Thrombo-inflammation in cardiovascular disease

Project Information

TICARDIO

Grant agreement ID: 813409

DOI 10.3030/813409

Project closed

EC signature date 20 August 2018

Start date 1 April 2019

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 659 126,35

EU contribution € 3 659 126,35

Coordinated by

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany

Deliverables

Other (15)

2. Main outreach activity

Main outreach activities

1. TICARDIO conference

TICARDIO conferences

Dissemination plan
2. Training week

Training weeks with basic and advanced courses

Agreements on joint degrees

Administrative agreement to establish a joint Doctorate

4. Main outreach activity

Main outreach activities

2. TICARDIO conference

TICARDIO conferences

3. Main outreach activity

Main outreach activities

1. Main outreach activity

Main outreach activities

1. Training week

Training weeks with basic and advanced courses

PhD theses submitted

15 PhD theses submitted

Communication and outreach plan
Exploitation plan
ESRs selected and employed
3. TICARDIO conference

TICARDIO conferences

Websites, patent fillings, videos etc. (1)

TICARDIO website

Publications

Peer reviewed articles (30)

Properdin (factor P) as a new target cleaved by factor XIa: Intrinsic coagulation at the crossroads with inflammation

Author(s): Luo Q, Wenzel P
Published in: Res Pract Thromb Haemost., 2022, ISSN 2475-0379
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/rth2.12835

Molecular Proteomics and Signalling of Human Platelets in Health and Disease

Author(s): Huang J, Zhang P, Solari FA, Sickmann A, Garcia A, Jurk K, Heemskerk JWM
Published in: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22189860

Unsupervised clustering of venous thromboembolism patients by clinical features at presentation identifies novel endotypes that improve prognostic stratification

Author(s): Pallares Robles A, Ten Cate V, Lenz M, Schulz A, Prochaska JH, Rapp S, Koeck T, Leineweber K, Heitmeier S, Opitz CF, Held M, Espinola-Klein C, Lackner KJ, Münzel T, Konstantinides SV, Ten Cate-Hoek A, Ten Cate H, Wild PS.
Published in: Thrombosis Research, 2023, ISSN 0049-3848
Publisher: Pergamon Press
DOI: 10.1016/j.thromres.2023.04.023

Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease

Author(s): G. Baidildinova, A. Pallares Robles, V. ten Cate, B.M.M. Kremers, S. Heitmeier, H. ten Cate, B.M.E. Mees, H.M.H. Spronk, P.S. Wild, A.J. ten Cate-Hoek, K. Jurk.
Published in: Thromb. Res., 2023, ISSN 0049-3848
Publisher: Pergamon Press
DOI: 10.1016/j.thromres.2023.08.017

Deletion of endothelial leptin receptors in mice promotes diet-induced obesity

Author(s): Gogiraju R, Witzler C, Shahneh F, Hubert A, Renner L, Bochenek ML, Zifkos K, Becker C, Thati M, Schäfer K.
Published in: Sci Rep., 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-35281-7

Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism

Author(s): Vincent Ten Cate, Jürgen H. Prochaska, Andreas Schulz, Thomas Koeck, Alejandro Pallares Robles, Michael Lenz, Lisa Eggebrecht, Steffen Rapp, Marina Panova-Noeva, H. Ardeschir Ghofrani, F. Joachim Meyer, Christine Espinola-Klein, Karl J. Lackner, Matthias Michal, Alexander K. Schuster, Konstantin Strauch, Alexander M. Zink, Volker Laux, Stefan Heitmeier, Stavros V. Konstantinides, Thomas Münzel,
Published in: Blood, Issue 137/19, 2021, Page(s) 2681-2693, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019004571

Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease

Author(s): Gaukhar Baidildinova, Magdolna Nagy, Kerstin Jurk, Philipp S. Wild, Hugo ten Cate, Paola E. J. van der Meijden
Published in: Frontiers in Cardiovascular Medicine, Issue 8, 2021, ISSN 2297-055X
Publisher: Front. Cardiovasc. Med
DOI: 10.3389/fcvm.2021.684920

Autoantibodies against the chemokine receptor 3 predict cardiovascular risk

Author(s): Müller FS, Aherrahrou Z, Grasshoff H, Heidorn MW, Humrich JY, Johanson L, Aherrahrou R, Reinberger T, Schulz A, Ten Cate V, Robles AP, Koeck T, Rapp S, Lange T, Brachaczek L, Luebber F, Erdmann J, Heidecke H, Schulze-Forster K, Dechend R, Lackner KJ, Pfeiffer N, Ghaemi Kerahrodi J, Tüscher O, Schwarting A, Strauch K, Münzel T, Prochaska JH, Riemekasten G, Wild PS.
Published in: Eur Heart J., 2023, ISSN 1522-9645
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehad666

Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis

Author(s): Alejandro Pallares Robles; Vincent ten Cate; Andreas Schulz; Jürgen H. Prochaska; Steffen Rapp; Thomas Koeck; Marina Panova-Noeva; Stefan Heitmeier; Stephan Schwers; Kirsten Leineweber; Hans-Jürgen Seyfarth; Christian F. Opitz; Henri Spronk; Christine Espinola-Klein; Karl J. Lackner; Thomas Münzel; Miguel A. Andrade-Navarro; Stavros V. Konstantinides; Hugo ten Cate; Philipp S. Wild
Published in: Scientific Reports, Issue 20452322, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-13174-5

Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

Author(s): Akbalut C, Arisz R, Baaten C, Baildildinova G, Barakzie A, Bauersachs R, Ten Berg JM, van den Broek W, de Boer HC, Broker V, Buka R, Ten Cate H, Cate AT, De Luca C, De Simone I, Dignat-George F, Freson K, Gazzaniga G, van Gorp E, Habibi A, Henskens YMC, Iding AFJ, Khan A, Koenderink G, Konkoth A, Lacroix R, Lahiri T, Lam W, Lamerton R, Lorusso R, Luo Q, Maas C, McCarty OJT, van der Meijden P, Meij
Published in: Thrombosis and Haemostasis, 2023, ISSN 2567-689X
Publisher: Thieme
DOI: 10.1055/a-2052-9175

Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow

Author(s): Schönichen C, Montague SJ, Brouns SLN, Burston JJ, Cosemans JMEM, Jurk K, Kehrel BE, Koenen RR, Ní Áinle F, O'Donnell VB, Soehnlein O, Watson SP, Kuijpers MJE, Heemskerk JWM, Nagy M.
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2023, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.122.318767

The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets

Author(s): Stephanie Makhoul, Elena Kumm, Pengyu Zhang, Ulrich Walter, Kerstin Jurk
Published in: International Journal of Molecular Sciences, Issue 21/23, 2020, Page(s) 8939, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21238939

Clinical profile and outcome of isolated pulmonary embolism: a systematic review and meta-analysis

Author(s): Ten Cate V, Prochaska JH, Schulz A, Nagler M, Robles AP, Jurk K, Koeck T, Rapp S, Düber C, Münzel T, Konstantinides SV, Wild PS
Published in: EClinicalMedicine, 2023, ISSN 2589-5370
Publisher: The Lancet
DOI: 10.1016/j.eclinm.2023.101973

Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability

Author(s): van Gorp RH, Baaten CCFMJ, Habibi A, Jaminon AMG, Peeters FECM, Leenders P, Crijns HJGMC, Heemskerk JWM, Reutelingsperger CP, Spronk HM, Schurgers LJ
Published in: European Heart Journal Open, 2021, ISSN 2752-4191
Publisher: Oxford Academic
DOI: 10.1093/ehjopen/oeab017

Multifaceted role of extracellular vesicles in atherosclerosis

Author(s): Akhil Konkoth, Ronald Saraswat, Cléa Dubrou, Florence Sabatier, Aurélie S. Leroyer, Romaric Lacroix, Anne-Claire Duchez, Francoise Dignat-George
Published in: Atherosclerosis, Issue 319, 2021, Page(s) 121-131, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2020.11.006

Discovery of four plasmatic biomarkers potentially predicting cardiovascular outcome in peripheral artery disease

Author(s): Kremers BMM, Posma JN, Heitmeier S, Glunz J, Ten Cate H, Pallares Robles A, Daemen JHC, Ten Cate-Hoek AJ, Mees BME, Spronk HMH
Published in: Science Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-23260-3

Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets

Author(s): Zhang P, Solari FA, Heemskerk JWM, Kuijpers MJE, Sickmann A, Walter U, Jurk K.
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24097776

Emerging Roles of RNA 3′-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders

Author(s): Jamie Nourse, Stefano Spada, Sven Danckwardt
Published in: Biomolecules, Issue 10/6, 2020, Page(s) 915, ISSN 2218-273X
Publisher: Biomolecules
DOI: 10.3390/biom10060915

Exploring phenotypes of deep vein thrombosis in relation to clinical outcomes beyond recurrence

Author(s): Iding AFJ, Robles AP, Ten Cate V, Ten Cate H, Wild PS, Ten Cate-Hoek AJ
Published in: Journal of Thrombosis and Haemostasis, 2023, ISSN 1538-7933
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jtha.2023.01.025

Subtype-specific plasma signatures of platelet-related protein releasate in acute pulmonary embolism

