Interdisciplinary training network for advancing Organ-on-a-chip technology in Europe

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Publication of semi-annual newsletter M48

Publication of semiannual newsletter Month 48

Publication of semi-annual newsletter M42

Publication of semiannual newsletter Month 42

Publication of semi-annual newsletter M6

Publication of semi-annual newsletter Month 6

Publication of semi-annual newsletter M30

Publication of semiannual newsletter Month 30

Publication of semi-annual newsletter M12

Publication of semi-annual newsletter Month 12

Slides and directions for Public Lectures
Website, LinkedIn group, and Twitter account established
Publication of semi-annual newsletter M18

Publication of semi-annual newsletter Month 18

Publication of semi-annual newsletter M24

Publication of semi-annual newsletter Month 24

Publication of semi-annual newsletter M36

Publication of semiannual newsletter Month 36

Compilation of the ESR’s Introductory Video Clips

Press releases of major findings & developments

Press releases of major findings developments

EUROoC Conference
Successful EUROoC 3R Lab Tours
Recruitment process finalised & all ESRs enrolled in PhD programme

Publications

Emulating the gut–liver axis: Dissecting the microbiome's effect on drug metabolism using multiorgan-on-chip models

Auteurs: Mara Lucchetti, Mathilda Kaminska, Aina Kehinde Oluwasegun, Alexander S. Mosig, Paul Wilmes
Publié dans: Current Opinion in Endocrine and Metabolic Research, Numéro 2021, Volume 18, 2021, Page(s) 91-101, ISSN 2451-9650
Éditeur: Elsevier
DOI: 10.1016/j.coemr.2021.03.003

Perspectives for Future Use of Cardiac Microtissues from Human Pluripotent Stem Cells

Auteurs: Arslan, U.; Orlova, V.V.; Mummery, C.L.
Publié dans: ACS Biomaterials Science and Engineering, Numéro 2022, 8, 11,, 2022, Page(s) 4605–4609, ISSN 2373-9878
Éditeur: ACS
DOI: 10.1021/acsbiomaterials.1c01296

Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model

Auteurs: Stefanie Deinhardt-Emmer, Knut Rennert, Elisabeth Schicke, Zoltán Cseresnyés, Maximilian Windolph, Sandor Nietzsche, Regine Heller, Fatina Siwczak, Karoline Frieda Haupt, Swen Carlstedt, Michael Schacke, Marc Thilo Figge, Christina Ehrhardt, Bettina Löffler, Alexander S Mosig
Publié dans: Biofabrication, Numéro 12/2, 2020, Page(s) 025012, ISSN 1758-5090
Éditeur: IOP Publishing Ltd
DOI: 10.1088/1758-5090/ab7073

A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading

Auteurs: Julia Scheinpflug Chris Tina Höfer, Sarah S. Schmerbeck, Matthias Steinfath, Jennifer Doka, Yonatan Afework Tesfahunegn, Norman Violet, Kostja Renko, Konrad Gulich, Thilo John, Marlon R. Schneider, Elisa Wistorf , Gilbert Schönfelder and Frank Schulze
Publié dans: Lab on a Chip, Numéro 2023, Volume 15, 2023, Page(s) 3405-3423, ISSN 1473-0197
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d3lc00154g

Applicability of organ-on-chip systems in toxicology and pharmacology

Auteurs: Marlon R. Schneider, Michael Oelgeschlaeger, Tanja Burgdorf, Peter van Meer, Peter Theunissen, Anne S. Kienhuis, Aldert H. Piersma & Rob J. Vandebriel
Publié dans: Critical Reviews in Toxicology, Numéro 2021, 51(6), 2021, Page(s) 540-554, ISSN 1547-6898
Éditeur: Taylor & Francis
DOI: 10.1080/10408444.2021.1953439

Autologous Human Immunocompetent White Adipose Tissue-on-Chip

Auteurs: Julia Rogal, Julia Roosz, Claudia Teufel, Madalena Cipriano, Raylin Xu, Wiebke Eisler, Martin Weiss, Katja Schenke-Layland, Peter Loskill
Publié dans: Advanced Science, Numéro 2022, Volume 9(18), 2022, Page(s) 2104451, ISSN 2198-3844
Éditeur: John Wiley & Sons, Inc.
DOI: 10.1002/advs.202104451

