Thrombo-inflammation in cardiovascular disease

Informazioni relative al progetto

TICARDIO

ID dell’accordo di sovvenzione: 813409

DOI

10.3030/813409

Progetto chiuso

Data della firma CE 20 Agosto 2018

Data di avvio 1 Aprile 2019

Data di completamento 30 Novembre 2023

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 659 126,35

Contributo UE

€ 3 659 126,35

Coordinato da

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (15)

2. Main outreach activity

Main outreach activities

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TICARDIO conferences

Dissemination plan
2. Training week

Training weeks with basic and advanced courses

Agreements on joint degrees

Administrative agreement to establish a joint Doctorate

4. Main outreach activity

Main outreach activities

2. TICARDIO conference

TICARDIO conferences

3. Main outreach activity

Main outreach activities

1. Main outreach activity

Main outreach activities

1. Training week

Training weeks with basic and advanced courses

PhD theses submitted

15 PhD theses submitted

Communication and outreach plan
Exploitation plan
ESRs selected and employed
3. TICARDIO conference

TICARDIO conferences

Websites, patent fillings, videos etc. (1)

TICARDIO website

Pubblicazioni

Peer reviewed articles (37)

Properdin (factor P) as a new target cleaved by factor XIa: Intrinsic coagulation at the crossroads with inflammation

Autori: Luo Q, Wenzel P
Pubblicato in: Res Pract Thromb Haemost., 2022, ISSN 2475-0379
Editore: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/rth2.12835

Molecular Proteomics and Signalling of Human Platelets in Health and Disease

Autori: Huang J, Zhang P, Solari FA, Sickmann A, Garcia A, Jurk K, Heemskerk JWM
Pubblicato in: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22189860

Unsupervised clustering of venous thromboembolism patients by clinical features at presentation identifies novel endotypes that improve prognostic stratification

Autori: Pallares Robles A, Ten Cate V, Lenz M, Schulz A, Prochaska JH, Rapp S, Koeck T, Leineweber K, Heitmeier S, Opitz CF, Held M, Espinola-Klein C, Lackner KJ, Münzel T, Konstantinides SV, Ten Cate-Hoek A, Ten Cate H, Wild PS.
Pubblicato in: Thrombosis Research, 2023, ISSN 0049-3848
Editore: Pergamon Press
DOI: 10.1016/j.thromres.2023.04.023

Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease

Autori: G. Baidildinova, A. Pallares Robles, V. ten Cate, B.M.M. Kremers, S. Heitmeier, H. ten Cate, B.M.E. Mees, H.M.H. Spronk, P.S. Wild, A.J. ten Cate-Hoek, K. Jurk.
Pubblicato in: Thromb. Res., 2023, ISSN 0049-3848
Editore: Pergamon Press
DOI: 10.1016/j.thromres.2023.08.017

Deletion of endothelial leptin receptors in mice promotes diet-induced obesity

Autori: Gogiraju R, Witzler C, Shahneh F, Hubert A, Renner L, Bochenek ML, Zifkos K, Becker C, Thati M, Schäfer K.
Pubblicato in: Sci Rep., 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-35281-7

Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism

Autori: Vincent Ten Cate, Jürgen H. Prochaska, Andreas Schulz, Thomas Koeck, Alejandro Pallares Robles, Michael Lenz, Lisa Eggebrecht, Steffen Rapp, Marina Panova-Noeva, H. Ardeschir Ghofrani, F. Joachim Meyer, Christine Espinola-Klein, Karl J. Lackner, Matthias Michal, Alexander K. Schuster, Konstantin Strauch, Alexander M. Zink, Volker Laux, Stefan Heitmeier, Stavros V. Konstantinides, Thomas Münzel,
Pubblicato in: Blood, Numero 137/19, 2021, Pagina/e 2681-2693, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019004571

Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease

Autori: Gaukhar Baidildinova, Magdolna Nagy, Kerstin Jurk, Philipp S. Wild, Hugo ten Cate, Paola E. J. van der Meijden
Pubblicato in: Frontiers in Cardiovascular Medicine, Numero 8, 2021, ISSN 2297-055X
Editore: Front. Cardiovasc. Med
DOI: 10.3389/fcvm.2021.684920

Fundamental considerations for designing endothelialized in vitro models of thrombosis

Autori: Lemmens TP, Bröker V, Rijpkema M, Hughes CCW, Schurgers LJ, Cosemans JMEM
Pubblicato in: Thromb Res, 2024, ISSN 1879-2472
Editore: Elsevier
DOI: 10.1016/j.thromres.2024.03.004

Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis

Autori: Alejandro Pallares Robles; Vincent ten Cate; Andreas Schulz; Jürgen H. Prochaska; Steffen Rapp; Thomas Koeck; Marina Panova-Noeva; Stefan Heitmeier; Stephan Schwers; Kirsten Leineweber; Hans-Jürgen Seyfarth; Christian F. Opitz; Henri Spronk; Christine Espinola-Klein; Karl J. Lackner; Thomas Münzel; Miguel A. Andrade-Navarro; Stavros V. Konstantinides; Hugo ten Cate; Philipp S. Wild
Pubblicato in: Scientific Reports, Numero 1, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-13174-5

Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

Autori: Akbalut C, Arisz R, Baaten C, Baildildinova G, Barakzie A, Bauersachs R, Ten Berg JM, van den Broek W, de Boer HC, Broker V, Buka R, Ten Cate H, Cate AT, De Luca C, De Simone I, Dignat-George F, Freson K, Gazzaniga G, van Gorp E, Habibi A, Henskens YMC, Iding AFJ, Khan A, Koenderink G, Konkoth A, Lacroix R, Lahiri T, Lam W, Lamerton R, Lorusso R, Luo Q, Maas C, McCarty OJT, van der Meijden P, Meij
Pubblicato in: Thrombosis and Haemostasis, 2023, ISSN 2567-689X
Editore: Thieme
DOI: 10.1055/a-2052-9175

Macrophage-Expressed Coagulation Factor VII Promotes Adverse Cardiac Remodeling

Autori: Venkata Garlapati, Qi Luo, Jens Posma, Melania Aluia, Than Son Nguyen, Kristin Grunz, Michael Molitor, Stefanie Finger, Gregory Harms, Tobias Bopp, Wolfram Ruf, Philip Wenzel
Pubblicato in: Circulation Research, Numero 135, 2024, Pagina/e 841-855, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.123.324114

Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow

Autori: Schönichen C, Montague SJ, Brouns SLN, Burston JJ, Cosemans JMEM, Jurk K, Kehrel BE, Koenen RR, Ní Áinle F, O'Donnell VB, Soehnlein O, Watson SP, Kuijpers MJE, Heemskerk JWM, Nagy M.
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2023, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.122.318767

The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets

Autori: Stephanie Makhoul, Elena Kumm, Pengyu Zhang, Ulrich Walter, Kerstin Jurk
Pubblicato in: International Journal of Molecular Sciences, Numero 21/23, 2020, Pagina/e 8939, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21238939

Clinical profile and outcome of isolated pulmonary embolism: a systematic review and meta-analysis

Autori: Ten Cate V, Prochaska JH, Schulz A, Nagler M, Robles AP, Jurk K, Koeck T, Rapp S, Düber C, Münzel T, Konstantinides SV, Wild PS
Pubblicato in: EClinicalMedicine, 2023, ISSN 2589-5370
Editore: The Lancet
DOI: 10.1016/j.eclinm.2023.101973

Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability

Autori: van Gorp RH, Baaten CCFMJ, Habibi A, Jaminon AMG, Peeters FECM, Leenders P, Crijns HJGMC, Heemskerk JWM, Reutelingsperger CP, Spronk HM, Schurgers LJ
Pubblicato in: European Heart Journal Open, 2021, ISSN 2752-4191
Editore: Oxford Academic
DOI: 10.1093/ehjopen/oeab017

Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation

Autori: Pengyu Zhang, Saskia von Ungern-Sternberg, Luisa Hastenplug, Fiorella A. Solari, Albert Sickmann, Marijke J. E. Kuijpers, Johan W. M. Heemskerk, Ulrich Walter, Kerstin Jurk
Pubblicato in: Thrombosis and Haemostasis, 2024, ISSN 0340-6245
Editore: Schattauer
DOI: 10.1055/a-2311-0117

Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation

Autori: Konstantinos Zifkos, Magdalena L. Bochenek, Rajinikanth Gogiraju, Stéphane Robert, Denise Pedrosa, Klytaimnistra Kiouptsi, Kateryna Moiko, Mathias Wagner, Felix Mahfoud, Philippe Poncelet, Thomas Münzel, Wolfram Ruf, Christoph Reinhardt, Laurence Panicot-Dubois, Christophe Dubois, Katrin Schäfer
Pubblicato in: Circulation Research, Numero 134, 2024, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.124.324214

