ENdoThelial macRophage Alliance In Neuroinflammation

Deliverables

Workshop Imaging Techniques in the Investigation of Brain Macrophages and Endothelial Cells
Awarding of doctoral degrees for all ESRs
Filling of all ESR positions
Workshop Mass Spectrometry Techniques in the Investigation of Brain Macrophages and Endothelial Cells
Plan for alumni programme
Final symposium
One outreach activity per ESR during the first year
One outreach activity per ESR during the third year
One outreach activity per ESR during the second year
Workshop Genetic Manipulation of Brain Macrophages and Endothelial Cells

Review article on modulation of endothelial function by macrophages
One first-author publication in a peer-reviewed journal per ESR

One firstauthor publication in a peerreviewed journal per ESR

Review article on endothelial checkpoints of macrophage function
Review article on endothelial-macrophage interaction as a drug target

Review article on endothelialmacrophage interaction as a drug target

Evaluation report of ENTRAIN disseminated

Publications

Of mice and men: opposing effects of nicotinamide riboside on skeletal muscle physiology at rest and during exercise

Author(s): Laís S. S. Ferreira, Evandro A. De-Souza
Published in: The journal of Physiology, Issue 01 March 2021, 2021, ISSN 0022-3751
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/jp281428

Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments

Author(s): Hélène Party, Cléo Dujarrier, Marie Hébert, Sophie Lenoir, Sara Martinez de Lizarrondo, Raphaël Delépée, Claudine Fauchon, Marie-Christine Bouton, Pauline Obiang, Olivier Godefroy, Etienne Save, Laurent Lecardeur, Joëlle Chabry, Denis Vivien, Véronique Agin
Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-019-0807-2

Blood–Brain Barrier and Neurodegenerative Diseases—Modeling with iPSC-Derived Brain Cells

Author(s): Ying-Chieh Wu, Tuuli-Maria Sonninen, Sanni Peltonen, Jari Koistinaho and Šárka Lehtonen
Published in: International Journal of Molecular Sciences, Issue Vol. 22, Issue 14, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22147710

Modeling ischemic stroke in a triculture neurovascular unit on-a-chip

Author(s): Nienke R. Wevers; Arya Lekshmi Nair; Tania M. Fowke; Maria Pontier; Dhanesh G. Kasi; Xandor M. Spijkers; Charlie Hallard; Gwenaëlle Rabussier; Remko van Vught; Paul Vulto; Helga E. de Vries; Henriëtte L. Lanz
Published in: Fluids and Barriers of the CNS, Issue 18, 2021, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-021-00294-9

Can We Treat Neurodegenerative Proteinopathies by Enhancing Protein Degradation?

Author(s): Simone Engelender; Leonidas Stefanis; Salvatore Oddo; Arianna Bellucci
Published in: Crossref, Issue Vol 37, No 7, 2022, Page(s) 1346-1359, ISSN 0885-3185
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mds.29058

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

Author(s): Eszter Tóth; Lilla Turiák; Tamás Visnovitz; Csaba Cserép; Anett Mázló; Barbara W Sódar; András Försönits; Gábor Petővári; Anna Sebestyén; Zsolt István Komlósi; László Drahos; Ágnes Kittel; György Nagy; Attila Bacsi; Adam Denes; Yong Song Gho; Katalin Szabó-Taylor; Edit I. Buzás
Published in: Journal of Extracellular Vesicles, Vol 10, Iss 11, Pp n/a-n/a (2021), Issue 14, 2021, ISSN 2001-3078
Publisher: Wiley
DOI: 10.1002/jev2.12140

Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs

Author(s): Mattia Gallizioli, Francesc Miró-Mur, Amaia Otxoa-de-Amezaga, Roger Cugota, Angélica Salas-Perdomo, Carles Justicia, Vanessa H. Brait, Francisca Ruiz-Jaén, Maria Arbaizar-Rovirosa, Jordi Pedragosa, Ester Bonfill-Teixidor, Mathias Gelderblom, Tim Magnus, Eva Cano, Carlos del Fresno, David Sancho, Anna M. Planas
Published in: Cell Reports, Issue 33/3, 2020, Page(s) 108291, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108291

Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer’s disease

Author(s): Taisia Rolova, Ying-Chieh Wu, Marja Koskuvi, Jenni Voutilainen, Tuuli-Maria Sonninen, Johanna Kuusisto, Markku Laakso, Riikka H. Hämäläinen, Jari Koistinaho, Šárka Lehtonen
Published in: Stem Cell Research, Issue 48, 2020, Page(s) 101968, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2020.101968

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions.

Author(s): Eszter Császár; Nikolett Lénárt; Csaba Cserép; Zsuzsanna Környei; Rebeka Fekete; Balázs Pósfai; Diána Balázsfi; Balázs Hangya; Anett D. Schwarcz; Eszter Szabadits; Dávid Szöllősi; Krisztián Szigeti; Domokos Máthé; Brian L. West; Katalin Sviatkó; Ana Rita Brás; Jean-Charles Mariani; Andrea Kliewer; Zsolt Lenkei; László Hricisák; Zoltán Benyó; Mária Baranyi; Beáta Sperlágh
Published in: Journal of Experimental Medicine, Issue 219 (3), 2022, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20211071

Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain—Brief Report

Author(s): Jan Wenzel, Dimitrios Spyropoulos, Julian Christopher Assmann, Mahtab Ahmad Khan, Ines Stölting, Beate Lembrich, Sara Kreißig, Dirk Andreas Ridder, Berend Isermann, Markus Schwaninger
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 40, 2020, Page(s) 2837–2844, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.315061