Fusing spheroids to aligned μ-tissues in a heart-on-chip featuring oxygen sensing and electrical pacing capabilities

Auteurs: Oliver Schneider; Alessia Moruzzi; Stefanie Fuchs; Alina Grobel; Henrike S. Schulze; Torsten Mayr; Peter Loskill
Publié dans: Materials Today Bio , Numéro Volume 15, 2022, Page(s) 100280, ISSN 2590-0064
Éditeur: Elsevier
DOI: 10.1016/j.mtbio.2022.100280

Microphysiological stem cell models of the human heart

Auteurs: Ulgu Arslan; Alessia Moruzzi; Joanna Nowacka; Christine L. Mummery; Dominik Eckardt; Peter Loskill; Valeria V. Orlova
Publié dans: Materials Today Bio, Numéro Volume 14, 2022, 2022, Page(s) 100259, ISSN 2590-0064
Éditeur: Elsevier
DOI: 10.1016/j.mtbio.2022.100259

Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model

Auteurs: Katja Graf, Antonia Last, Rena Gratz, Stefanie Allert, Susanne Linde, Martin Westermann, Marko Gröger, Alexander S. Mosig, Mark S. Gresnigt, Bernhard Hube
Publié dans: Disease Models & Mechanisms, Numéro 12/9, 2019, Page(s) dmm039719, ISSN 1754-8403
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/dmm.039719

Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction

Auteurs: Fatina Siwczak; Elise Loffet; Mathilda Kaminska; Hristina Koceva; Maxime M. Mahe; Maxime M. Mahe; Maxime M. Mahe; Alexander S. Mosig
Publié dans: Frontiers in Immunology, Numéro 2021, Volume 12, 2021, Page(s) 798552, ISSN 1664-3224
Éditeur: Frontires
DOI: 10.3389/fimmu.2021.798552

Vascularized hiPSC-derived 3D cardiac microtissue on chip

Auteurs: Ulgu Arslan, Marcella Brescia, Viviana Meraviglia, Dennis Nahon, Ruben van Helden, Marc Vila Cuenca, Jeroen Stein, Francijna E. van den Hil, Berend van Meer, Christine Mummery, Valeria Orlova
Publié dans: Stem Cell Reports, Numéro 2023, Volume 18(7), 2023, Page(s) 1394-1404, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2023.06.001

Three-Dimensional Vessels-on-a-Chip Based on hiPSC-derived Vascular Endothelial and Smooth Muscle Cells

Auteurs: Bulut, M., Cuenca, M.V., Graaf, M., Hil, F.E., Mummery, C.L., and Orlova, V.V.
Publié dans: Current Protocols, Numéro 2022, Volume 2, 2022, Page(s) e564, ISSN 2691-1299
Éditeur: John Wiley & Sons, Inc.
DOI: 10.1002/cpz1.564

A versatile and customizable low-cost 3D-printed open standard for microscopic imaging

Auteurs: Benedict Diederich, René Lachmann, Swen Carlstedt, Barbora Marsikova, Haoran Wang, Xavier Uwurukundo, Alexander S. Mosig, Rainer Heintzmann
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-19447-9

On-chip analysis of glycolysis and mitochondrial respiration in human induced pluripotent stem cells

Auteurs: Fuchs S, Helden RWJ van, Wiendels M, Graaf MNS de, Orlova VV, Mummery CL, Meer BJ van, Mayr T
Publié dans: Materials Today Bio, Numéro 2022, Volume 17(15), 2022, Page(s) 100475, ISSN 2590-0064
Éditeur: Elsevier
DOI: 10.1016/j.mtbio.2022.100475

Optical glucose sensor for microfluidic cell culture systems

Auteurs: Stefanie Fuchs, Veronika Rieger, Anders Ø. Tjell, Sarah Spitz, Konstanze Brandauer, Roland Schaller-Ammann, Jürgen Feiel, Peter Ertl, Ingo Klimant, Torsten Mayr
Publié dans: Biosensors and Bioelectronics, Numéro 2023, Volume 237, 2023, Page(s) 115491, ISSN 1873-4235
Éditeur: Elsevier
DOI: 10.1016/j.bios.2023.115491

