Thrombo-inflammation in cardiovascular disease

Informacje na temat projektu

TICARDIO

Identyfikator umowy o grant: 813409

DOI

10.3030/813409

Projekt został zamknięty

Data podpisania przez KE 20 Sierpnia 2018

Data rozpoczęcia 1 Kwietnia 2019

Data zakończenia 30 Listopada 2023

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 3 659 126,35

Wkład UE

€ 3 659 126,35

Koordynowany przez

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Other (15)

2. Main outreach activity

Main outreach activities

1. TICARDIO conference

TICARDIO conferences

Dissemination plan
2. Training week

Training weeks with basic and advanced courses

Agreements on joint degrees

Administrative agreement to establish a joint Doctorate

4. Main outreach activity

Main outreach activities

2. TICARDIO conference

TICARDIO conferences

3. Main outreach activity

Main outreach activities

1. Main outreach activity

Main outreach activities

1. Training week

Training weeks with basic and advanced courses

PhD theses submitted

15 PhD theses submitted

Communication and outreach plan
Exploitation plan
ESRs selected and employed
3. TICARDIO conference

TICARDIO conferences

Websites, patent fillings, videos etc. (1)

TICARDIO website

Publikacje

Peer reviewed articles (37)

Properdin (factor P) as a new target cleaved by factor XIa: Intrinsic coagulation at the crossroads with inflammation

Autorzy: Luo Q, Wenzel P
Opublikowane w: Res Pract Thromb Haemost., 2022, ISSN 2475-0379
Wydawca: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/rth2.12835

Molecular Proteomics and Signalling of Human Platelets in Health and Disease

Autorzy: Huang J, Zhang P, Solari FA, Sickmann A, Garcia A, Jurk K, Heemskerk JWM
Opublikowane w: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22189860

Unsupervised clustering of venous thromboembolism patients by clinical features at presentation identifies novel endotypes that improve prognostic stratification

Autorzy: Pallares Robles A, Ten Cate V, Lenz M, Schulz A, Prochaska JH, Rapp S, Koeck T, Leineweber K, Heitmeier S, Opitz CF, Held M, Espinola-Klein C, Lackner KJ, Münzel T, Konstantinides SV, Ten Cate-Hoek A, Ten Cate H, Wild PS.
Opublikowane w: Thrombosis Research, 2023, ISSN 0049-3848
Wydawca: Pergamon Press
DOI: 10.1016/j.thromres.2023.04.023

Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease

Autorzy: G. Baidildinova, A. Pallares Robles, V. ten Cate, B.M.M. Kremers, S. Heitmeier, H. ten Cate, B.M.E. Mees, H.M.H. Spronk, P.S. Wild, A.J. ten Cate-Hoek, K. Jurk.
Opublikowane w: Thromb. Res., 2023, ISSN 0049-3848
Wydawca: Pergamon Press
DOI: 10.1016/j.thromres.2023.08.017

Deletion of endothelial leptin receptors in mice promotes diet-induced obesity

Autorzy: Gogiraju R, Witzler C, Shahneh F, Hubert A, Renner L, Bochenek ML, Zifkos K, Becker C, Thati M, Schäfer K.
Opublikowane w: Sci Rep., 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-35281-7

Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism

Autorzy: Vincent Ten Cate, Jürgen H. Prochaska, Andreas Schulz, Thomas Koeck, Alejandro Pallares Robles, Michael Lenz, Lisa Eggebrecht, Steffen Rapp, Marina Panova-Noeva, H. Ardeschir Ghofrani, F. Joachim Meyer, Christine Espinola-Klein, Karl J. Lackner, Matthias Michal, Alexander K. Schuster, Konstantin Strauch, Alexander M. Zink, Volker Laux, Stefan Heitmeier, Stavros V. Konstantinides, Thomas Münzel,
Opublikowane w: Blood, Numer 137/19, 2021, Strona(/y) 2681-2693, ISSN 0006-4971
Wydawca: American Society of Hematology
DOI: 10.1182/blood.2019004571

Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease

Autorzy: Gaukhar Baidildinova, Magdolna Nagy, Kerstin Jurk, Philipp S. Wild, Hugo ten Cate, Paola E. J. van der Meijden
Opublikowane w: Frontiers in Cardiovascular Medicine, Numer 8, 2021, ISSN 2297-055X
Wydawca: Front. Cardiovasc. Med
DOI: 10.3389/fcvm.2021.684920

Fundamental considerations for designing endothelialized in vitro models of thrombosis

Autorzy: Lemmens TP, Bröker V, Rijpkema M, Hughes CCW, Schurgers LJ, Cosemans JMEM
Opublikowane w: Thromb Res, 2024, ISSN 1879-2472
Wydawca: Elsevier
DOI: 10.1016/j.thromres.2024.03.004

Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis

Autorzy: Alejandro Pallares Robles; Vincent ten Cate; Andreas Schulz; Jürgen H. Prochaska; Steffen Rapp; Thomas Koeck; Marina Panova-Noeva; Stefan Heitmeier; Stephan Schwers; Kirsten Leineweber; Hans-Jürgen Seyfarth; Christian F. Opitz; Henri Spronk; Christine Espinola-Klein; Karl J. Lackner; Thomas Münzel; Miguel A. Andrade-Navarro; Stavros V. Konstantinides; Hugo ten Cate; Philipp S. Wild
Opublikowane w: Scientific Reports, Numer 1, 2022, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-13174-5

Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

Autorzy: Akbalut C, Arisz R, Baaten C, Baildildinova G, Barakzie A, Bauersachs R, Ten Berg JM, van den Broek W, de Boer HC, Broker V, Buka R, Ten Cate H, Cate AT, De Luca C, De Simone I, Dignat-George F, Freson K, Gazzaniga G, van Gorp E, Habibi A, Henskens YMC, Iding AFJ, Khan A, Koenderink G, Konkoth A, Lacroix R, Lahiri T, Lam W, Lamerton R, Lorusso R, Luo Q, Maas C, McCarty OJT, van der Meijden P, Meij
Opublikowane w: Thrombosis and Haemostasis, 2023, ISSN 2567-689X
Wydawca: Thieme
DOI: 10.1055/a-2052-9175

Macrophage-Expressed Coagulation Factor VII Promotes Adverse Cardiac Remodeling

Autorzy: Venkata Garlapati, Qi Luo, Jens Posma, Melania Aluia, Than Son Nguyen, Kristin Grunz, Michael Molitor, Stefanie Finger, Gregory Harms, Tobias Bopp, Wolfram Ruf, Philip Wenzel
Opublikowane w: Circulation Research, Numer 135, 2024, Strona(/y) 841-855, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.123.324114

Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow

Autorzy: Schönichen C, Montague SJ, Brouns SLN, Burston JJ, Cosemans JMEM, Jurk K, Kehrel BE, Koenen RR, Ní Áinle F, O'Donnell VB, Soehnlein O, Watson SP, Kuijpers MJE, Heemskerk JWM, Nagy M.
Opublikowane w: Arteriosclerosis, Thrombosis, and Vascular Biology, 2023, ISSN 1079-5642
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.122.318767

The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets

Autorzy: Stephanie Makhoul, Elena Kumm, Pengyu Zhang, Ulrich Walter, Kerstin Jurk
Opublikowane w: International Journal of Molecular Sciences, Numer 21/23, 2020, Strona(/y) 8939, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21238939

Clinical profile and outcome of isolated pulmonary embolism: a systematic review and meta-analysis

Autorzy: Ten Cate V, Prochaska JH, Schulz A, Nagler M, Robles AP, Jurk K, Koeck T, Rapp S, Düber C, Münzel T, Konstantinides SV, Wild PS
Opublikowane w: EClinicalMedicine, 2023, ISSN 2589-5370
Wydawca: The Lancet
DOI: 10.1016/j.eclinm.2023.101973

Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability

Autorzy: van Gorp RH, Baaten CCFMJ, Habibi A, Jaminon AMG, Peeters FECM, Leenders P, Crijns HJGMC, Heemskerk JWM, Reutelingsperger CP, Spronk HM, Schurgers LJ
Opublikowane w: European Heart Journal Open, 2021, ISSN 2752-4191
Wydawca: Oxford Academic
DOI: 10.1093/ehjopen/oeab017

Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation

Autorzy: Pengyu Zhang, Saskia von Ungern-Sternberg, Luisa Hastenplug, Fiorella A. Solari, Albert Sickmann, Marijke J. E. Kuijpers, Johan W. M. Heemskerk, Ulrich Walter, Kerstin Jurk
Opublikowane w: Thrombosis and Haemostasis, 2024, ISSN 0340-6245
Wydawca: Schattauer
DOI: 10.1055/a-2311-0117

Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation

Autorzy: Konstantinos Zifkos, Magdalena L. Bochenek, Rajinikanth Gogiraju, Stéphane Robert, Denise Pedrosa, Klytaimnistra Kiouptsi, Kateryna Moiko, Mathias Wagner, Felix Mahfoud, Philippe Poncelet, Thomas Münzel, Wolfram Ruf, Christoph Reinhardt, Laurence Panicot-Dubois, Christophe Dubois, Katrin Schäfer
Opublikowane w: Circulation Research, Numer 134, 2024, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.124.324214

