Project description DEENESFRITPL The role of sugars in intestinal health The human microbiome plays a key role in health by protecting the host from invading pathogens, producing key nutrients and maintaining intestinal immunity. At the same time, microbiome imbalances can contribute to disease. The EU-funded SWEET CROSSTALK project is interested to delineate the complex interactions between microbiota and host at the molecular level. Particular emphasis will be given to milk sugars, which resemble the sugars found at the gut mucus layer and contribute to infant gut microbiota composition. The work will lead to the development of sugar-based therapeutics with a potential to improve human health. Show the project objective Hide the project objective Objective Sweet Crosstalk is a multidisciplinary European Training Network built to address the challenge of understanding, at a molecular level, how glycans are involved at the human mucosa–microbiota interface, and how this correlates with human well-being. Research into the human microbiome has reshaped the paradigm of our health and disease. In order to advance further, the time has arrived to understand it at a molecular level. Glycans dominate the microbiota-host interface and are thus ideally positioned to modulate these complex interactions.The research strategy of the Sweet Crosstalk programme focuses on optimal synergy between chemistry and biology. Smart chemistry drives the research to get a molecular-level grip on the role of these glycocodes and their interacting proteins, and advances in biology directs the research. The high quality and credibility of our consortium is ensured by a strong private-public partnership with complementary expertise ranging from chemical synthesis, biochemistry, structural biology to microbiology and cell biology. Our 7 academic groups are all renowned leaders in the glycoscience and microbiome fields, whereas the complementary 4 SMEs are specialized in glycan-based diagnostics and prophylactic therapies. This unique combination of scientific excellence and industry know-how covers the entire process from obtaining fundamental insight to the development of innovative early diagnostics and glycotherapeutics.Sweet Crosstalk also represents a unique research platform to train 15 outstanding Early Stage Researchers to be the new generation of innovative scientists with expert knowledge and skills in interdisciplinary glycoscience and human microbiome research. Our international, intersectoral and interdisciplinary training programme will equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the healthcare/biotech job market. Fields of science natural sciencesbiological sciencescell biologynatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesnatural sciencesbiological sciencesmicrobiologynatural sciencesbiological sciencesmolecular biologystructural biology Keywords Glycobiology Chemical Biology Microbiota Microbiome Mucin Structure-activity relationship Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2018 - Innovative Training Networks Call for proposal H2020-MSCA-ITN-2018 See other projects for this call Funding Scheme MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN) Coordinator UNIVERSITEIT UTRECHT Net EU contribution € 531 239,76 Address HEIDELBERGLAAN 8 3584 CS Utrecht Netherlands See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 531 239,76 Participants (10) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Italy Net EU contribution € 522 999,36 Address CORSO UMBERTO I, 40 80138 Napoli See on map Region Sud Campania Napoli Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 522 999,36 UNIVERSITEIT LEIDEN Netherlands Net EU contribution € 265 619,88 Address RAPENBURG 70 2311 EZ Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 265 619,88 HELSINGIN YLIOPISTO Finland Net EU contribution € 561 611,52 Address YLIOPISTONKATU 3 00014 Helsingin Yliopisto See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 561 611,52 UNIVERSITAT DE BARCELONA Spain Net EU contribution € 250 904,88 Address GRAN VIA DE LES CORTS CATALANES 585 08007 Barcelona See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 250 904,88 UNIVERSITE CATHOLIQUE DE LOUVAIN Belgium Net EU contribution € 256 320,00 Address PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve See on map Region Région wallonne Prov. Brabant Wallon Arr. Nivelles Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 256 320,00 QUADRAM INSTITUTE BIOSCIENCE United Kingdom Net EU contribution € 606 345,12 Address QUADRAM INSTITUTE BIOSCIENCE NORWICH RESEARCH PARK NR4 7UQ Norwich See on map Region East of England East Anglia Breckland and South Norfolk Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 606 345,12 INBIOSE Belgium Net EU contribution € 256 320,00 Address TECHNOLOGIEPARK 82 BUS 41 9052 Zwijnaarde See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 256 320,00 ICENI GLYCOSCIENCE LIMITED United Kingdom Net EU contribution € 303 172,56 Address B4 PARKSIDE KNOWLEDGE GATEWAY, NESFIELD ROAD CO4 3ZL COLCHESTER See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region East of England Essex Essex Haven Gateway Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 303 172,56 GLYCOM AS Denmark Net EU contribution € 297 522,00 Address KOGLE ALLE 4 2970 Horsholm See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Danmark Hovedstaden Nordsjælland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 297 522,00 NUTRILEADS BV Netherlands Net EU contribution € 265 619,88 Address BRONLAND 12 N 6708 WH Wageningen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Gelderland Veluwe Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 265 619,88 Partners (3) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. DANMARKS TEKNISKE UNIVERSITET Denmark Net EU contribution € 0,00 Address ANKER ENGELUNDS VEJ 101 2800 Kongens Lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSITEIT GENT Belgium Net EU contribution € 0,00 Address SINT PIETERSNIEUWSTRAAT 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSITY OF EAST ANGLIA United Kingdom Net EU contribution € 0,00 Address EARLHAM ROAD NR4 7TJ Norwich See on map Region East of England East Anglia Norwich and East Norfolk Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data