Multifaceted role of extracellular vesicles in atherosclerosis

Autori: Akhil Konkoth, Ronald Saraswat, Cléa Dubrou, Florence Sabatier, Aurélie S. Leroyer, Romaric Lacroix, Anne-Claire Duchez, Francoise Dignat-George
Pubblicato in: Atherosclerosis, Numero 319, 2021, Pagina/e 121-131, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2020.11.006

Discovery of four plasmatic biomarkers potentially predicting cardiovascular outcome in peripheral artery disease

Autori: Kremers BMM, Posma JN, Heitmeier S, Glunz J, Ten Cate H, Pallares Robles A, Daemen JHC, Ten Cate-Hoek AJ, Mees BME, Spronk HMH
Pubblicato in: Science Reports, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-23260-3

Cardiovascular and genetic determinants of platelet high responsiveness: results from the Gutenberg Health Study

Autori: Gaukhar Baidildinova, Vincent ten Cate, Marina Panova-Noeva, Bianca Dahlen, Alexander Gieswinkel, Saskia von Ungern-Sternberg, Steffen Rapp, Konstantin Strauch, Manfred E. Beutel, Norbert Pfeiffer, Karl J. Lackner, Thomas Münzel, Hugo ten Cate, Philipp S. Wild, Kerstin Jurk
Pubblicato in: Blood Advances, Numero 8, 2024, Pagina/e 3870-3874, ISSN 2473-9529
Editore: Science Direct
DOI: 10.1182/bloodadvances.2023012538

Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets

Autori: Zhang P, Solari FA, Heemskerk JWM, Kuijpers MJE, Sickmann A, Walter U, Jurk K.
Pubblicato in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24097776

Exploring phenotypes of deep vein thrombosis in relation to clinical outcomes beyond recurrence

Autori: Iding AFJ, Robles AP, Ten Cate V, Ten Cate H, Wild PS, Ten Cate-Hoek AJ
Pubblicato in: Journal of Thrombosis and Haemostasis, 2023, ISSN 1538-7933
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jtha.2023.01.025

Subtype-specific plasma signatures of platelet-related protein releasate in acute pulmonary embolism

Autori: Baidildinova G, Ten Cate V, Nagler M, Panova-Noeva M, Rapp S, Köck T, Prochaska JH, Heitmeier S, Gerdes C, Schwers S, Konstantinides SV, Münzel T, Espinola-Klein C, Lackner KJ, Spronk HMN, Ten Cate H, van der Meijden PEJ, Leineweber K, Wild PS, Jurk K
Pubblicato in: Thrombosis Research, 2022, ISSN 0049-3848
Editore: Pergamon Press
DOI: 10.1016/j.thromres.2022.10.005

Post-transcriptional control of haemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders

Autori: Sven Danckwardt; David-Alexandre Trégouët; Elisabetta Castoldi
Pubblicato in: "Cardiovascular Research, 2023, ⟨10.1093/cvr/cvad046⟩", Numero 2, 2024, ISSN 1755-3245
Editore: Oxford University Press
DOI: 10.1093/cvr/cvad046

from simple fragments to inflammation regulators

Autori: Rory R Koenen
Pubblicato in: European Heart Journal, 44(8), 633 - 635. Oxford University Press, Numero 1, 2023, ISSN 1522-9645
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehac705

Circulating microRNAs predict recurrence and death following venous thromboembolism

Autori: Ten Cate V, Rapp S, Schulz A, Pallares Robles A, Jurk K, Koeck T, Espinola-Klein C, Halank M, Seyfarth HJ, Beutel ME, Schuster AK, Marini F, Hobohm L, Lankeit M, Lackner KJ, Ruf W, Münzel T, Andrade-Navarro MA, Prochaska JH, Konstantinides SV, Wild PS.
Pubblicato in: J Thromb Haemost, 2023, ISSN 1538-7933
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jtha.2023.07.010

Plasma levels of complement components C5 and C9 are associated with thrombin generation

Autori: Rocío Vacik Díaz, Gaëlle Munsch, Maria Jesus Iglesias, Alejandro Pallares Robles, Manal Ibrahim-Kosta, Jamie Nourse, Essak Khan, Elisabetta Castoldi, Noémie Saut, Anne Boland, Marine Germain, Jean-François Deleuze, Jacob Odeberg, Pierre-Emmanuel Morange, Sven Danckwardt, David-Alexandre Tregouët, Louisa Goumidi
Pubblicato in: Journal of Thrombosis and Haemostasis, Numero 22, 2024, Pagina/e 2531-2542, ISSN 1538-7836
Editore: Elsevier
DOI: 10.1016/j.jtha.2024.04.026

