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A new generation of microbial expression hosts and tools for the production of biotherapeutics and high-value enzymes

Objective

The ‘SECRETERS’ partnership aims to bring about a step change in the production of recombinant proteins, particularly Biotherapeutics and Industrial Enzymes. Both are critical products for the EU biotechnology sector, with combined markets in excess of $140 billion p.a.; the former are essential for the treatment of major diseases whereas the latter permeate every aspect of our daily life. Many proteins in these categories pose severe problems in production, especially disulphide-bonded proteins and new format 'difficult-to-express' proteins. SECRETERS will train a team of 15 ESRs to develop a new generation of super-producing microbial production hosts, including Escherichia coli, Bacillus species and the yeast Pichia pastoris. The project capitalises on a series of recent innovations and involves close collaboration between 5 academic Beneficiaries, who provide world-leading expertise in redox chemistry, synthetic biology and protein expression, and 5 non-academic Beneficiaries, who include some of the world's premier biotherapeutic and industrial enzyme companies. It will enable the biotherapeutics industry to produce challenging medicines at lower costs, resulting in new drugs and wider patient access, and allow the enzymes industry to deliver a range of powerful new products. SECRETERS will equip ESRs with the interdisciplinary and intersectoral skills required to thrive in these industries, with quality assurance systems embedded throughout the programme and a commitment to a wide-ranging dissemination/outreach programme. Based on a responsible innovation approach, with clear foci on research and entrepreneurial training, SECRETERS will deliver a team of superbly-trained scientists, poised to engage in some of Europe's most important biotechnology sectors.

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Net EU contribution
€ 531 239,76
Address
Hanzeplein 1
9713 GZ Groningen
Netherlands

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (11)

UNIVERSITY OF KENT
United Kingdom
Net EU contribution
€ 606 345,12
Address
The Registry Canterbury
CT2 7NZ Canterbury, Kent

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Region
South East (England) Kent East Kent
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
OULUN YLIOPISTO
Finland
Net EU contribution
€ 561 611,52
Address
Pentti Kaiteran Katu 1
90014 Oulu

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAET GREIFSWALD
Germany
Net EU contribution
€ 252 788,40
Address
Domstrasse 11
17489 Greifswald

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
Net EU contribution
€ 252 788,40
Address
Unter Den Linden 6
10117 Berlin

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ACIB GMBH
Austria
Net EU contribution
€ 528 414,48
Address
Krenngasse 37/2
8010 Graz

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Region
Südösterreich Steiermark Graz
Activity type
Research Organisations
Non-EU contribution
€ 0,00
LONZA AG
Switzerland
Net EU contribution
€ 281 276,64
Address
Muenchensteinerstrasse 38
4002 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
AB ENZYMES GMBH
Germany
Net EU contribution
€ 252 788,40
Address
Feldbergstrasse 78
64293 Darmstadt

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Region
Darmstadt Darmstadt, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UCB Biopharma SPRL

Participation ended

Belgium
Net EU contribution
€ 0,00
Address
Allée De La Recherche
1070 Brussels

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
BOEHRINGER INGELHEIM RCV GMBH & CO KG
Austria
Net EU contribution
€ 264 207,24
Address
Dr Boehringer Gasse 5-11
1121 Wien

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Region
Wien Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITATSMEDIZIN GREIFSWALD KORPERSCHAFT DES OFFENTLICHEN RECHTS
Germany
Net EU contribution
€ 252 788,40
Address
Fleischmannstrasse 8
17489 Greifswald

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CELLTECH R&D LIMITED
United Kingdom
Net EU contribution
€ 303 172,56
Address
208 Bath Road
SL1 3WE Slough

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Berkshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Partners (4)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Gedeon Richter Plc.
Hungary
Net EU contribution
€ 0,00
Address
Gyomroi Str 19-21
H1103 Budapest

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Region
Közép-Magyarország Budapest Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITAET FUER BODENKULTUR WIEN
Austria
Net EU contribution
€ 0,00
Address
Gregor Mendel Strasse 33
1180 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH
Austria
Net EU contribution
€ 0,00
Address
Donaustrasse 99
3400 Klosterneuburg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Niederösterreich Wiener Umland/Nordteil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BIOMIN HOLDING GMBH
Austria
Net EU contribution
€ 0,00
Address
Erber Campus 1
3131 Getzersdorf Bei Traismauer

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Region
Niederösterreich Sankt Pölten
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00