on development of different co-culture systems

Report 3 on development of different coculture systems

Websites, patent fillings, videos etc. (1)

Public accessible organovir website, facebook/twitter account

Publications

Other (8)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection

Auteurs: Aleksandra Synowiec, Artur Szczepański, Emilia Barreto-Duran, Laurensius Kevin Lie, Krzysztof Pyrc
Publié dans: 2021
Éditeur: American Society for Microbiology
DOI: 10.1128/cmr.00133-20

The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

Auteurs: Rana Abdelnabi, Caroline S. Foo, Suzanne J.F. Kaptein, Xin Zhang, Thuc Nguyn Dan Do, Lana Langendries, Laura Vangeel, Judith Breuer, Juanita Pang, Rachel Williams, Valentijn Vergote, Elisabeth Heylen, Pieter Leyssen, Kai Dallmeier, Lotte Coelmoont, Arnab K. Chatterjee, Raf Mols, Patrick Augustijns, Steven De Jonghe, Dirk Jochmans, Birgit Weynand, Johan Neyts
Publié dans: 2021
Éditeur: The Lancet
DOI: 10.1016/j.ebiom.2021.103595

Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues

Auteurs: Leentje Persoons, Evelien Vanderlinden, Laura Vangeel, Xinyu Wang, Nguyen Dan Thuc Do, Shi-Yan Caroline Foo, Pieter Leyssen, Johan Neyts, Dirk Jochmans, Dominique Schols, Steven De Jonghe
Publié dans: 2021
Éditeur: Science Direct
DOI: 10.1016/j.antiviral.2021.105127

Itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial

Auteurs: Laurens Liesenborghs, Isabel Spriet, Dirk Jochmans, Ann Belmans, Iwein Gyselinck, Laure-Anne Teuwen, Sebastiaan ter Horst, Erwin Dreesen, Tatjana Geukens, Matthias M. Engelen, Ewout Landeloos, Vincent Geldhof, Helga Ceunen, Barbara Debaveye, Bert Vandenberk, Lorenz Van der Linden, Sofie Jacobs, Lana Langendries, Robbert Boudewijns, Thuc Nguyen Dan Do, Winston Chiu, Xinyu Wang, Xin Zhang, Birgit We
Publié dans: 2021
Éditeur: Science Direct
DOI: 10.1016/j.ebiom.2021.103454

Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3

Auteurs: Inés García-Rodríguez, Hetty van Eijk, Gerrit Koen, Dasja Pajkrt, Adithya Sridhar, and Katja C. Wolthers
Publié dans: Human Organoid Technology for Virus Research, 2021
Éditeur: Frontiers
DOI: 10.3389/fcimb.2021.740662

A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents

Auteurs: Thuc Nguyen Do, Kim Donckers, Laura Vangeel, Arnab K. Chatterjee, Philippe A. Gallay, Michael D. Bobardt, John P. Bilello, Tomas Cihlar, Steven De Jonghe, Johan Neyts, Dirk Jochmans.
Publié dans: 2021
Éditeur: Science Direct
DOI: 10.1016/j.antiviral.2021.105122

World-wide prevalence and genotype distribution of Enteroviruses

Auteurs: Lieke Brouwer, Giulia Moreni, Katja C. Wolthers, and Dasja Pajkrt
Publié dans: Virus, 2021
Éditeur: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/v13030434.

Cultures and cures: neurodiversity and brain organoids

Auteurs: Andrew J. Barnhart & Kris Dierickx
Publié dans: 2021
Éditeur: BMC Medical Ethics
DOI: 10.1186/s12910-021-00627-1

Peer reviewed articles (19)

Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection

Auteurs: Inés García-Rodríguez, Adithya Sridhar, Dasja Pajkrt, Katja C. Wolthers
Publié dans: Viruses, Numéro 12/11, 2020, Page(s) 1288, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12111288

Monitoring of enterovirus diversity in wastewater by ultra-deep sequencing: An effective complementary tool for clinical enterovirus surveillance

Auteurs: Maxime Bisseux, Didier Debroas, Audrey Mirand, Christine Archimbaud, Hélène Peigue-Lafeuille, Jean-Luc Bailly, Cécile Henquell
Publié dans: Water Research, Numéro 169, 2020, Page(s) 115246, ISSN 0043-1354
Éditeur: Elsevier BV
DOI: 10.1016/j.watres.2019.115246

Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20

Auteurs: Sofie Elisabeth Midgley, Kimberley Benschop, Robert Dyrdak, Audrey Mirand, Jean-Luc Bailly, Sibylle Bierbaum, Stefan Buderus, Sindy Böttcher, Anna-Maria Eis-Hübinger, Mario Hönemann, Veronika Vorobieva Jensen, Ulla Birgitte Hartling, Cécile Henquell, Marcus Panning, Marianne Kragh Thomsen, Emma B Hodcroft, Adam Meijer
Publié dans: Eurosurveillance, Numéro 25/2, 2020, ISSN 1560-7917
Éditeur: N/A
DOI: 10.2807/1560-7917.es.2020.25.2.1900749

Apical-out airway organoids as a platform for studying viral infections and screening for antiviral drugs

Auteurs: Georgios Stroulios; Tyler Brown; Giulia Moreni; Douglas Kondro; Alessandro Dei; Allen Eaves; Sharon Louis; Juan Hou; Wing Chang; Dasja Pajkrt; Katja C. Wolthers; Adithya Sridhar; Salvatore Simmini
Publié dans: Scientific reports, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-11700-z

Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections

Auteurs: Santos-Ferreira N, Van Dycke J, Neyts J, Rocha-Pereira J
Publié dans: Microorganisms, 2021, ISSN 2076-2607
Éditeur: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/microorganisms9081599

A Perspective on Organoids for Virology Research

Auteurs: Adithya Sridhar, Salvatore Simmini, Carla M. S. Ribeiro, Caroline Tapparel, Melvin M. Evers, Dasja Pajkrt, Katja Wolthers
Publié dans: Viruses, Numéro 12/11, 2020, Page(s) 1341, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12111341

Structure-Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections

Auteurs: Salvatore Ferla, Carmine Varricchio, William Knight, Pui Kei Ho, Fabiana Saporito, Beatrice Tropea, Giulio Gagan, Ben Matthew Fleude, Federica Bevalicqua, Nanci Santos-Ferreira, Jana Van Dycke, Johan Neyts, Andrea Brancale, Joana Rocha-Pereira, and Marcella Bassetto
Publié dans: Microorganisms, 2021, ISSN 2076-2607
Éditeur: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/microorganisms9091795

Severe Acute Flaccid Myelitis Associated With Enterovirus in Children: Two Phenotypes for Two Evolution Profiles?

Auteurs: Melodie Aubart, Cyril Gitiaux, Charles Joris Roux, Raphael Levy, Isabelle Schuffenecker, Audrey Mirand, Nathalie Bach, Florence Moulin, Jean Bergounioux, Marianne Leruez-Ville, Flore Rozenberg, Delphine Sterlin, Lucile Musset, Denise Antona, Nathalie Boddaert, Shen Ying Zhang, Manoelle Kossorotoff, Isabelle Desguerre
Publié dans: Frontiers in Neurology, Numéro 11, 2020, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.00343

A RAD Approach to iBlastoids with a Moral Principle of Complexity

Auteurs: Andrew J. Barnhart & Kris Dierickx
Publié dans: The American Journal of Bioethics, 2021, ISSN 1526-5161
Éditeur: MIT Press
DOI: 10.1080/15265161.2021.2001101

Recombination Analysis of Non-Poliovirus Members of the Enterovirus C Species: Restriction of Recombination Events to Members of the Same 3DPol Cluster

Auteurs: Lieke Brouwer, Kimberley S.M. Benschop, Dung Nguyen, Everlyn Kamau, Dasja Pajkrt, Peter Simmonds, Katja C. Wolthers
Publié dans: Viruses, Numéro 12/7, 2020, Page(s) 706, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12070706

