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DELIVERy of advanced therapies for diabetes training network

Deliverables

Data Managament Plan

Data management plan documented and place for the DELIVER consortium

Researcher Declarations

Researcher declarations for ESRs available.

4th Network Training Event Report

4th Network Training Event Report on activities held at EXPLORA

PhD theses

PhD theses available from ESRs at the end of the programme

Website and social media setup

Public website and social media presence established.

Publications

Fluorescence lifetime metabolic mapping of hypoxia-induced damage in pancreatic pseudo-islets

Author(s): Zbinden A, Carvajal Berrio DA, Urbanczyk M, Layland SL, Bosch M, Fliri S, Lu CE, Jeyagaran A, Loskill P, Duffy GP, Schenke-Layland K.
Published in: Journal of Biophotonics, 2020, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.202000375

Decorin improves human pancreatic β-cell function and regulates ECM expression in vitro

Author(s): Jeyagaran, Aline Zbinden, Chuan-En Lu, Julia Marzi, Laurence Kuhlburger, Sven Nahnsen, Shannon L Layland, Garry Duffy, Katja Schenke-Layland
Published in: Journal of the International Society of Matrix Biology, Issue 2023 Jan;115:160-183, 2023, ISSN 0945-053X
Publisher: Elsevier BV
DOI: 10.1016/j.matbio.2022.12.005

Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform

Author(s): William Whyte, Debkalpa Goswami, Sophie X Wang, Yiling Fan, Niamh A Ward, Ruth E Levey, Rachel Beatty, Scott T Robinson, Declan Sheppard, Raymond O'Connor, David S Monahan, Lesley Trask, Keegan L Mendez, Claudia E Varela, Markus A Horvath, Robert Wylie, Joanne O'Dwyer, Daniel A Domingo-Lopez, Arielle S Rothman, Garry P Duffy, Eimear B Dolan, Ellen T Roche 
Published in: Nature Communications, Issue 2022 Aug 3;13(1):4496, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32147-w

Type 1 diabetes and engineering enhanced islet transplantation

Author(s): Abiramy Jeyagaran, Chuan-En Lu , Aline Zbinden, Andreas L Birkenfeld, Sara Y Brucker, Shannon L Layland
Published in: Advanced Drug Delivery Reviews, Issue 2022 Oct;189:114481, 2022, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2022.114481

A Predictive Oxygen Durability Model to Analyze Oxygen Consumption of Insulin Producing Cells Encapsulated Within a Highly Oxygenated Hydrogel

Author(s): Daniel A. Domingo-Lopez, Ruth E. Levey, Benjamin Brennan, Oliver Carroll, Sarah E. Gale, Jeffrey R. Millman, Liam McDonough, Helena M. Kelly, William Ronan, Garry P. Duffy
Published in: Advanced Materials Technologies, Issue 2023, Vol.8(1), p.2200643, 2022, ISSN 2365-709X
Publisher: Advanced Materials Technologies
DOI: 10.1002/admt.202200643

Medical devices, smart drug delivery, wearables and technology for the treatment of Diabetes Mellitus

Author(s): Daniel A. Domingo-Lopez a 1, Giulia Lattanzi a 1, Lucien H. J. Schreiber a 1, Eimear J. Wallace a 1, Robert Wylie a, Janice O'Sullivan a, Eimear B. Dolan b d, Garry P. Duffy 
Published in: Advanced Drug Delivery Reviews, Issue Volume 185, June 2022, 2022, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2022.114280

The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model

Author(s): Rachel Beatty, Chuan-En Lu, Julia Marzi, Ruth E. Levey, Daniel Carvajal Berrio, Giulia Lattanzi, Robert Wylie, Raymond O'Connor, Eimear Wallace, Giulio Ghersi, Monica Salamone, Eimear B. Dolan, Shannon L. Layland, Katja Schenke-Layland, and Garry P. Duffy
Published in: Tissue Engineering Part C: Methods, Issue Vol. 27, No. 10, 2021, Page(s) 515-528, ISSN 1937-3384
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2021.0163

Tethering zwitterionic polymer coatings to mediated glucose biosensor enzyme electrodes can decrease sensor foreign body response yet retain sensor sensitivity to glucose

Author(s): Kavita Jayakumar, Anna Lielpetere, Daniel A. Domingo-Lopez, Ruth E. Levey, Garry P. Duffy, Wolfgang Schuhmann, Dónal Leech 
Published in: Biosensors and Bioelectronics, Issue Volume 219, 1 January 2023, 2023, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2022.114815

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