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TRAIN-HEART

Project description

Training the next generation of researchers in RNA therapeutics

Non-coding RNAs such as microRNAs and long non-coding RNAs serve as critical regulators of many biological processes including cardiac tissue remodelling after myocardial infarction. Despite the promise of RNA therapeutics, their success has been hampered by specificity and tolerability issues. The scope of the EU-funded TRAIN-HEART project is to train the next generation of research fellows to develop improved RNA-based therapeutics for the treatment of ischaemic heart failure. Through the establishment of a large consortium of academic and industrial partners, TRAIN-HEART will educate trainees on disease pathogenesis, the therapeutic potential of RNA molecules and novel drug delivery systems.

Objective

TRAIN-HEART brings together leading academic teams and (biotech) companies to train the next-generation of innovation-minded researchers who can expand the scientific horizons and accelerate future development of RNA-based therapeutics
for the treatment of ischemic heart failure. Under chronic cardiac stress, non-coding RNAs, in particular microRNAs and long
non-coding RNAs, act as critical regulators of cardiac tissue remodelling. Innovative therapies targeting these RNA
molecules hold great promise in treating the underlying causes of ischemic heart failure. With the exception of heart
transplantation, there is no curative therapy available for this detrimental disease. Given the challenges related to delivery,
specificity and tolerability of RNA therapeutics, developments in chemically modified oligonucleotides and drug delivery
strategies are growing substantially. TRAIN-HEART’s proposition is to train a league of 15 promising fellows that harness
novel insights in the pathogenesis of ischemic heart failure, study the therapeutic potential of existing RNA therapeutics and improve its efficacy by the design of novel drug delivery systems.
TRAIN-HEART provides such training in a European network of top-level academic teams and (biotech) companies active
in the fields of cardiovascular biology, functional genomics and drug development. All individual research projects
demonstrate multidisciplinary content and supervision arrangements, momentous intersectoral exchanges and
international synergies. These PhD programmes are complemented with the right combination of specialised research- and transferable skills trainings to encourage excellent science, innovation and long-term employability. The TRAIN-HEART
fellows are envisioned to become entrepreneurial researchers who are keen to bring cutting-edge scientific concepts in RNA
therapeutics to the clinic.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-ITN-2018

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Coordinator

UNIVERSITEIT MAASTRICHT
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 531 239,76
Address
MINDERBROEDERSBERG 4
6200 MD Maastricht
Netherlands

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Region
Zuid-Nederland Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 531 239,76

Participants (9)

Partners (6)

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