Interdisciplinary training network for advancing Organ-on-a-chip technology in Europe

Project Information

EUROoC

Grant agreement ID: 812954

DOI 10.3030/812954

Project closed

EC signature date 21 August 2018

Start date 1 December 2018

End date 31 May 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 942 860,76

EU contribution € 3 942 860,76

Coordinated by

NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN
Germany

Deliverables

Websites, patent fillings, videos etc. (11)

Publication of semi-annual newsletter M48

Publication of semiannual newsletter Month 48

Publication of semi-annual newsletter M42

Publication of semiannual newsletter Month 42

Publication of semi-annual newsletter M6

Publication of semi-annual newsletter Month 6

Publication of semi-annual newsletter M30

Publication of semiannual newsletter Month 30

Publication of semi-annual newsletter M12

Publication of semi-annual newsletter Month 12

Slides and directions for Public Lectures
Website, LinkedIn group, and Twitter account established
Publication of semi-annual newsletter M18

Publication of semi-annual newsletter Month 18

Publication of semi-annual newsletter M24

Publication of semi-annual newsletter Month 24

Publication of semi-annual newsletter M36

Publication of semiannual newsletter Month 36

Compilation of the ESR’s Introductory Video Clips

Documents, reports (1)

Press releases of major findings & developments

Press releases of major findings developments

Other (3)

EUROoC Conference
Successful EUROoC 3R Lab Tours
Recruitment process finalised & all ESRs enrolled in PhD programme

Publications

Peer reviewed articles (23)

Emulating the gut–liver axis: Dissecting the microbiome's effect on drug metabolism using multiorgan-on-chip models

Author(s): Mara Lucchetti, Mathilda Kaminska, Aina Kehinde Oluwasegun, Alexander S. Mosig, Paul Wilmes
Published in: Current Opinion in Endocrine and Metabolic Research, Issue 2021, Volume 18, 2021, Page(s) 91-101, ISSN 2451-9650
Publisher: Elsevier
DOI: 10.1016/j.coemr.2021.03.003

Perspectives for Future Use of Cardiac Microtissues from Human Pluripotent Stem Cells

Author(s): Arslan, U.; Orlova, V.V.; Mummery, C.L.
Published in: ACS Biomaterials Science and Engineering, Issue 2022, 8, 11,, 2022, Page(s) 4605–4609, ISSN 2373-9878
Publisher: ACS
DOI: 10.1021/acsbiomaterials.1c01296

Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model

Author(s): Stefanie Deinhardt-Emmer, Knut Rennert, Elisabeth Schicke, Zoltán Cseresnyés, Maximilian Windolph, Sandor Nietzsche, Regine Heller, Fatina Siwczak, Karoline Frieda Haupt, Swen Carlstedt, Michael Schacke, Marc Thilo Figge, Christina Ehrhardt, Bettina Löffler, Alexander S Mosig
Published in: Biofabrication, Issue 12/2, 2020, Page(s) 025012, ISSN 1758-5090
Publisher: IOP Publishing Ltd
DOI: 10.1088/1758-5090/ab7073

A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading

Author(s): Julia Scheinpflug Chris Tina Höfer, Sarah S. Schmerbeck, Matthias Steinfath, Jennifer Doka, Yonatan Afework Tesfahunegn, Norman Violet, Kostja Renko, Konrad Gulich, Thilo John, Marlon R. Schneider, Elisa Wistorf , Gilbert Schönfelder and Frank Schulze
Published in: Lab on a Chip, Issue 2023, Volume 15, 2023, Page(s) 3405-3423, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3lc00154g

Applicability of organ-on-chip systems in toxicology and pharmacology

Author(s): Marlon R. Schneider, Michael Oelgeschlaeger, Tanja Burgdorf, Peter van Meer, Peter Theunissen, Anne S. Kienhuis, Aldert H. Piersma & Rob J. Vandebriel
Published in: Critical Reviews in Toxicology, Issue 2021, 51(6), 2021, Page(s) 540-554, ISSN 1547-6898
Publisher: Taylor & Francis
DOI: 10.1080/10408444.2021.1953439