Multifaceted role of extracellular vesicles in atherosclerosis

Autorzy: Akhil Konkoth, Ronald Saraswat, Cléa Dubrou, Florence Sabatier, Aurélie S. Leroyer, Romaric Lacroix, Anne-Claire Duchez, Francoise Dignat-George
Opublikowane w: Atherosclerosis, Numer 319, 2021, Strona(/y) 121-131, ISSN 0021-9150
Wydawca: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2020.11.006

Discovery of four plasmatic biomarkers potentially predicting cardiovascular outcome in peripheral artery disease

Autorzy: Kremers BMM, Posma JN, Heitmeier S, Glunz J, Ten Cate H, Pallares Robles A, Daemen JHC, Ten Cate-Hoek AJ, Mees BME, Spronk HMH
Opublikowane w: Science Reports, 2022, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-23260-3

Cardiovascular and genetic determinants of platelet high responsiveness: results from the Gutenberg Health Study

Autorzy: Gaukhar Baidildinova, Vincent ten Cate, Marina Panova-Noeva, Bianca Dahlen, Alexander Gieswinkel, Saskia von Ungern-Sternberg, Steffen Rapp, Konstantin Strauch, Manfred E. Beutel, Norbert Pfeiffer, Karl J. Lackner, Thomas Münzel, Hugo ten Cate, Philipp S. Wild, Kerstin Jurk
Opublikowane w: Blood Advances, Numer 8, 2024, Strona(/y) 3870-3874, ISSN 2473-9529
Wydawca: Science Direct
DOI: 10.1182/bloodadvances.2023012538

Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets

Autorzy: Zhang P, Solari FA, Heemskerk JWM, Kuijpers MJE, Sickmann A, Walter U, Jurk K.
Opublikowane w: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24097776

Exploring phenotypes of deep vein thrombosis in relation to clinical outcomes beyond recurrence

Autorzy: Iding AFJ, Robles AP, Ten Cate V, Ten Cate H, Wild PS, Ten Cate-Hoek AJ
Opublikowane w: Journal of Thrombosis and Haemostasis, 2023, ISSN 1538-7933
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.jtha.2023.01.025

Subtype-specific plasma signatures of platelet-related protein releasate in acute pulmonary embolism

Autorzy: Baidildinova G, Ten Cate V, Nagler M, Panova-Noeva M, Rapp S, Köck T, Prochaska JH, Heitmeier S, Gerdes C, Schwers S, Konstantinides SV, Münzel T, Espinola-Klein C, Lackner KJ, Spronk HMN, Ten Cate H, van der Meijden PEJ, Leineweber K, Wild PS, Jurk K
Opublikowane w: Thrombosis Research, 2022, ISSN 0049-3848
Wydawca: Pergamon Press
DOI: 10.1016/j.thromres.2022.10.005

Post-transcriptional control of haemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders

Autorzy: Sven Danckwardt; David-Alexandre Trégouët; Elisabetta Castoldi
Opublikowane w: "Cardiovascular Research, 2023, ⟨10.1093/cvr/cvad046⟩", Numer 2, 2024, ISSN 1755-3245
Wydawca: Oxford University Press
DOI: 10.1093/cvr/cvad046

from simple fragments to inflammation regulators

Autorzy: Rory R Koenen
Opublikowane w: European Heart Journal, 44(8), 633 - 635. Oxford University Press, Numer 1, 2023, ISSN 1522-9645
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehac705

Circulating microRNAs predict recurrence and death following venous thromboembolism

Autorzy: Ten Cate V, Rapp S, Schulz A, Pallares Robles A, Jurk K, Koeck T, Espinola-Klein C, Halank M, Seyfarth HJ, Beutel ME, Schuster AK, Marini F, Hobohm L, Lankeit M, Lackner KJ, Ruf W, Münzel T, Andrade-Navarro MA, Prochaska JH, Konstantinides SV, Wild PS.
Opublikowane w: J Thromb Haemost, 2023, ISSN 1538-7933
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.jtha.2023.07.010

Plasma levels of complement components C5 and C9 are associated with thrombin generation

Autorzy: Rocío Vacik Díaz, Gaëlle Munsch, Maria Jesus Iglesias, Alejandro Pallares Robles, Manal Ibrahim-Kosta, Jamie Nourse, Essak Khan, Elisabetta Castoldi, Noémie Saut, Anne Boland, Marine Germain, Jean-François Deleuze, Jacob Odeberg, Pierre-Emmanuel Morange, Sven Danckwardt, David-Alexandre Tregouët, Louisa Goumidi
Opublikowane w: Journal of Thrombosis and Haemostasis, Numer 22, 2024, Strona(/y) 2531-2542, ISSN 1538-7836
Wydawca: Elsevier
DOI: 10.1016/j.jtha.2024.04.026