How COVID-19 affects microvessels in the brain

Author(s): Jan Wenzel, Markus Schwaninger
Published in: Brain, Issue Volume 145, Issue 7, July 2022, 2022, Page(s) 2242–2244, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awac211

Filling the gaps on stroke research: Focus on inflammation and immunity

Author(s): Damien Levard, Izaskun Buendia, Anastasia Lanquetin, Martina Glavan, Denis Vivien, Marina Rubio
Published in: Brain, Behavior, and Immunity, 2020, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2020.09.025

Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Author(s): Csaba Cserép, Balázs Pósfai, Ádám Dénes
Published in: Neuron, Issue 109, 20 January 2021, 2021, Page(s) 22-240, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.11.007

Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation

Author(s): Daniela C. Ivan, Kristina Carolin Berve, Sabrina Walthert, Gianni Monaco, Katharina Borst, Elisa Bouillet, Filipa Ferreira, Henry Lee, Jasmin Steudler, Thorsten Buch, Marco Prinz, Britta Engelhardt, Giuseppe Locatelli
Published in: Acto Neuropathologica Communications, Issue 11, Article number 35, 2023, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-023-01535-8

Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives

Author(s): Tizibt Ashine Bogale, Gaia Faustini, Francesca Longhena, Stefania Mitola, Marina Pizzi, Arianna Bellucci
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.611761

Integrating transcriptomic datasets across neurological disease identifies unique myeloid subpopulations driving disease-specific signatures

Author(s): Claire L Wishart, Alanna G Spiteri, Giuseppe Locatelli, Nicholas J C King
Published in: Glia, Issue 07 April 2023, 2023, Page(s) 904-925, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.24314

The SARS-CoV-2 main protease M-pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Author(s): Josephine Lampe; Jan Wenzel; Helge Müller-Fielitz; Kristin Müller; Raphael Schuster; Linlin Zhang; Marietta Zille; Markus Krohn; Ümit Özorhan; Yun Jiang; Vanessa Neve; Anke Fähnrich; Fabian Ott; Sonja Binder; Hauke Busch; Ludovic Collin; Roberto Villasenor; Olaf Jöhren; Hermann Altmeppen; Manolis Pasparakis; Ruben Nogueiras; Vincent Prevot; Rolf Hilgenfeld; Markus Glatzel; Markus Schwaninger
Published in: nature neuroscience, Issue 24, 2021, Page(s) 1522-1533, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-86988/v1

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

Author(s): Csaba Cserép, Balázs Pósfai, Nikolett Lénárt, Rebeka Fekete, Zsófia I. László, Zsolt Lele, Barbara Orsolits, Gábor Molnár, Steffanie Heindl, Anett D. Schwarcz, Katinka Ujvári, Zsuzsanna Környei, Krisztina Tóth, Eszter Szabadits, Beáta Sperlágh, Mária Baranyi, László Csiba, Tibor Hortobágyi, Zsófia Maglóczky, Bernadett Martinecz, Gábor Szabó, Ferenc Erdélyi, Róbert Szipőcs
Published in: Science, Issue 367/6477, 2020, Page(s) 528-537, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax6752

Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain

Author(s): C. Siret, M. van Lessen, J. Bavais, H. W. Jeong, S. K. Reddy Samawar, K. Kapupara, S. Wang, M. Simic, L. de Fabritus, A. Tchoghandjian, M. Fallet, H. Huang, S. Sarrazin, M. H. Sieweke, R. Stumm, L. Sorokin, R. H. Adams, S. Schulte-Merker, F. Kiefer & S. A. van de Pavert
Published in: Nature Communications, Issue 13, Article number: 7366, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35166-9

Circulating tPA contributes to neurovascular coupling by a mechanism involving the endothelial NMDA receptors

Author(s): Antoine Anfray, Antoine Drieu, Vincent Hingot, Yannick Hommet, Mervé Yetim, Marina Rubio, Thomas Deffieux, Mickael Tanter, Cyrille Orset, Denis Vivien
Published in: J Cereb Blood Flow Metab ., Issue Oct 2020;40(10), 2020, Page(s) 2038-2054, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x19883599

Neural cortical organoids from self-assembling human iPSC as a model to investigate neurotoxicity in brain ischemia

Author(s): Massimiliano De Paola, Francesca Pischiutta, Davide Comolli, Alessandro Mariani, Joe Kelk, Ilaria Lisi, Milica Cerovic, Stefano Fumagalli, Gianluigi Forloni, Elisa R Zanier
Published in: Journal of Cerebral Blodd Flow & Metabolism, Issue Vol. 43, Issue 5, 2023, Page(s) 680-693, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x231152023

tPA-NMDAR Signaling Blockade Reduces the Incidence of Intracerebral Aneurysms

Author(s): Estelle R. Louet; Martina Glavan; Cyrille Orset; Jerome Parcq; Daniel F. Hanley; Denis Vivien
Published in: Crossref, Issue 13, 2022, Page(s) 1005-1016, ISSN 1868-4483
Publisher: Springer Pub. Co.,
DOI: 10.1007/s12975-022-01004-9

Border-associated macrophages influence the endothelial response to brain ischemia

Author(s): Figuerola, Sara; Pedragosa, Jordi; Gallizioli, Mattia; Nova, Judit; Petegnief, Valérie; Planas, Anna M.
Published in: instname:, Issue 3, 2021
Publisher: (IIBB) Communicaciones congresos

Deliverables

Publications

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