Autologous Human Immunocompetent White Adipose Tissue-on-Chip

Author(s): Julia Rogal, Julia Roosz, Claudia Teufel, Madalena Cipriano, Raylin Xu, Wiebke Eisler, Martin Weiss, Katja Schenke-Layland, Peter Loskill
Published in: Advanced Science, Issue 2022, Volume 9(18), 2022, Page(s) 2104451, ISSN 2198-3844
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/advs.202104451

Fusing spheroids to aligned μ-tissues in a heart-on-chip featuring oxygen sensing and electrical pacing capabilities

Author(s): Oliver Schneider; Alessia Moruzzi; Stefanie Fuchs; Alina Grobel; Henrike S. Schulze; Torsten Mayr; Peter Loskill
Published in: Materials Today Bio , Issue Volume 15, 2022, Page(s) 100280, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2022.100280

Microphysiological stem cell models of the human heart

Author(s): Ulgu Arslan; Alessia Moruzzi; Joanna Nowacka; Christine L. Mummery; Dominik Eckardt; Peter Loskill; Valeria V. Orlova
Published in: Materials Today Bio, Issue Volume 14, 2022, 2022, Page(s) 100259, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2022.100259

Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model

Author(s): Katja Graf, Antonia Last, Rena Gratz, Stefanie Allert, Susanne Linde, Martin Westermann, Marko Gröger, Alexander S. Mosig, Mark S. Gresnigt, Bernhard Hube
Published in: Disease Models & Mechanisms, Issue 12/9, 2019, Page(s) dmm039719, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.039719

Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction

Author(s): Fatina Siwczak; Elise Loffet; Mathilda Kaminska; Hristina Koceva; Maxime M. Mahe; Maxime M. Mahe; Maxime M. Mahe; Alexander S. Mosig
Published in: Frontiers in Immunology, Issue 2021, Volume 12, 2021, Page(s) 798552, ISSN 1664-3224
Publisher: Frontires
DOI: 10.3389/fimmu.2021.798552

Vascularized hiPSC-derived 3D cardiac microtissue on chip

Author(s): Ulgu Arslan, Marcella Brescia, Viviana Meraviglia, Dennis Nahon, Ruben van Helden, Marc Vila Cuenca, Jeroen Stein, Francijna E. van den Hil, Berend van Meer, Christine Mummery, Valeria Orlova
Published in: Stem Cell Reports, Issue 2023, Volume 18(7), 2023, Page(s) 1394-1404, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2023.06.001

Three-Dimensional Vessels-on-a-Chip Based on hiPSC-derived Vascular Endothelial and Smooth Muscle Cells

Author(s): Bulut, M., Cuenca, M.V., Graaf, M., Hil, F.E., Mummery, C.L., and Orlova, V.V.
Published in: Current Protocols, Issue 2022, Volume 2, 2022, Page(s) e564, ISSN 2691-1299
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/cpz1.564

A versatile and customizable low-cost 3D-printed open standard for microscopic imaging

Author(s): Benedict Diederich, René Lachmann, Swen Carlstedt, Barbora Marsikova, Haoran Wang, Xavier Uwurukundo, Alexander S. Mosig, Rainer Heintzmann
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19447-9

On-chip analysis of glycolysis and mitochondrial respiration in human induced pluripotent stem cells

Author(s): Fuchs S, Helden RWJ van, Wiendels M, Graaf MNS de, Orlova VV, Mummery CL, Meer BJ van, Mayr T
Published in: Materials Today Bio, Issue 2022, Volume 17(15), 2022, Page(s) 100475, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2022.100475

