ENdoThelial macRophage Alliance In Neuroinflammation

Informazioni relative al progetto

ENTRAIN

ID dell’accordo di sovvenzione: 813294

DOI

10.3030/813294

Progetto chiuso

Data della firma CE 7 Maggio 2019

Data di avvio 1 Maggio 2019

Data di completamento 30 Aprile 2023

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 664 173,96

Contributo UE

€ 3 664 173,96

Coordinato da

UNIVERSITAET zu LUEBECK
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (10)

Workshop Imaging Techniques in the Investigation of Brain Macrophages and Endothelial Cells
Awarding of doctoral degrees for all ESRs
Filling of all ESR positions
Workshop Mass Spectrometry Techniques in the Investigation of Brain Macrophages and Endothelial Cells
Plan for alumni programme
Final symposium
One outreach activity per ESR during the first year
One outreach activity per ESR during the third year
One outreach activity per ESR during the second year
Workshop Genetic Manipulation of Brain Macrophages and Endothelial Cells

Documents, reports (5)

Review article on modulation of endothelial function by macrophages
One first-author publication in a peer-reviewed journal per ESR

One firstauthor publication in a peerreviewed journal per ESR

Review article on endothelial checkpoints of macrophage function
Review article on endothelial-macrophage interaction as a drug target

Review article on endothelialmacrophage interaction as a drug target

Evaluation report of ENTRAIN disseminated

Pubblicazioni

Peer reviewed articles (22)

Of mice and men: opposing effects of nicotinamide riboside on skeletal muscle physiology at rest and during exercise

Autori: Laís S. S. Ferreira, Evandro A. De-Souza
Pubblicato in: The journal of Physiology, Numero 01 March 2021, 2021, ISSN 0022-3751
Editore: Blackwell Publishing Inc.
DOI: 10.1113/jp281428

Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments

Autori: Hélène Party, Cléo Dujarrier, Marie Hébert, Sophie Lenoir, Sara Martinez de Lizarrondo, Raphaël Delépée, Claudine Fauchon, Marie-Christine Bouton, Pauline Obiang, Olivier Godefroy, Etienne Save, Laurent Lecardeur, Joëlle Chabry, Denis Vivien, Véronique Agin
Pubblicato in: Acta Neuropathologica Communications, Numero 7/1, 2019, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-019-0807-2

Blood–Brain Barrier and Neurodegenerative Diseases—Modeling with iPSC-Derived Brain Cells

Autori: Ying-Chieh Wu, Tuuli-Maria Sonninen, Sanni Peltonen, Jari Koistinaho and Šárka Lehtonen
Pubblicato in: International Journal of Molecular Sciences, Numero Vol. 22, Numero 14, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22147710

Modeling ischemic stroke in a triculture neurovascular unit on-a-chip

Autori: Nienke R. Wevers; Arya Lekshmi Nair; Tania M. Fowke; Maria Pontier; Dhanesh G. Kasi; Xandor M. Spijkers; Charlie Hallard; Gwenaëlle Rabussier; Remko van Vught; Paul Vulto; Helga E. de Vries; Henriëtte L. Lanz
Pubblicato in: Fluids and Barriers of the CNS, Numero 18, 2021, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-021-00294-9

Can We Treat Neurodegenerative Proteinopathies by Enhancing Protein Degradation?

Autori: Simone Engelender; Leonidas Stefanis; Salvatore Oddo; Arianna Bellucci
Pubblicato in: Crossref, Numero Vol 37, No 7, 2022, Pagina/e 1346-1359, ISSN 0885-3185
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mds.29058

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

Autori: Eszter Tóth; Lilla Turiák; Tamás Visnovitz; Csaba Cserép; Anett Mázló; Barbara W Sódar; András Försönits; Gábor Petővári; Anna Sebestyén; Zsolt István Komlósi; László Drahos; Ágnes Kittel; György Nagy; Attila Bacsi; Adam Denes; Yong Song Gho; Katalin Szabó-Taylor; Edit I. Buzás
Pubblicato in: Journal of Extracellular Vesicles, Vol 10, Iss 11, Pp n/a-n/a (2021), Numero 14, 2021, ISSN 2001-3078
Editore: Wiley
DOI: 10.1002/jev2.12140

Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs

Autori: Mattia Gallizioli, Francesc Miró-Mur, Amaia Otxoa-de-Amezaga, Roger Cugota, Angélica Salas-Perdomo, Carles Justicia, Vanessa H. Brait, Francisca Ruiz-Jaén, Maria Arbaizar-Rovirosa, Jordi Pedragosa, Ester Bonfill-Teixidor, Mathias Gelderblom, Tim Magnus, Eva Cano, Carlos del Fresno, David Sancho, Anna M. Planas
Pubblicato in: Cell Reports, Numero 33/3, 2020, Pagina/e 108291, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108291

Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer’s disease

Autori: Taisia Rolova, Ying-Chieh Wu, Marja Koskuvi, Jenni Voutilainen, Tuuli-Maria Sonninen, Johanna Kuusisto, Markku Laakso, Riikka H. Hämäläinen, Jari Koistinaho, Šárka Lehtonen
Pubblicato in: Stem Cell Research, Numero 48, 2020, Pagina/e 101968, ISSN 1873-5061
Editore: Elsevier
DOI: 10.1016/j.scr.2020.101968

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions.

Autori: Eszter Császár; Nikolett Lénárt; Csaba Cserép; Zsuzsanna Környei; Rebeka Fekete; Balázs Pósfai; Diána Balázsfi; Balázs Hangya; Anett D. Schwarcz; Eszter Szabadits; Dávid Szöllősi; Krisztián Szigeti; Domokos Máthé; Brian L. West; Katalin Sviatkó; Ana Rita Brás; Jean-Charles Mariani; Andrea Kliewer; Zsolt Lenkei; László Hricisák; Zoltán Benyó; Mária Baranyi; Beáta Sperlágh
Pubblicato in: Journal of Experimental Medicine, Numero 219 (3), 2022, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20211071

Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain—Brief Report

Autori: Jan Wenzel, Dimitrios Spyropoulos, Julian Christopher Assmann, Mahtab Ahmad Khan, Ines Stölting, Beate Lembrich, Sara Kreißig, Dirk Andreas Ridder, Berend Isermann, Markus Schwaninger
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 40, 2020, Pagina/e 2837–2844, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.315061

How COVID-19 affects microvessels in the brain

Autori: Jan Wenzel, Markus Schwaninger
Pubblicato in: Brain, Numero Volume 145, Numero 7, July 2022, 2022, Pagina/e 2242–2244, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awac211

Filling the gaps on stroke research: Focus on inflammation and immunity

Autori: Damien Levard, Izaskun Buendia, Anastasia Lanquetin, Martina Glavan, Denis Vivien, Marina Rubio
Pubblicato in: Brain, Behavior, and Immunity, 2020, ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2020.09.025

Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Autori: Csaba Cserép, Balázs Pósfai, Ádám Dénes
Pubblicato in: Neuron, Numero 109, 20 January 2021, 2021, Pagina/e 22-240, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2020.11.007

Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation

Autori: Daniela C. Ivan, Kristina Carolin Berve, Sabrina Walthert, Gianni Monaco, Katharina Borst, Elisa Bouillet, Filipa Ferreira, Henry Lee, Jasmin Steudler, Thorsten Buch, Marco Prinz, Britta Engelhardt, Giuseppe Locatelli
Pubblicato in: Acto Neuropathologica Communications, Numero 11, Article number 35, 2023, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-023-01535-8

Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives

Autori: Tizibt Ashine Bogale, Gaia Faustini, Francesca Longhena, Stefania Mitola, Marina Pizzi, Arianna Bellucci
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.611761

Integrating transcriptomic datasets across neurological disease identifies unique myeloid subpopulations driving disease-specific signatures

Autori: Claire L Wishart, Alanna G Spiteri, Giuseppe Locatelli, Nicholas J C King
Pubblicato in: Glia, Numero 07 April 2023, 2023, Pagina/e 904-925, ISSN 0894-1491
Editore: John Wiley & Sons Inc.
DOI: 10.1002/glia.24314

