Novel Biomaterial-based Device for the Treatment of Progressive MS- - An Integrated Pan- European Approach

Información del proyecto

PMSMatTrain

Identificador del acuerdo de subvención: 813263

DOI

10.3030/813263

Proyecto cerrado

Fecha de la firma de la CE 9 Abril 2019

Fecha de inicio 1 Mayo 2019

Fecha de finalización 31 Enero 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 962 143,44

Aportación de la UE

€ 3 962 143,44

Coordinado por

UNIVERSITY OF GALWAY
Ireland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (3)

Conference presentations (M 8, M12, M16, M20, M24, M32, M36, M42)

With input from all partners, the Management Team and the Dissemination and Outreach Committee (TC), this WP will ensure all aspects of Dissemination, Exploitation and Public Engagement are managed appropriately.

Manuscripts (M 20, M 24, M36, M40, M 45

With input from all partners, the Management Team and the Dissemination and Outreach Committee (TC), this WP will ensure all aspects of Dissemination, Exploitation and Public Engagement are managed appropriately.

Press Releases

With input from all partners, the Management Team and the Dissemination and Outreach Committee (TC), this WP will ensure all aspects of Dissemination, Exploitation and Public Engagement are managed appropriately.

Open Research Data Pilot (1)

Data Management Plan

Data management plan to be provided for open access data

Documents, reports (4)

Periodic reviews of the RPDPs and PhD progression (Month 12, 24, 36 and 48)

With input from all partners at the Supervisory Board and Training Committee (TC), this WP will ensure all aspects of the education and training programme are met.

Attendance at Open Days and Science Fairs (M12, M24, M36, M48)

With input from all partners, the Management Team and the Dissemination and Outreach Committee (TC), this WP will ensure all aspects of Dissemination, Exploitation and Public Engagement are managed appropriately.

Local training courses held

With input from all partners at the Supervisory Board and Training Committee (TC), this WP will ensure all aspects of the education and training programme are met.

Completion of ESR credits in transferable skills

With input from all partners at the Supervisory Board and Training Committee (TC), this WP will ensure all aspects of the education and training programme are met.

Publicaciones

Conference proceedings (14)

Brain Proteomic Signatures of an in vivo Model ofMultiple Sclerosis

Autores: M. Fucito, B. Ojha, R. Khorooshi, T. Owens, A. Nawrocki, M. Røssel Larsen, P. del Boccio, D.Pieragostino
Publicado en: Proteomic Forum EuPA Abstract Booklet, 2022
Editor: EuPA

Longitudinal evaluation of the therapeutic effect of APRIL in the Cuprizone mouse model of Multiple Sclerosis

Autores: Leonardo Ricciardi, Marion Decrop, Joëlle Van Rijswijk, Nicholas Vidas-Guscic, Julia Di Stefano, Tejaswini Kakunuri, Daniele Bertoglio, Bertrand Huard, Peter Ponsaerts, Marleen Verhoye
Publicado en: European Molecular Imaging Meeting-Programme, 2023, Página(s) Session PW14, poster 809
Editor: EMI

A drug repurposing study to enhance/target remyelination via the modulation of oligodendrocyte fate

Autores: Elif Nur Yılmaz, Raquel Guerrero González, Stefanie Albrecht, Tanja Kuhlmann
Publicado en: FENS Regional Meeting, 2023, Página(s) Session 1, Poster 14
Editor: FENS

Induction of inflammatory responses in bi- and tri-partite murine iPSC-derived neurospheroids

Autores: J. Di Stefano, E. Van Breedam, A. Quarta, J. Govaerts, L. Ricciardi, A. Silini3, O. Parolini, M. Verhoye, P. Ponsaerts
Publicado en: Glia, Edición Bi-annual, 2023, Página(s) T16-165C
Editor: Wiley
DOI: 10.1002/glia.24419

Molecular Mechanisms of Physiological and Pathophysiological Processes inMultiple Sclerosis-like Models Ex Vivo and In Vivo

Autores: Maurine Fucito
Publicado en: European Neuroscience Conference by Doctoral Students-Posters, 2021, Página(s) P6A25
Editor: FENS

Selective vulnerability of cortical neurons in rat in vitro and ex vivomodels of cortical Progressive Multiple Sclerosis pathology

Autores: Daniela Costa
Publicado en: 2021, Página(s) P6A12
Editor: FENS, BRAIN, BNA

Brain Proteomic Signatures of an in vivo Model of Multiple Sclerosis

Autores: M. Fucito, B. Ojha2, R. Khorooshi, T. Owens, A. Nawrocki, M. Røssel Larsen, P. del Boccio, D. Pieragostino
Publicado en: 2022, Página(s) 120
Editor: European Proteomics Association

DETERMINING THE IMPACT OF MOLECULAR CROWDING AGENTS ON DEPOSITION OF COLLAGEN BY CULTURED MENINGEAL CELLS

Autores: Małgorzata Dąbrowska, Meletios‑Nikolaos Doulgkeroglou, Jill Mary McMahon, Dimitrios Zeugolis, Una FitzGerald
Publicado en: Acta Neurobioligae Experimentalis, 2022, Página(s) 51, ISSN 1689-0035
Editor: Acta Neurobiologiae Experimentalis

Deciphering (Phospho)proteomics Brain and Spinal Cord Signatures of an in vivo Model of Multiple Sclerosis

