Project description DEENESFRITPL Technological leap in recombinant protein production Recombinant proteins are widely used in industrial applications mainly in the form of enzymes and in the treatment of various diseases. Production of these proteins takes place in certain bacterial and yeast species. To address the limitations of these protein secretion platforms, the EU-funded Secreters project is working on novel systems that can generate challenging antibody structures. The work will provide important insight into protein export systems, while the technologies and methods used will fuel better and safer biopharmaceuticals and food production. A significant part of the project is dedicated to the training of the next generation of scientists in the field of protein engineering. Show the project objective Hide the project objective Objective The ‘SECRETERS’ partnership aims to bring about a step change in the production of recombinant proteins, particularly Biotherapeutics and Industrial Enzymes. Both are critical products for the EU biotechnology sector, with combined markets in excess of $140 billion p.a.; the former are essential for the treatment of major diseases whereas the latter permeate every aspect of our daily life. Many proteins in these categories pose severe problems in production, especially disulphide-bonded proteins and new format 'difficult-to-express' proteins. SECRETERS will train a team of 15 ESRs to develop a new generation of super-producing microbial production hosts, including Escherichia coli, Bacillus species and the yeast Pichia pastoris. The project capitalises on a series of recent innovations and involves close collaboration between 5 academic Beneficiaries, who provide world-leading expertise in redox chemistry, synthetic biology and protein expression, and 5 non-academic Beneficiaries, who include some of the world's premier biotherapeutic and industrial enzyme companies. It will enable the biotherapeutics industry to produce challenging medicines at lower costs, resulting in new drugs and wider patient access, and allow the enzymes industry to deliver a range of powerful new products. SECRETERS will equip ESRs with the interdisciplinary and intersectoral skills required to thrive in these industries, with quality assurance systems embedded throughout the programme and a commitment to a wide-ranging dissemination/outreach programme. Based on a responsible innovation approach, with clear foci on research and entrepreneurial training, SECRETERS will deliver a team of superbly-trained scientists, poised to engage in some of Europe's most important biotechnology sectors. Fields of science natural sciencesbiological sciencessynthetic biologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2018 - Innovative Training Networks Call for proposal H2020-MSCA-ITN-2018 See other projects for this call Funding Scheme MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN) Coordinator ACADEMISCH ZIEKENHUIS GRONINGEN Net EU contribution € 531 239,76 Address Hanzeplein 1 9713 GZ Groningen Netherlands See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITY OF KENT United Kingdom Net EU contribution € 606 345,12 Address The registry canterbury CT2 7NZ Canterbury, kent See on map Region South East (England) Kent East Kent Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 OULUN YLIOPISTO Finland Net EU contribution € 561 611,52 Address Pentti kaiteran katu 1 90014 Oulu See on map Region Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAET GREIFSWALD Germany Net EU contribution € 252 788,40 Address Domstrasse 11 17489 Greifswald See on map Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 HUMBOLDT-UNIVERSITAET ZU BERLIN Germany Net EU contribution € 252 788,40 Address Unter den linden 6 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ACIB GMBH Austria Net EU contribution € 528 414,48 Address Krenngasse 37/2 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 LONZA AG Switzerland Net EU contribution € 281 276,64 Address Muenchensteinerstrasse 38 4002 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AB ENZYMES GMBH Germany Net EU contribution € 252 788,40 Address Feldbergstrasse 78 64293 Darmstadt See on map Region Hessen Darmstadt Darmstadt, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UCB PHARMA SA Participation ended Belgium Net EU contribution € 0,00 Address Allee de la recherche 60 1070 Brussels / bruxelles See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BOEHRINGER INGELHEIM RCV GMBH & CO KG Austria Net EU contribution € 264 207,24 Address Dr boehringer gasse 5-11 1121 Wien See on map Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITATSMEDIZIN GREIFSWALD KORPERSCHAFT DES OFFENTLICHEN RECHTS Germany Net EU contribution € 252 788,40 Address Fleischmannstrasse 8 17489 Greifswald See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CELLTECH R&D LIMITED United Kingdom Net EU contribution € 303 172,56 Address 208 bath road SL1 3WE Slough See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Berkshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. Gedeon Richter Plc. Hungary Net EU contribution € 0,00 Address Gyomroi str 19-21 H1103 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSITAET FUER BODENKULTUR WIEN Austria Net EU contribution € 0,00 Address Gregor mendel strasse 33 1180 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH Austria Net EU contribution € 0,00 Address Donaustrasse 99 3400 Klosterneuburg See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ostösterreich Niederösterreich Wiener Umland/Nordteil Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. BIOMIN HOLDING GMBH Austria Net EU contribution € 0,00 Address Erber campus 1 3131 Getzersdorf bei traismauer See on map Region Ostösterreich Niederösterreich Sankt Pölten Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00