Description du projet
Des traitements régénératifs pour les maladies rénales
L’insuffisance rénale chronique se caractérise par une perte progressive de la fonction rénale, qui nécessite une dialyse ou, dans les cas extrêmes, une transplantation. Les progrès réalisés dans le domaine de la biologie des cellules souches permettent le développement de thérapies régénératives visant à réparer ou à remplacer les tissus rénaux endommagés. L’objectif du projet RenalToolBox, financé par l’UE, est de mettre au point des technologies permettant de faciliter la mise en œuvre en clinique de ces interventions régénératives à base de cellules. Le projet implique la formation pluridisciplinaire et multisectorielle de jeunes chercheurs dans les domaines de la thérapeutique cellulaire et de la médecine régénérative. Ces stagiaires développeront de nouveaux outils de diagnostic et se concentreront sur les thérapies reposant sur les cellules stromales mésenchymateuses.
Objectif
The RenalToolBox ITN comprises a team of world-leading clinicians, scientists and industrialists from academia and private enterprise whose common goal is to develop innovative medical devices and imaging technologies to expedite the translation of cell-based regenerative medicine therapies (RMTs) to the clinic. The target disease for RenalToolBox is kidney disease, the incidence of which is increasing annually. The ITN provides an excellent framework for training 15 early stage researchers (ESRs) in a range of technological, entrepreneurial and transferable skills that will not only enhance their career prospects, but will also boost European scientific excellence and business innovation. By the end of the programme, the ESRs will have benefitted from a comprehensive multidisciplinary and multi-sectoral training experience that will equip them to expedite progress in the emerging supradisciplinary fields of biomedical devices, bio-imaging, cellular therapeutics and regenerative medicine. The research training objectives are as follows: 1. Train the young researchers in the development of diagnostic devices and novel tracers for monitoring renal function. 2. Apply cutting-edge imaging technologies to evaluate the safety and efficacy of novel cell-based RMTs in a rodent model of kidney disease. 3. Assess the safety and efficacy of different sources of mesenchymal stromal cells and explore the mechanisms whereby these cells can ameliorate kidney disease. This comprehensive training programme will endow the young researchers with the necessary scientific and industrial skills to ensure their employability and readiness to engage and lead the next European generation of scientists-entrepreneurs.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
L69 7ZX Liverpool
Royaume-Uni