Autores: Maurine Fucito
Publicado en: Human Proteome Organization World Congress-Programme, 2022, Página(s) PP03.026
Editor: Human Proteome Organisation

Defining selective neuronal vulnerabilities in human/rat tissue and hNPCs-derived cortical neurons in vitro model

Autores: Daniela AD Costa, Raquel Guerrero, Jill McMahon, Tanja Kuhlmann, Una FitzGerald
Publicado en: FENS Regional Meeting, Portugal- Programme, 2023, Página(s) Poster Session II, Number 149
Editor: FENS

Assessing the therapeutic potential of APRIL using in vivo MRI and in vitro Proteomics in the Cuprizone mouse model of Multiple Sclerosis

Autores: Leonardo Ricciardi, Federica Di Marco, Marion Decrop, Joëlle van Rijswijk, Julia Di Stefano, Nicholas Vidas-Guscic, Tejaswini Kakunuri, Bertrand Huard, Damiana Pieragostino, Peter Ponsaerts, Marleen Verhoye
Publicado en: European Molecular Imaging Meeting-Programme, 2023, Página(s) PS21-05
Editor: EMIM

Hyaluronic acid-based devices for transcranial drug delivery to tackleneurodegenerative diseases

Autores: M. Al-waeel, L. Ricciard, P. Ponsaerts, M. Verhoye3 U. Fitzgerald, A. Pandit
Publicado en: Glia, Edición Annual, 2023, Página(s) E5-E181
Editor: Wiley
DOI: 10.1002/glia.24418

ROSTRAL-TO-CAUDAL INCREASE IN METABOLIC ACTIVITY OF CULTURED EX VIVO SLICES OF NEONATAL RAT BRAIN

Autores: Małgorzata Dąbrowska, Jill Mcmahon, Bertrand Huard, Una Fitzgerald
Publicado en: FENS Forum 2022, 2022, Página(s) 2733, Board number S03-329
Editor: FENS

In vitro and in vivo testing of candidate neuroprotective compounds to target neurodegeneration in multiple sclerosis (MS)

Autores: Raquel Guerrero González, Elif Nur Yilmaz, Stefanie Albrecht, Tanja Kuhlmann
Publicado en: 2023, Página(s) Poster Session 1, Poster 18
Editor: FENS

Peer reviewed articles (6)

Lack of strong innate immune reactivity renders macrophages alone unable to control productive Varicella-Zoster Virus infection in an isogenic human iPSC-derived neuronal co-culture model

Autores: Elise Van Breedam, Tamariche Buyle-Huybrecht, Jonas Govaerts, Pieter Meysman, Andrea Bours, Marlies Boeren, Julia Di Stefano, Thalissa Caers, Hans De Reu, Laura Dirkx, Jolien Schippers, Esther Bartholomeus, Marielle Lebrun, Catherine Sadzot-Delvaux, Paulina Rybakowska, Marta E Alarcón-Riquelme, Concepción Marañón, Kris Laukens, Peter Delputte, Benson Ogunjimi, Peter Ponsaerts
Publicado en: Frontiers in Immunology, 2023, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2023.1177245

Influx of T cells into corpus callosum increases axonal injury, but does not change the course of remyelination in toxic demyelination

Autores: Elif Nur Yilmaz, Stefanie Albrecht, Katharina Groll, Christian Thomas, Lutz Wallhorn, Martin Herold, Stephanie Hucke, Luisa Klotz, Tanja Kuhlmann
Publicado en: GLIA, Edición Volume71, Edición4, 2023, Página(s) 991-1001, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.24319

Targeting Signaling Pathway Downstream of RIG-I/MAVS in the CNS Stimulates Production of Endogenous Type I IFN and Suppresses EAE.

Autores: Anne K Kronborg Hansen, Magdalena Dubik, Joanna Marczynska, Bhavya Ojha, Estanislao Nistal-Villán, Gloria González Aseguinolaza, Dina S Arengoth, Trevor Owens, Reza Khorooshi
Publicado en: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911292

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Autores: Kieran Joyce, Georgina Targa Fabra, Yagmur Bozkurt, Abhay Pandit
Publicado en: Signal Transduction and Targeted Therapy, Edición 6/1, 2021, ISSN 2059-3635
Editor: Springer Nature
DOI: 10.1038/s41392-021-00512-8

Luminescent Human iPSC-Derived Neurospheroids Enable Modeling of Neurotoxicity After Oxygen–glucose Deprivation

Autores: Elise Van Breedam, Aleksandra Nijak, Tamariche Buyle-Huybrecht, Julia Di Stefano, Marlies Boeren, Jonas Govaerts, Alessandra Quarta, Tine Swartenbroekx, Eva Z. Jacobs, Björn Menten, Rik Gijsbers, Peter Delputte, Maaike Alaerts, Behrouz Hassannia, Bart Loeys, Zwi Berneman, Jean-Pierre Timmermans, Philippe G. Jorens, Tom Vanden Berghe, Erik Fransen, An Wouters, Winnok H. De Vos, Peter Ponsaerts.
Publicado en: Neurotherapeutics, 2022, ISSN 1933-7213
Editor: Elsevier BV
DOI: 10.1007/s13311-022-01212-z

Molecular Research in Multiple Sclerosis

Autores: Maurine Fucito and Damiana Pieragostino
Publicado en: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23052792