Factor V variants in bleeding and thrombosis

Autorzy: Mohapatra AK, Todaro AM, Castoldi E.
Opublikowane w: Res Pract Thromb Haemost., 2024, ISSN 2475-0379
Wydawca: Elsevier

Endothelium‐mediated regulation of platelet activation: Involvement of multiple protein kinases

Autorzy: Isabella Provenzale; Fiorella A. Solari; Claudia Schönichen; Sanne L. N. Brouns; Delia I. Fernández; Marijke J. E. Kuijpers; Paola E. J. van der Meijden; Jonathan M. Gibbins; Albert Sickmann; Chris Jones; Johan W. M. Heemskerk
Opublikowane w: The FASEB journal, Numer 3, 2024, ISSN 1530-6860
Wydawca: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202300360rr

Off‐target effects of oral anticoagulants – vascular effects of vitamin K antagonist and non‐vitamin K antagonist oral anticoagulant dabigatran etexilate

Autorzy: Rick H. Gorp, Ingrid Dijkgraaf, Vanessa Bröker, Matthias Bauwens, Peter Leenders, Danyel Jennen, Marc R. Dweck, Jan Bucerius, Jacco J. Briedé, Joanne Ryn, Vincent Brandenburg, Felix Mottaghy, Henri M. H. Spronk, Chris P. Reutelingsperger, Leon J. Schurgers
Opublikowane w: Journal of Thrombosis and Haemostasis, Numer 19/5, 2021, Strona(/y) 1348-1363, ISSN 1538-7933
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/jth.15289

Translational insights into mechanisms underlying residual venous obstruction and the role of factor XI, P-selectin and GPVI in recurrent venous thromboembolism

Autorzy: Iding AFJ, Kremers BMM, Nagy M, Robles AP, Ten Cate H, Spronk HMH, Ten Cate-Hoek AJ
Opublikowane w: Thrombosis Research, 2023, ISSN 0049-3848
Wydawca: Pergamon Press
DOI: 10.1016/j.thromres.2022.11.023

Functionally distinct anticoagulant mechanisms of endothelial cells

Autorzy: Claudia Schönichen, Siyu Sun, Harmen Middelveld, Dana Huskens, Philip G. de Groot, Johan W.M. Heemskerk, Mark Roest, Bas de Laat
Opublikowane w: Thrombosis Research, Numer 244, 2024, Strona(/y) 109208, ISSN 0049-3848
Wydawca: Pergamon Press
DOI: 10.1016/j.thromres.2024.109208

Residual venous obstruction as an indicator of clinical outcomes following deep vein thrombosis: a management study

Autorzy: Aaron F.J. Iding; Bram M.M. Kremers; Alejandro Pallares Robles; Hugo ten Cate; Arina ten Cate
Opublikowane w: Thrombosis and Haemostasis, Numer 1, 2023, ISSN 2567-689X
Wydawca: Thieme
DOI: 10.1055/a-2059-4737

Predictive value for increased activated factor XI activity in acute venous thromboembolism

Autorzy: Nagy M, Robles AP, Visser M, Koeck T, Ten Cate V, Ten Cate-Hoek AJ, Schwers S, Heitmeier S, Ten Cate H, Wild PS, Spronk HMH
Opublikowane w: Journal of Thrombosis and Haemostasis, 2023, ISSN 1538-7933
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.jtha.2023.02.031

Extracellular Vesicles and Thrombosis: Update on the Clinical and Experimental Evidence

Autorzy: Konstantinos Zifkos, Christophe Dubois, Katrin Schäfer
Opublikowane w: International Journal of Molecular Sciences, Numer 22/17, 2021, Strona(/y) 9317, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179317

Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation

Autorzy: Tanja Knopp, Rebecca Jung, Johannes Wild, Magdalena L Bochenek, Panagiotis Efentakis, Annika Lehmann, Tabea Bieler, Venkata Garlapati, Cindy Richter, Michael Molitor, Katharina Perius, Stefanie Finger, Jérémy Lagrange, Iman Ghasemi, Konstantinos Zifkos, Katharina S Kommoss, Joumana Masri, Sonja Reißig, Voahanginirina Randriamboavonjy, Thomas Wunderlich, Nadine Hövelmeyer, Alexander N R Weber,
Opublikowane w: European Heart Journal Open, Numer 4, 2024, ISSN 2752-4191
Wydawca: Oxford University Press
DOI: 10.1093/ehjopen/oeae046

The Bidirectional Link Between RNA Cleavage and Polyadenylation and Genome Stability: Recent Insights From a Systematic Screen

Autorzy: Spada S, Luke B, Danckwardt S
Opublikowane w: frontiers in Genetics, 2022, ISSN 1664-8021
Wydawca: Frontiers Media
DOI: 10.3389/fgene.2022.854907