The SARS-CoV-2 main protease M-pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Autori: Josephine Lampe; Jan Wenzel; Helge Müller-Fielitz; Kristin Müller; Raphael Schuster; Linlin Zhang; Marietta Zille; Markus Krohn; Ümit Özorhan; Yun Jiang; Vanessa Neve; Anke Fähnrich; Fabian Ott; Sonja Binder; Hauke Busch; Ludovic Collin; Roberto Villasenor; Olaf Jöhren; Hermann Altmeppen; Manolis Pasparakis; Ruben Nogueiras; Vincent Prevot; Rolf Hilgenfeld; Markus Glatzel; Markus Schwaninger
Pubblicato in: nature neuroscience, Numero 24, 2021, Pagina/e 1522-1533, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.21203/rs.3.rs-86988/v1

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

Autori: Csaba Cserép, Balázs Pósfai, Nikolett Lénárt, Rebeka Fekete, Zsófia I. László, Zsolt Lele, Barbara Orsolits, Gábor Molnár, Steffanie Heindl, Anett D. Schwarcz, Katinka Ujvári, Zsuzsanna Környei, Krisztina Tóth, Eszter Szabadits, Beáta Sperlágh, Mária Baranyi, László Csiba, Tibor Hortobágyi, Zsófia Maglóczky, Bernadett Martinecz, Gábor Szabó, Ferenc Erdélyi, Róbert Szipőcs
Pubblicato in: Science, Numero 367/6477, 2020, Pagina/e 528-537, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aax6752

Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain

Autori: C. Siret, M. van Lessen, J. Bavais, H. W. Jeong, S. K. Reddy Samawar, K. Kapupara, S. Wang, M. Simic, L. de Fabritus, A. Tchoghandjian, M. Fallet, H. Huang, S. Sarrazin, M. H. Sieweke, R. Stumm, L. Sorokin, R. H. Adams, S. Schulte-Merker, F. Kiefer & S. A. van de Pavert
Pubblicato in: Nature Communications, Numero 13, Article number: 7366, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-35166-9

Circulating tPA contributes to neurovascular coupling by a mechanism involving the endothelial NMDA receptors

Autori: Antoine Anfray, Antoine Drieu, Vincent Hingot, Yannick Hommet, Mervé Yetim, Marina Rubio, Thomas Deffieux, Mickael Tanter, Cyrille Orset, Denis Vivien
Pubblicato in: J Cereb Blood Flow Metab ., Numero Oct 2020;40(10), 2020, Pagina/e 2038-2054, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x19883599

Neural cortical organoids from self-assembling human iPSC as a model to investigate neurotoxicity in brain ischemia

Autori: Massimiliano De Paola, Francesca Pischiutta, Davide Comolli, Alessandro Mariani, Joe Kelk, Ilaria Lisi, Milica Cerovic, Stefano Fumagalli, Gianluigi Forloni, Elisa R Zanier
Pubblicato in: Journal of Cerebral Blodd Flow & Metabolism, Numero Vol. 43, Numero 5, 2023, Pagina/e 680-693, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x231152023

tPA-NMDAR Signaling Blockade Reduces the Incidence of Intracerebral Aneurysms

Autori: Estelle R. Louet; Martina Glavan; Cyrille Orset; Jerome Parcq; Daniel F. Hanley; Denis Vivien
Pubblicato in: Crossref, Numero 13, 2022, Pagina/e 1005-1016, ISSN 1868-4483
Editore: Springer Pub. Co.,
DOI: 10.1007/s12975-022-01004-9

Conference proceedings (1)

Border-associated macrophages influence the endothelial response to brain ischemia

Autori: Figuerola, Sara; Pedragosa, Jordi; Gallizioli, Mattia; Nova, Judit; Petegnief, Valérie; Planas, Anna M.
Pubblicato in: instname:, Numero 3, 2021
Editore: (IIBB) Communicaciones congresos