Author(s): Baidildinova G, Ten Cate V, Nagler M, Panova-Noeva M, Rapp S, Köck T, Prochaska JH, Heitmeier S, Gerdes C, Schwers S, Konstantinides SV, Münzel T, Espinola-Klein C, Lackner KJ, Spronk HMN, Ten Cate H, van der Meijden PEJ, Leineweber K, Wild PS, Jurk K
Published in: Thrombosis Research, 2022, ISSN 0049-3848
Publisher: Pergamon Press
DOI: 10.1016/j.thromres.2022.10.005

Post-transcriptional control of haemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders

Author(s): Sven Danckwardt; David-Alexandre Trégouët; Elisabetta Castoldi
Published in: "Cardiovascular Research, 2023, ⟨10.1093/cvr/cvad046⟩", Issue 2, 2024, ISSN 1755-3245
Publisher: Oxford University Press
DOI: 10.1093/cvr/cvad046

from simple fragments to inflammation regulators

Author(s): Rory R Koenen
Published in: European Heart Journal, 44(8), 633 - 635. Oxford University Press, Issue 1, 2023, ISSN 1522-9645
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac705

Circulating microRNAs predict recurrence and death following venous thromboembolism

Author(s): Ten Cate V, Rapp S, Schulz A, Pallares Robles A, Jurk K, Koeck T, Espinola-Klein C, Halank M, Seyfarth HJ, Beutel ME, Schuster AK, Marini F, Hobohm L, Lankeit M, Lackner KJ, Ruf W, Münzel T, Andrade-Navarro MA, Prochaska JH, Konstantinides SV, Wild PS.
Published in: J Thromb Haemost, 2023, ISSN 1538-7933
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jtha.2023.07.010

Endothelium‐mediated regulation of platelet activation: Involvement of multiple protein kinases

Author(s): Isabella Provenzale; Fiorella A. Solari; Claudia Schönichen; Sanne L. N. Brouns; Delia I. Fernández; Marijke J. E. Kuijpers; Paola E. J. van der Meijden; Jonathan M. Gibbins; Albert Sickmann; Chris Jones; Johan W. M. Heemskerk
Published in: The FASEB journal, Issue 3, 2024, ISSN 1530-6860
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202300360rr

Off‐target effects of oral anticoagulants – vascular effects of vitamin K antagonist and non‐vitamin K antagonist oral anticoagulant dabigatran etexilate

Author(s): Rick H. Gorp, Ingrid Dijkgraaf, Vanessa Bröker, Matthias Bauwens, Peter Leenders, Danyel Jennen, Marc R. Dweck, Jan Bucerius, Jacco J. Briedé, Joanne Ryn, Vincent Brandenburg, Felix Mottaghy, Henri M. H. Spronk, Chris P. Reutelingsperger, Leon J. Schurgers
Published in: Journal of Thrombosis and Haemostasis, Issue 19/5, 2021, Page(s) 1348-1363, ISSN 1538-7933
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jth.15289

Translational insights into mechanisms underlying residual venous obstruction and the role of factor XI, P-selectin and GPVI in recurrent venous thromboembolism

Author(s): Iding AFJ, Kremers BMM, Nagy M, Robles AP, Ten Cate H, Spronk HMH, Ten Cate-Hoek AJ
Published in: Thrombosis Research, 2023, ISSN 0049-3848
Publisher: Pergamon Press
DOI: 10.1016/j.thromres.2022.11.023

Residual venous obstruction as an indicator of clinical outcomes following deep vein thrombosis: a management study

Author(s): Aaron F.J. Iding; Bram M.M. Kremers; Alejandro Pallares Robles; Hugo ten Cate; Arina ten Cate
Published in: Thrombosis and Haemostasis, Issue 1, 2023, ISSN 2567-689X
Publisher: Thieme
DOI: 10.1055/a-2059-4737

Predictive value for increased activated factor XI activity in acute venous thromboembolism

Author(s): Nagy M, Robles AP, Visser M, Koeck T, Ten Cate V, Ten Cate-Hoek AJ, Schwers S, Heitmeier S, Ten Cate H, Wild PS, Spronk HMH
Published in: Journal of Thrombosis and Haemostasis, 2023, ISSN 1538-7933
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jtha.2023.02.031

Extracellular Vesicles and Thrombosis: Update on the Clinical and Experimental Evidence

Author(s): Konstantinos Zifkos, Christophe Dubois, Katrin Schäfer
Published in: International Journal of Molecular Sciences, Issue 22/17, 2021, Page(s) 9317, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179317

The Bidirectional Link Between RNA Cleavage and Polyadenylation and Genome Stability: Recent Insights From a Systematic Screen

Author(s): Spada S, Luke B, Danckwardt S
Published in: frontiers in Genetics, 2022, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2022.854907