Factor V variants in bleeding and thrombosis

Autori: Mohapatra AK, Todaro AM, Castoldi E.
Pubblicato in: Res Pract Thromb Haemost., 2024, ISSN 2475-0379
Editore: Elsevier

Endothelium‐mediated regulation of platelet activation: Involvement of multiple protein kinases

Autori: Isabella Provenzale; Fiorella A. Solari; Claudia Schönichen; Sanne L. N. Brouns; Delia I. Fernández; Marijke J. E. Kuijpers; Paola E. J. van der Meijden; Jonathan M. Gibbins; Albert Sickmann; Chris Jones; Johan W. M. Heemskerk
Pubblicato in: The FASEB journal, Numero 3, 2024, ISSN 1530-6860
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202300360rr

Off‐target effects of oral anticoagulants – vascular effects of vitamin K antagonist and non‐vitamin K antagonist oral anticoagulant dabigatran etexilate

Autori: Rick H. Gorp, Ingrid Dijkgraaf, Vanessa Bröker, Matthias Bauwens, Peter Leenders, Danyel Jennen, Marc R. Dweck, Jan Bucerius, Jacco J. Briedé, Joanne Ryn, Vincent Brandenburg, Felix Mottaghy, Henri M. H. Spronk, Chris P. Reutelingsperger, Leon J. Schurgers
Pubblicato in: Journal of Thrombosis and Haemostasis, Numero 19/5, 2021, Pagina/e 1348-1363, ISSN 1538-7933
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jth.15289

Translational insights into mechanisms underlying residual venous obstruction and the role of factor XI, P-selectin and GPVI in recurrent venous thromboembolism

Autori: Iding AFJ, Kremers BMM, Nagy M, Robles AP, Ten Cate H, Spronk HMH, Ten Cate-Hoek AJ
Pubblicato in: Thrombosis Research, 2023, ISSN 0049-3848
Editore: Pergamon Press
DOI: 10.1016/j.thromres.2022.11.023

Functionally distinct anticoagulant mechanisms of endothelial cells

Autori: Claudia Schönichen, Siyu Sun, Harmen Middelveld, Dana Huskens, Philip G. de Groot, Johan W.M. Heemskerk, Mark Roest, Bas de Laat
Pubblicato in: Thrombosis Research, Numero 244, 2024, Pagina/e 109208, ISSN 0049-3848
Editore: Pergamon Press
DOI: 10.1016/j.thromres.2024.109208

Residual venous obstruction as an indicator of clinical outcomes following deep vein thrombosis: a management study

Autori: Aaron F.J. Iding; Bram M.M. Kremers; Alejandro Pallares Robles; Hugo ten Cate; Arina ten Cate
Pubblicato in: Thrombosis and Haemostasis, Numero 1, 2023, ISSN 2567-689X
Editore: Thieme
DOI: 10.1055/a-2059-4737

Predictive value for increased activated factor XI activity in acute venous thromboembolism

Autori: Nagy M, Robles AP, Visser M, Koeck T, Ten Cate V, Ten Cate-Hoek AJ, Schwers S, Heitmeier S, Ten Cate H, Wild PS, Spronk HMH
Pubblicato in: Journal of Thrombosis and Haemostasis, 2023, ISSN 1538-7933
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jtha.2023.02.031

Extracellular Vesicles and Thrombosis: Update on the Clinical and Experimental Evidence

Autori: Konstantinos Zifkos, Christophe Dubois, Katrin Schäfer
Pubblicato in: International Journal of Molecular Sciences, Numero 22/17, 2021, Pagina/e 9317, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179317

Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation

Autori: Tanja Knopp, Rebecca Jung, Johannes Wild, Magdalena L Bochenek, Panagiotis Efentakis, Annika Lehmann, Tabea Bieler, Venkata Garlapati, Cindy Richter, Michael Molitor, Katharina Perius, Stefanie Finger, Jérémy Lagrange, Iman Ghasemi, Konstantinos Zifkos, Katharina S Kommoss, Joumana Masri, Sonja Reißig, Voahanginirina Randriamboavonjy, Thomas Wunderlich, Nadine Hövelmeyer, Alexander N R Weber,
Pubblicato in: European Heart Journal Open, Numero 4, 2024, ISSN 2752-4191
Editore: Oxford University Press
DOI: 10.1093/ehjopen/oeae046

The Bidirectional Link Between RNA Cleavage and Polyadenylation and Genome Stability: Recent Insights From a Systematic Screen

Autori: Spada S, Luke B, Danckwardt S
Pubblicato in: frontiers in Genetics, 2022, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2022.854907