A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts

Auteurs: A. Hayes, D. Nguyen, M. Andersson, A. Antón, J.‐L. Bailly, S. Beard, K. S. M. Benschop, N. Berginc, S. Blomqvist, E. Cunningham, D. Davis, J. L. Dembinski, S. Diedrich, S. G. Dudman, R. Dyrdak, G. J. A. Eltringham, S. Gonzales‐Goggia, R. Gunson, H. C. Howson‐Wells, A. J. Jääskeläinen, F. X. López‐Labrador, M. Maier, M. Majumdar, S. Midgley, A. Mirand, U. Morley, S. A. Nordbø, S. Oika
Publié dans: Journal of Medical Virology, Numéro 92/8, 2020, Page(s) 1065-1074, ISSN 0146-6615
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/jmv.25659

A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine

Auteurs: Thomas Roodsant, Marit Navis, Ikrame Aknouch, Ingrid B. Renes, Ruurd M. van Elburg, Dasja Pajkrt, Katja C. Wolthers, Constance Schultsz, Kees C. H. van der Ark, Adithya Sridhar, Vanesa Muncan
Publié dans: Frontiers in Cellular and Infection Microbiology, Numéro 10, 2020, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2020.00272

Neutrophil Extracellular Traps Do Not Induce Injury and Inflammation in Well-Differentiated RSV-Infected Airway Epithelium

Auteurs: Rosalie S N Linssen, Adithya Sridhar, Giulia Moreni, Nicole N van der Wel, Job B M van Woensel, Katja C Wolthers, Reinout A Bem
Publié dans: Cells, 2022, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11050785

Parechovirus A Pathogenesis and the Enigma of Genotype A-3

Auteurs: Sridhar, Karelehto, Brouwer, Pajkrt, Wolthers
Publié dans: Viruses, Numéro 11/11, 2019, Page(s) 1062, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11111062

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

Auteurs: Aleksandra Milewska, Ying Chi, Artur Szczepanski, Emilia Barreto-Duran, Agnieszka Dabrowska, Pawel Botwina, Magdalena Obloza, Kevin Liu, Dan Liu, Xiling Guo, Yiyue Ge, Jingxin Li, Lunbiao Cui, Marek Ochman, Maciej Urlik, Sylwia Rodziewicz-Motowidlo, Fengcai Zhu, Krzysztof Szczubialka, Maria Nowakowska, Krzysztof Pyrc
Publié dans: Journal of Virology, 2020, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.01622-20

Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review

Auteurs: Giulia Moreni, Ikrame Aknouch, Morris Ras, Lieke Brouwer, René Spijker, Carlemi Calitz, Koert J. Stittelaar, Adithya Sridhar, Katja C. Wolthers, Dasja Pajkrt
Publié dans: Clinical and Translational Discovery, 2022, ISSN 2768-0622
Éditeur: John Wiley & Sons
DOI: 10.1002/ctd2.42

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain

Auteurs: Josse A. Depla, Marina Sogorb-Gonzalez, Lance A. Mulder, Vivi M. Heine, Pavlina Konstantinova, Sander J. van Deventer, Katja C. Wolthers, Dasja Pajkrt, Adithya Sridhar, Melvin M. Evers
Publié dans: Molecular Therapy - Methods & Clinical Development, Numéro 18, 2020, Page(s) 167-175, ISSN 2329-0501
Éditeur: N/A
DOI: 10.1016/j.omtm.2020.05.028

Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study

Auteurs: Laura Bubba, Eeva K Broberg, Aftab Jasir, Peter Simmonds, Heli Harvala, Monika Redlberger-Fritz, Lubomira Nikolaeva-Glomb, Martina Havlíčková, Petra Rainetova, Thea K Fischer, Sofie E. Midgley, Jevgenia Epštein, Soile Blomqvist, Sindy Böttcher, Kathrin Keeren, Erika Bujaki, Ágnes Farkas, Guôrún Erna Baldvinsdóttir, Ursula Morley, Cillian De Gascun, Laura Pellegrinelli, Antonio Piralla, Ok
Publié dans: The Lancet Infectious Diseases, Numéro 20/3, 2020, Page(s) 350-361, ISSN 1473-3099
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(19)30566-3

Interferon-Dependent and Respiratory Virus-Specific Interference in Dual Infections of Airway Epithelia

Auteurs: Manel Essaidi-Laziosi, Johan Geiser, Song Huang, Samuel Constant, Laurent Kaiser, Caroline Tapparel
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-66748-6