Integration of immune cells in organs-on-chips: a tutorial

Auteurs: Van Os L., Engelhardt B., Guenat OT.
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 2023, Volume 11, 2023, Page(s) 1191104, ISSN 2296-4185
Éditeur: Frontires
DOI: 10.3389/fbioe.2023.1191104

Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics

Auteurs: Tanvi Shroff, Kehinde Aina, Christian Maass, Madalena Cipriano, Joeri Lambrecht, Frank Tacke, Alexander Mosig and Peter Loskill
Publié dans: Open Biology, Numéro 2022, Volume 12(3), 2022, Page(s) 210333, ISSN 2046-2441
Éditeur: Royal Society Publishing
DOI: 10.1098/rsob.210333

A microfluidic chip carrier including temperature control and perfusion system for long-term cell imaging

Auteurs: Federico Cantoni, Gabriel Werr, Laurent Barbe, Ana Maria Porras, Maria Tenje
Publié dans: HardwareX, Numéro 2021, Volume 10, 2021, Page(s) e00245, ISSN 2468-0672
Éditeur: Elsevier
DOI: 10.1016/j.ohx.2021.e00245

Training the next generation of researchers in the Organ-on-Chip field

Auteurs: Alessia Moruzzi; Tanvi Shroff; Silke Keller; Peter Loskill; Madalena Cipriano
Publié dans: Education Sciences, Numéro 2023 Volume 13(2), 2023, Page(s) 144, ISSN 2227-7102
Éditeur: MDPI
DOI: 10.1101/2022.08.03.502617

Immune cell extravasation in an organ-on-chip to model lung inflammation.

Auteurs: van Os L, Yeoh J, Witz G, Ferrari D, Krebs P, Chandorkar Y, Zeinali S, Sengupta A, Guenat OT
Publié dans: European journal of pharmaceutical Sciences, Numéro 2023, Volume 187, 2023, Page(s) 106485, ISSN 1879-0720
Éditeur: Elsevier
DOI: 10.1016/j.ejps.2023.106485

Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages

Auteurs: Elisabeth Schicke, Zoltán Cseresnyés, Knut Rennert, Vanessa Vau, Karoline Frieda Haupt, Franziska Hornung, Sandor Nietzsche, Fatina Swiczak, Michaela Schmidtke, Brigitte Glück, Mirijam Koch, Michael Schacke, Regine Heller, Alexander S. Mosig, Marc Thilo Figge, Christina Ehrhardt, Bettina Löffler, Stefanie Deinhardt-Emmer
Publié dans: Microorganisms, Numéro 8/4, 2020, Page(s) 577, ISSN 2076-2607
Éditeur: MDPI
DOI: 10.3390/microorganisms8040577

In-Line Analysis of Organ-on-Chip Systems with Sensors: Integration, Fabrication, Challenges, and Potential

Auteurs: Stefanie Fuchs, Sofia Johansson, Anders Ø. Tjell, Gabriel Werr, Torsten Mayr, and Maria Tenje
Publié dans: ACS Biomaterials Science & Engineering, Numéro 2021, Volume 7(7), 2021, Page(s) 2926-2948, ISSN 2373-9878
Éditeur: ACS
DOI: 10.1021/acsbiomaterials.0c01110

A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies

Auteurs: Maurer, M., Gresnigt, M. S., Last, A., Wollny, T., Berlinghof, F., Pospich, R., Cseresnyes, Z., Medyukhina, A., Graf, K., Gröger, M., Raasch, M., Siwczak, F., Nietsche, S., Jacobsen, I. D., Figge, M. T., Hube, B.m Huber, O., Mosig, A. S.
Publié dans: Biomaterials, Numéro 2019, Volume 220, 2019, Page(s) 119396, ISSN 1878-5905
Éditeur: Elsevier
DOI: 10.1016/j.biomaterials.2019.119396

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