CORDIS - Forschungsergebnisse der EU
CORDIS

A new generation of microbial expression hosts and tools for the production of biotherapeutics and high-value enzymes

Projektbeschreibung

Technologiesprung in der rekombinanten Proteinproduktion

Rekombinante Proteine werden in der Industrie vor allem in Form von Enzymen und bei der Behandlung verschiedener Krankheiten eingesetzt. Die Produktion dieser Proteine erfolgt in bestimmten Bakterien- und Hefearten. Um die Grenzen dieser Proteinsekretions-Plattformen zu überwinden, arbeitet das EU-finanzierte Projekt Secreters an neuartigen Systemen, die anspruchsvolle Antikörperstrukturen erzeugen können. Die Arbeit wird wichtige Erkenntnisse über Proteinexportsysteme liefern, während die verwendeten Technologien und Methoden zu besseren und sichereren Biopharmazeutika und zur Nahrungsmittelproduktion beitragen werden. Ein wesentlicher Teil des Projekts ist der Ausbildung der nächsten Generation von Wissenschaftlerinnen und Wissenschaftlern auf dem Gebiet der Protein-Herstellung gewidmet.

Ziel

The ‘SECRETERS’ partnership aims to bring about a step change in the production of recombinant proteins, particularly Biotherapeutics and Industrial Enzymes. Both are critical products for the EU biotechnology sector, with combined markets in excess of $140 billion p.a.; the former are essential for the treatment of major diseases whereas the latter permeate every aspect of our daily life. Many proteins in these categories pose severe problems in production, especially disulphide-bonded proteins and new format 'difficult-to-express' proteins. SECRETERS will train a team of 15 ESRs to develop a new generation of super-producing microbial production hosts, including Escherichia coli, Bacillus species and the yeast Pichia pastoris. The project capitalises on a series of recent innovations and involves close collaboration between 5 academic Beneficiaries, who provide world-leading expertise in redox chemistry, synthetic biology and protein expression, and 5 non-academic Beneficiaries, who include some of the world's premier biotherapeutic and industrial enzyme companies. It will enable the biotherapeutics industry to produce challenging medicines at lower costs, resulting in new drugs and wider patient access, and allow the enzymes industry to deliver a range of powerful new products. SECRETERS will equip ESRs with the interdisciplinary and intersectoral skills required to thrive in these industries, with quality assurance systems embedded throughout the programme and a commitment to a wide-ranging dissemination/outreach programme. Based on a responsible innovation approach, with clear foci on research and entrepreneurial training, SECRETERS will deliver a team of superbly-trained scientists, poised to engage in some of Europe's most important biotechnology sectors.

Koordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Netto-EU-Beitrag
€ 531 239,76
Adresse
HANZEPLEIN 1
9713 GZ Groningen
Niederlande

Auf der Karte ansehen

Region
Noord-Nederland Groningen Overig Groningen
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 531 239,76

Beteiligte (11)

Partner (4)