Optical glucose sensor for microfluidic cell culture systems

Author(s): Stefanie Fuchs, Veronika Rieger, Anders Ø. Tjell, Sarah Spitz, Konstanze Brandauer, Roland Schaller-Ammann, Jürgen Feiel, Peter Ertl, Ingo Klimant, Torsten Mayr
Published in: Biosensors and Bioelectronics, Issue 2023, Volume 237, 2023, Page(s) 115491, ISSN 1873-4235
Publisher: Elsevier
DOI: 10.1016/j.bios.2023.115491

Integration of immune cells in organs-on-chips: a tutorial

Author(s): Van Os L., Engelhardt B., Guenat OT.
Published in: Frontiers in Bioengineering and Biotechnology, Issue 2023, Volume 11, 2023, Page(s) 1191104, ISSN 2296-4185
Publisher: Frontires
DOI: 10.3389/fbioe.2023.1191104

Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics

Author(s): Tanvi Shroff, Kehinde Aina, Christian Maass, Madalena Cipriano, Joeri Lambrecht, Frank Tacke, Alexander Mosig and Peter Loskill
Published in: Open Biology, Issue 2022, Volume 12(3), 2022, Page(s) 210333, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1098/rsob.210333

A microfluidic chip carrier including temperature control and perfusion system for long-term cell imaging

Author(s): Federico Cantoni, Gabriel Werr, Laurent Barbe, Ana Maria Porras, Maria Tenje
Published in: HardwareX, Issue 2021, Volume 10, 2021, Page(s) e00245, ISSN 2468-0672
Publisher: Elsevier
DOI: 10.1016/j.ohx.2021.e00245

Training the next generation of researchers in the Organ-on-Chip field

Author(s): Alessia Moruzzi; Tanvi Shroff; Silke Keller; Peter Loskill; Madalena Cipriano
Published in: Education Sciences, Issue 2023 Volume 13(2), 2023, Page(s) 144, ISSN 2227-7102
Publisher: MDPI
DOI: 10.1101/2022.08.03.502617

Immune cell extravasation in an organ-on-chip to model lung inflammation.

Author(s): van Os L, Yeoh J, Witz G, Ferrari D, Krebs P, Chandorkar Y, Zeinali S, Sengupta A, Guenat OT
Published in: European journal of pharmaceutical Sciences, Issue 2023, Volume 187, 2023, Page(s) 106485, ISSN 1879-0720
Publisher: Elsevier
DOI: 10.1016/j.ejps.2023.106485

Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages

Author(s): Elisabeth Schicke, Zoltán Cseresnyés, Knut Rennert, Vanessa Vau, Karoline Frieda Haupt, Franziska Hornung, Sandor Nietzsche, Fatina Swiczak, Michaela Schmidtke, Brigitte Glück, Mirijam Koch, Michael Schacke, Regine Heller, Alexander S. Mosig, Marc Thilo Figge, Christina Ehrhardt, Bettina Löffler, Stefanie Deinhardt-Emmer
Published in: Microorganisms, Issue 8/4, 2020, Page(s) 577, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms8040577

In-Line Analysis of Organ-on-Chip Systems with Sensors: Integration, Fabrication, Challenges, and Potential

Author(s): Stefanie Fuchs, Sofia Johansson, Anders Ø. Tjell, Gabriel Werr, Torsten Mayr, and Maria Tenje
Published in: ACS Biomaterials Science & Engineering, Issue 2021, Volume 7(7), 2021, Page(s) 2926-2948, ISSN 2373-9878
Publisher: ACS
DOI: 10.1021/acsbiomaterials.0c01110

A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies

Author(s): Maurer, M., Gresnigt, M. S., Last, A., Wollny, T., Berlinghof, F., Pospich, R., Cseresnyes, Z., Medyukhina, A., Graf, K., Gröger, M., Raasch, M., Siwczak, F., Nietsche, S., Jacobsen, I. D., Figge, M. T., Hube, B.m Huber, O., Mosig, A. S.
Published in: Biomaterials, Issue 2019, Volume 220, 2019, Page(s) 119396, ISSN 1878-5905
Publisher: Elsevier
DOI: 10.1016/j.biomaterials.2019.119396